(59 nodes) Mixed, incl. Small GTPase, Ras-type, and Rap1 signalling network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RGL2	Uncharacterized protein. (802 aa)
	BCL2L12	BCL2 like 12. (255 aa)
	RRAS	RAS related. (218 aa)
	RASGRP1	RAS guanyl releasing protein 1. (797 aa)
	YWHAZ	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (260 aa)
	MOS	Proto-oncogene serine/threonine-protein kinase mos. (345 aa)
	RIT1	Ras like without CAAX 1. (219 aa)
	CCM2L	Cerebral cavernous malformations 2 protein-like isoform X1. (568 aa)
	SPRED2	Sprouty-related, EVH1 domain-containing protein 2 isoform a. (417 aa)
	KSR2	Kinase suppressor of ras 2. (950 aa)
	YWHAH	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
	OCEL1	Occludin/ELL domain containing 1. (258 aa)
	CTNNA1	Catenin alpha 1. (1090 aa)
	NF1	Neurofibromin 1. (2847 aa)
	KSR1	Kinase suppressor of ras 1. (928 aa)
	RAF1	RAF proto-oncogene serine/threonine-protein kinase isoform a. (668 aa)
	RASA4B	Uncharacterized protein. (882 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	RNF6	Ring finger protein 6. (663 aa)
	RASIP1	Ras interacting protein 1. (967 aa)
	MYBPH	Myosin-binding protein H. (511 aa)
	CTNNA2	Uncharacterized protein. (953 aa)
	MAP2K2	Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
	ARAF	Serine/threonine-protein kinase A-Raf; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade (By similarity). (609 aa)
	KRIT1	Uncharacterized protein. (814 aa)
	BRAP	BRCA1-associated protein. (592 aa)
	RAP1GAP2	RAP1 GTPase activating protein 2. (850 aa)
	RAP1GAP	RAP1 GTPase activating protein. (754 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (804 aa)
	RAP1B	RAP1B, member of RAS oncogene family. (184 aa)
	ARAP3	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X5. (1545 aa)
	RALBP1	RalA binding protein 1. (639 aa)
	RRAS2	Uncharacterized protein. (276 aa)
	RALB	RAS like proto-oncogene B. (206 aa)
	RALGAPA2	Ral GTPase activating protein catalytic alpha subunit 2. (1920 aa)
	SHOC2	Leucine-rich repeat protein SHOC-2 isoform X1. (582 aa)
	RASGRP2	Uncharacterized protein. (881 aa)
	NRAS	GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
	A0A287ARP2_PIG	Uncharacterized protein. (192 aa)
	PLCE1	Phosphoinositide phospholipase C. (2316 aa)
	SPRED3	Sprouty related EVH1 domain containing 3. (452 aa)
	CTNNA3	Catenin alpha 3. (895 aa)
	CDC25B	M-phase inducer phosphatase 2 isoform 1. (631 aa)
	RAP1A	RAP1A, member of RAS oncogene family. (184 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	DCDC2C	Uncharacterized protein. (738 aa)
	SIPA1L3	SPAR_C domain-containing protein. (718 aa)
	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	YWHAB	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (264 aa)
	YWHAG	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
	RALA	Ras-related protein Ral-A isoform X1. (206 aa)
	RGL1	Ral guanine nucleotide dissociation stimulator-like 1 isoform 3. (875 aa)
	A0A5G2QE41_PIG	Uncharacterized protein. (599 aa)
	SIPA1	Signal-induced proliferation-associated 1. (1139 aa)
	YWHAQ	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family. (246 aa)
	SPRED1	Sprouty related EVH1 domain containing 1. (445 aa)
	RGL3	Ral guanine nucleotide dissociation stimulator like 3. (711 aa)
	RASA2	RAS p21 protein activator 2. (854 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (568 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A287ARP2_PIG	ARAF	ENSSSCP00000046576	ENSSSCP00000030304	Uncharacterized protein.	Serine/threonine-protein kinase A-Raf; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade (By similarity).	0.437
A0A287ARP2_PIG	NF1	ENSSSCP00000046576	ENSSSCP00000018804	Uncharacterized protein.	Neurofibromin 1.	0.469
