STRINGSTRING
ARHGAP9 ARHGAP9 CAP2 CAP2 WHAMM WHAMM IQGAP1 IQGAP1 CFL2 CFL2 AKAP13 AKAP13 ELMO3 ELMO3 ARHGAP35 ARHGAP35 CAP1 CAP1 RHOV RHOV PAK6 PAK6 OSTF1 OSTF1 ARPC5L ARPC5L TAGLN2 TAGLN2 IQGAP3 IQGAP3 RHOC RHOC ARPC1A ARPC1A PFN4 PFN4 F1S145_PIG F1S145_PIG WASF3 WASF3 DIAPH3 DIAPH3 DOCK5 DOCK5 ARPC3 ARPC3 SSH1 SSH1 ABI1 ABI1 NCKIPSD NCKIPSD TWF2 TWF2 BRK1 BRK1 PAK2 PAK2 TIAM1 TIAM1 DOCK11 DOCK11 RASAL3 RASAL3 MYO9B MYO9B ARPC5 ARPC5 ACTR3 ACTR3 DOCK10 DOCK10 ZYX ZYX DBNL DBNL DOCK2 DOCK2 WIPF2 WIPF2 GIT1 GIT1 PFN1 PFN1 PLEKHG3 PLEKHG3 PFN2 PFN2 SCRN3 SCRN3 ARHGAP5 ARHGAP5 ARHGEF38 ARHGEF38 WASF2 WASF2 RHOD RHOD NCK1 NCK1 F1RSX1_PIG F1RSX1_PIG RHOJ RHOJ FMNL3 FMNL3 ELMO2 ELMO2 IQGAP2 IQGAP2 CFL1 CFL1 CDC42 CDC42 PAK1 PAK1 TAGLN3 TAGLN3 MCF2 MCF2 ARPC1B ARPC1B ARHGEF7 ARHGEF7 SSH2 SSH2 WDR1 WDR1 ACTB ACTB APBB1IP APBB1IP DOCK8 DOCK8 ARPC4 ARPC4 ACTR2 ACTR2 ARPC2 ARPC2 ABI2 ABI2 DOCK1 DOCK1 GIT2 GIT2 RHOH RHOH GSN GSN ACTN4 ACTN4 GNA13 GNA13 ACTG1 ACTG1 LOC110256054 LOC110256054 ENAH ENAH NCK2 NCK2 WIPF1 WIPF1 ARHGEF6 ARHGEF6 TBX1 TBX1 NCKAP1 NCKAP1 ARHGEF1 ARHGEF1 ARHGEF16 ARHGEF16 RHOA RHOA WASF1 WASF1 ARHGDIA ARHGDIA VASP VASP RAC3 RAC3 ARHGEF12 ARHGEF12 CYFIP2 CYFIP2 FMNL1 FMNL1 A0A287AXW5_PIG A0A287AXW5_PIG ARHGDIB ARHGDIB WAS WAS EVL EVL RND3 RND3 RHOG RHOG NET1 NET1 CORO1B CORO1B LIMK2 LIMK2 DBN1 DBN1 BAIAP2 BAIAP2 PAK3 PAK3 ACTRT3 ACTRT3 ARHGDIG ARHGDIG A0A287BRC5_PIG A0A287BRC5_PIG RASA1 RASA1 SWAP70 SWAP70 ACTL10 ACTL10 WASL WASL A0A5G2QCH0_PIG A0A5G2QCH0_PIG RAC1 RAC1 DIAPH2 DIAPH2 ACTR3B ACTR3B FUNDC2 FUNDC2 A0A5G2QL47_PIG A0A5G2QL47_PIG WIPF3 WIPF3 NCKAP1L NCKAP1L MCAM MCAM PAK4 PAK4 ARHGEF11 ARHGEF11 PAK5 PAK5 RHOB RHOB RAC2 RAC2 HCLS1 HCLS1 FMNL2 FMNL2 LIMK1 LIMK1 DSTN DSTN LOC102158424 LOC102158424
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARHGAP9Rho GTPase activating protein 9. (808 aa)
CAP2Adenylyl cyclase-associated protein; Belongs to the CAP family. (486 aa)
WHAMMWASP homolog associated with actin, golgi membranes and microtubules. (809 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1709 aa)
CFL2Cofilin-2; Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity). (166 aa)
AKAP13Uncharacterized protein. (1420 aa)
ELMO3Engulfment and cell motility 3. (719 aa)
ARHGAP35Rho GTPase-activating protein 35. (1500 aa)
CAP1Adenylyl cyclase-associated protein; Belongs to the CAP family. (473 aa)
RHOVUncharacterized protein. (236 aa)
PAK6Non-specific serine/threonine protein kinase. (709 aa)
OSTF1Osteoclast-stimulating factor 1; Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity. (234 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (303 aa)
TAGLN2Transgelin; Belongs to the calponin family. (213 aa)
IQGAP3IQ motif containing GTPase activating protein 3. (1696 aa)
RHOCRas homolog family member C. (202 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
PFN4Profilin; Belongs to the profilin family. (129 aa)
F1S145_PIGUncharacterized protein; Belongs to the calmodulin family. (196 aa)
WASF3Wiskott-Aldrich syndrome protein family member 3 isoform X1. (498 aa)
DIAPH3Diaphanous related formin 3. (1138 aa)
DOCK5Dedicator of cytokinesis 5; Belongs to the DOCK family. (1867 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
SSH1Slingshot protein phosphatase 1. (992 aa)
ABI1Abl interactor 1 isoform b. (481 aa)
NCKIPSDNCK interacting protein with SH3 domain. (715 aa)
TWF2Twinfilin actin binding protein 2. (500 aa)
BRK1BRICK1 subunit of SCAR/WAVE actin nucleating complex. (103 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1611 aa)
DOCK11Dedicator of cytokinesis 11; Belongs to the DOCK family. (2056 aa)
RASAL3RAS protein activator like 3. (1012 aa)
MYO9BMyosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2194 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (422 aa)
DOCK10Dedicator of cytokinesis 10; Belongs to the DOCK family. (2201 aa)
ZYXZyxin. (588 aa)
DBNLDrebrin like. (429 aa)
DOCK2Dedicator of cytokinesis protein 2; Belongs to the DOCK family. (1827 aa)
WIPF2WAS/WASL-interacting protein family member 2. (440 aa)
GIT1GIT ArfGAP 1. (761 aa)
PFN1Profilin; Belongs to the profilin family. (212 aa)
