(56 nodes) Mixed, incl. Preribosome, large subunit precursor, and Ribosomal large subunit biogenesis network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PWP1	PWP1 homolog, endonuclein. (499 aa)
	NOP2	SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (822 aa)
	DDX24	DEAD-box helicase 24. (819 aa)
	GRWD1	Glutamate rich WD repeat containing 1. (445 aa)
	PUM3	Pumilio RNA binding family member 3. (648 aa)
	RRS1	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (365 aa)
	CEBPZ	CCAAT enhancer binding protein zeta. (1049 aa)
	SDAD1	Protein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. (687 aa)
	RBM19	RNA binding motif protein 19. (940 aa)
	PES1	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family. (597 aa)
	GNL3	G protein nucleolar 3. (551 aa)
	PPAN	Suppressor of SWI4 1 homolog isoform 1. (469 aa)
	NIFK	Nucleolar protein interacting with the FHA domain of MKI67. (294 aa)
	WDR12	Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (423 aa)
	ZNF622	Zinc finger protein 622. (473 aa)
	FTSJ3	pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. (836 aa)
	RRP1B	Ribosomal RNA processing 1B. (739 aa)
	EBNA1BP2	EBNA1 binding protein 2. (400 aa)
	DDX18	RNA helicase. (786 aa)
	RSL24D1	Ribosomal L24 domain containing 1. (163 aa)
	NOC2L	NOC2 like nucleolar associated transcriptional repressor. (713 aa)
	DDX27	DEAD-box helicase 27; Belongs to the DEAD box helicase family. (763 aa)
	GTPBP4	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (634 aa)
	NOC3L	Nucleolar complex protein 3 homolog. (799 aa)
	RPF1	Ribosome production factor 1 homolog. (349 aa)
	NOP53	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (470 aa)
	GNL3L	G protein nucleolar 3 like. (687 aa)
	RETREG1	Reticulophagy regulator 1. (565 aa)
	MRTO4	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (272 aa)
	PA2G4	Proliferation-associated 2G4. (372 aa)
	NLE1	Notchless homolog 1. (487 aa)
	A0A287ACW2_PIG	Peptidase_M24 domain-containing protein. (291 aa)
	ZNF593	C2H2-type domain-containing protein. (84 aa)
	GNL2	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (730 aa)
	DDX55	RNA helicase. (600 aa)
	RRP1	Ribosomal RNA processing protein 1 homolog A. (447 aa)
	WDR74	Uncharacterized protein. (388 aa)
	MAK16	Protein MAK16 homolog; Belongs to the MAK16 family. (297 aa)
	SURF6	Surfeit 6. (321 aa)
	DDX31	RNA helicase. (816 aa)
	DDX54	ATP-dependent RNA helicase DDX54; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (879 aa)
	LSG1	Large 60S subunit nuclear export GTPase 1. (651 aa)
	NSA2	Ribosome biogenesis protein NSA2 homolog isoform 1. (260 aa)
	RSL1D1	Ribosomal L1 domain-containing protein 1. (493 aa)
	A0A5G2QJF6_PIG	SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (105 aa)
	RRP12	Ribosomal RNA processing 12 homolog. (1256 aa)
	RBM28	RNA binding motif protein 28. (758 aa)
	NSUN6	NOP2/Sun RNA methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (598 aa)
	NIP7	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (192 aa)
	RPF2	Ribosome production factor 2 homolog. (306 aa)
	DDX56	Uncharacterized protein. (554 aa)
	EIF6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (246 aa)
	RPL7L1	60S ribosomal protein L7-like 1; Belongs to the universal ribosomal protein uL30 family. (340 aa)
	NMD3	60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. (525 aa)
	NOL12	Uncharacterized protein. (309 aa)
	RRP15	Ribosomal RNA processing 15 homolog. (303 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A287ACW2_PIG	A0A5G2QJF6_PIG	ENSSSCP00000041728	ENSSSCP00000062170	Peptidase_M24 domain-containing protein.	SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	0.519
A0A287ACW2_PIG	CEBPZ	ENSSSCP00000041728	ENSSSCP00000009059	Peptidase_M24 domain-containing protein.	CCAAT enhancer binding protein zeta.	0.632
A0A287ACW2_PIG	DDX18	ENSSSCP00000041728	ENSSSCP00000019922	Peptidase_M24 domain-containing protein.	RNA helicase.	0.827
A0A287ACW2_PIG	DDX24	ENSSSCP00000041728	ENSSSCP00000002673	Peptidase_M24 domain-containing protein.	DEAD-box helicase 24.	0.661
A0A287ACW2_PIG	DDX27	ENSSSCP00000041728	ENSSSCP00000023812	Peptidase_M24 domain-containing protein.	DEAD-box helicase 27; Belongs to the DEAD box helicase family.	0.570
A0A287ACW2_PIG	DDX31	ENSSSCP00000041728	ENSSSCP00000053770	Peptidase_M24 domain-containing protein.	RNA helicase.	0.696
A0A287ACW2_PIG	DDX54	ENSSSCP00000041728	ENSSSCP00000055689	Peptidase_M24 domain-containing protein.	ATP-dependent RNA helicase DDX54; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.	0.586
A0A287ACW2_PIG	DDX55	ENSSSCP00000041728	ENSSSCP00000045699	Peptidase_M24 domain-containing protein.	RNA helicase.	0.483
A0A287ACW2_PIG	DDX56	ENSSSCP00000041728	ENSSSCP00000070753	Peptidase_M24 domain-containing protein.	Uncharacterized protein.	0.798
A0A287ACW2_PIG	EBNA1BP2	ENSSSCP00000041728	ENSSSCP00000019639	Peptidase_M24 domain-containing protein.	EBNA1 binding protein 2.	0.651
A0A287ACW2_PIG	EIF6	ENSSSCP00000041728	ENSSSCP00000070860	Peptidase_M24 domain-containing protein.	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...]	0.860
A0A287ACW2_PIG	FTSJ3	ENSSSCP00000041728	ENSSSCP00000018316	Peptidase_M24 domain-containing protein.	pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.	0.810
A0A287ACW2_PIG	GNL2	ENSSSCP00000041728	ENSSSCP00000044599	Peptidase_M24 domain-containing protein.	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.	0.930
A0A287ACW2_PIG	GNL3	ENSSSCP00000041728	ENSSSCP00000012201	Peptidase_M24 domain-containing protein.	G protein nucleolar 3.	0.851
A0A287ACW2_PIG	GNL3L	ENSSSCP00000041728	ENSSSCP00000029757	Peptidase_M24 domain-containing protein.	G protein nucleolar 3 like.	0.851
A0A287ACW2_PIG	GRWD1	ENSSSCP00000041728	ENSSSCP00000003392	Peptidase_M24 domain-containing protein.	Glutamate rich WD repeat containing 1.	0.640
A0A287ACW2_PIG	GTPBP4	ENSSSCP00000041728	ENSSSCP00000024246	Peptidase_M24 domain-containing protein.	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.	0.954
A0A287ACW2_PIG	LSG1	ENSSSCP00000041728	ENSSSCP00000059075	Peptidase_M24 domain-containing protein.	Large 60S subunit nuclear export GTPase 1.	0.875
A0A287ACW2_PIG	MAK16	ENSSSCP00000041728	ENSSSCP00000047933	Peptidase_M24 domain-containing protein.	Protein MAK16 homolog; Belongs to the MAK16 family.	0.512
A0A287ACW2_PIG	MRTO4	ENSSSCP00000041728	ENSSSCP00000032410	Peptidase_M24 domain-containing protein.	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.	0.902