A0A287ARP2_PIG	RASGRP1	ENSSSCP00000046576	ENSSSCP00000005160	Uncharacterized protein.	RAS guanyl releasing protein 1.	0.617
A0A5G2QE41_PIG	SIPA1L3	ENSSSCP00000062428	ENSSSCP00000056315	Uncharacterized protein.	SPAR_C domain-containing protein.	0.900
ARAF	A0A287ARP2_PIG	ENSSSCP00000030304	ENSSSCP00000046576	Serine/threonine-protein kinase A-Raf; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade (By similarity).	Uncharacterized protein.	0.437
ARAF	BRAF	ENSSSCP00000030304	ENSSSCP00000035615	Serine/threonine-protein kinase A-Raf; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade (By similarity).	B-Raf proto-oncogene, serine/threonine kinase.	0.704
ARAF	HRAS	ENSSSCP00000030304	ENSSSCP00000051149	Serine/threonine-protein kinase A-Raf; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade (By similarity).	HRas proto-oncogene, GTPase.	0.968
ARAF	KRAS	ENSSSCP00000030304	ENSSSCP00000021836	Serine/threonine-protein kinase A-Raf; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade (By similarity).	KRAS proto-oncogene, GTPase.	0.733
ARAF	KSR1	ENSSSCP00000030304	ENSSSCP00000018809	Serine/threonine-protein kinase A-Raf; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade (By similarity).	Kinase suppressor of ras 1.	0.472
ARAF	KSR2	ENSSSCP00000030304	ENSSSCP00000010519	Serine/threonine-protein kinase A-Raf; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade (By similarity).	Kinase suppressor of ras 2.	0.411
ARAF	MAP2K1	ENSSSCP00000030304	ENSSSCP00000056482	Serine/threonine-protein kinase A-Raf; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade (By similarity).	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.	0.965
ARAF	MAP2K2	ENSSSCP00000030304	ENSSSCP00000029885	Serine/threonine-protein kinase A-Raf; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade (By similarity).	Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily.	0.973
ARAF	MAPK1	ENSSSCP00000030304	ENSSSCP00000073842	Serine/threonine-protein kinase A-Raf; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade (By similarity).	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.401
ARAF	MOS	ENSSSCP00000030304	ENSSSCP00000006661	Serine/threonine-protein kinase A-Raf; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade (By similarity).	Proto-oncogene serine/threonine-protein kinase mos.	0.900
ARAF	NRAS	ENSSSCP00000030304	ENSSSCP00000046185	Serine/threonine-protein kinase A-Raf; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade (By similarity).	GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family.	0.978
ARAF	RAF1	ENSSSCP00000030304	ENSSSCP00000021146	Serine/threonine-protein kinase A-Raf; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade (By similarity).	RAF proto-oncogene serine/threonine-protein kinase isoform a.	0.902
ARAF	RALA	ENSSSCP00000030304	ENSSSCP00000061817	Serine/threonine-protein kinase A-Raf; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade (By similarity).	Ras-related protein Ral-A isoform X1.	0.531
ARAF	RALB	ENSSSCP00000030304	ENSSSCP00000038583	Serine/threonine-protein kinase A-Raf; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade (By similarity).	RAS like proto-oncogene B.	0.531
ARAF	RALGAPA2	ENSSSCP00000030304	ENSSSCP00000039034	Serine/threonine-protein kinase A-Raf; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade (By similarity).	Ral GTPase activating protein catalytic alpha subunit 2.	0.431
ARAF	RAP1A	ENSSSCP00000030304	ENSSSCP00000050852	Serine/threonine-protein kinase A-Raf; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade (By similarity).	RAP1A, member of RAS oncogene family.	0.954