(18 nodes) Preribosome, large subunit precursor, and Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) network (Sus scrofa)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	RRS1	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (365 aa)
	PES1	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family. (597 aa)
	NIFK	Nucleolar protein interacting with the FHA domain of MKI67. (294 aa)
	WDR12	Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (423 aa)
	FTSJ3	pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. (836 aa)
	EBNA1BP2	EBNA1 binding protein 2. (400 aa)
	DDX18	RNA helicase. (786 aa)
	RSL24D1	Ribosomal L24 domain containing 1. (163 aa)
	NOC2L	NOC2 like nucleolar associated transcriptional repressor. (713 aa)
	GTPBP4	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (634 aa)
	RPF1	Ribosome production factor 1 homolog. (349 aa)
	MRTO4	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (272 aa)
	WDR74	Uncharacterized protein. (388 aa)
	MAK16	Protein MAK16 homolog; Belongs to the MAK16 family. (297 aa)
	NSA2	Ribosome biogenesis protein NSA2 homolog isoform 1. (260 aa)
	RSL1D1	Ribosomal L1 domain-containing protein 1. (493 aa)
	NIP7	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (192 aa)
	RPF2	Ribosome production factor 2 homolog. (306 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDX18	EBNA1BP2	ENSSSCP00000019922	ENSSSCP00000019639	RNA helicase.	EBNA1 binding protein 2.	0.971
DDX18	FTSJ3	ENSSSCP00000019922	ENSSSCP00000018316	RNA helicase.	pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.	0.988
DDX18	GTPBP4	ENSSSCP00000019922	ENSSSCP00000024246	RNA helicase.	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.	0.995
DDX18	MAK16	ENSSSCP00000019922	ENSSSCP00000047933	RNA helicase.	Protein MAK16 homolog; Belongs to the MAK16 family.	0.968
DDX18	MRTO4	ENSSSCP00000019922	ENSSSCP00000032410	RNA helicase.	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.	0.991
DDX18	NIFK	ENSSSCP00000019922	ENSSSCP00000016670	RNA helicase.	Nucleolar protein interacting with the FHA domain of MKI67.	0.995
DDX18	NIP7	ENSSSCP00000019922	ENSSSCP00000067928	RNA helicase.	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family.	0.989
DDX18	NOC2L	ENSSSCP00000019922	ENSSSCP00000023786	RNA helicase.	NOC2 like nucleolar associated transcriptional repressor.	0.994
DDX18	NSA2	ENSSSCP00000019922	ENSSSCP00000060892	RNA helicase.	Ribosome biogenesis protein NSA2 homolog isoform 1.	0.991
DDX18	PES1	ENSSSCP00000019922	ENSSSCP00000010681	RNA helicase.	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family.	0.995
DDX18	RPF1	ENSSSCP00000019922	ENSSSCP00000025516	RNA helicase.	Ribosome production factor 1 homolog.	0.987
DDX18	RPF2	ENSSSCP00000019922	ENSSSCP00000069681	RNA helicase.	Ribosome production factor 2 homolog.	0.984
DDX18	RRS1	ENSSSCP00000019922	ENSSSCP00000006625	RNA helicase.	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.	0.788
DDX18	RSL1D1	ENSSSCP00000019922	ENSSSCP00000061526	RNA helicase.	Ribosomal L1 domain-containing protein 1.	0.996
DDX18	RSL24D1	ENSSSCP00000019922	ENSSSCP00000021248	RNA helicase.	Ribosomal L24 domain containing 1.	0.965
DDX18	WDR12	ENSSSCP00000019922	ENSSSCP00000017075	RNA helicase.	Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.994
DDX18	WDR74	ENSSSCP00000019922	ENSSSCP00000046467	RNA helicase.	Uncharacterized protein.	0.993
EBNA1BP2	DDX18	ENSSSCP00000019639	ENSSSCP00000019922	EBNA1 binding protein 2.	RNA helicase.	0.971
EBNA1BP2	FTSJ3	ENSSSCP00000019639	ENSSSCP00000018316	EBNA1 binding protein 2.	pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.	0.994
EBNA1BP2	GTPBP4	ENSSSCP00000019639	ENSSSCP00000024246	EBNA1 binding protein 2.	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.	0.985