PLEKHG3Pleckstrin homology and RhoGEF domain containing G3. (1359 aa)
PFN2Profilin; Belongs to the profilin family. (189 aa)
SCRN3Secernin 3. (430 aa)
ARHGAP5Rho GTPase-activating protein 5 isoform X1. (1503 aa)
ARHGEF38Rho guanine nucleotide exchange factor 38. (778 aa)
WASF2Wiskott-Aldrich syndrome protein family member 2 isoform 2. (498 aa)
RHODRas homolog family member D. (203 aa)
NCK1Cytoplasmic protein. (377 aa)
F1RSX1_PIGUncharacterized protein. (200 aa)
RHOJUncharacterized protein. (213 aa)
FMNL3Formin-like protein 3 isoform X4. (1027 aa)
ELMO2Engulfment and cell motility 2. (732 aa)
IQGAP2IQ motif containing GTPase activating protein 2. (1542 aa)
CFL1Cofilin-1; Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up- regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Required for neural tube morphogenesis and neural crest cell migration (By similarity). (179 aa)
CDC42Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (197 aa)
PAK1Non-specific serine/threonine protein kinase. (546 aa)
TAGLN3Transgelin-3. (217 aa)
MCF2MCF.2 cell line derived transforming sequence. (1172 aa)
ARPC1BActin related protein 2/3 complex subunit 1B. (440 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (862 aa)
SSH2Uncharacterized protein. (145 aa)
WDR1WD repeat-containing protein 1 isoform 1. (606 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
APBB1IPAmyloid beta precursor protein binding family B member 1 interacting protein. (688 aa)
DOCK8Dedicator of cytokinesis 8; Belongs to the DOCK family. (1998 aa)
ARPC4Actin related protein 2/3 complex subunit 4. (231 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (404 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (273 aa)
ABI2Abl interactor 2. (542 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1828 aa)
GIT2GIT ArfGAP 2. (853 aa)
RHOHRho-related GTP-binding protein RhoH. (191 aa)
GSNGelsolin; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis (By similarity). Belongs to the villin/gelsolin family. (780 aa)
ACTN4Actinin alpha 4. (1160 aa)
GNA13G protein subunit alpha 13. (377 aa)
ACTG1Actin gamma 1. (381 aa)
LOC110256054WH2 domain-containing protein. (558 aa)
ENAHENAH actin regulator. (782 aa)
NCK2Cytoplasmic protein. (376 aa)
WIPF1WH2 domain-containing protein. (515 aa)
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor 6. (773 aa)
TBX1T-box transcription factor 1. (490 aa)
NCKAP1NCK associated protein 1. (1134 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (1181 aa)
ARHGEF16Rho guanine nucleotide exchange factor 16. (766 aa)
RHOATransforming protein RhoA isoform 1. (193 aa)
WASF1WH2 domain-containing protein. (559 aa)
ARHGDIARho GDP dissociation inhibitor alpha. (270 aa)
VASPVasodilator stimulated phosphoprotein. (389 aa)
RAC3Rac family small GTPase 3. (192 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1544 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
FMNL1Formin like 1. (1175 aa)
A0A287AXW5_PIGProfilin; Belongs to the profilin family. (129 aa)
ARHGDIBUncharacterized protein. (200 aa)
WASWASP actin nucleation promoting factor. (500 aa)
EVLEnah/Vasp-like. (466 aa)
RND3Rho-related GTP-binding protein RhoE; Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. (244 aa)
RHOGUncharacterized protein. (394 aa)
NET1Neuroepithelial cell transforming 1. (574 aa)
CORO1BCoronin; Belongs to the WD repeat coronin family. (496 aa)
LIMK2LIM domain kinase 2. (793 aa)
DBN1Drebrin 1. (857 aa)
BAIAP2BAI1 associated protein 2. (575 aa)
PAK3Non-specific serine/threonine protein kinase. (592 aa)
ACTRT3Actin-related protein T3; Belongs to the actin family. (372 aa)
ARHGDIGRho GDP dissociation inhibitor gamma. (267 aa)
A0A287BRC5_PIGADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (190 aa)
RASA1RAS p21 protein activator 1. (1040 aa)
SWAP70Switching B cell complex subunit SWAP70. (585 aa)
ACTL10Actin like 10; Belongs to the actin family. (245 aa)
WASLWASP like actin nucleation promoting factor. (511 aa)
A0A5G2QCH0_PIGUncharacterized protein. (309 aa)
RAC1Rac family small GTPase 1. (186 aa)
DIAPH2Diaphanous related formin 2. (1100 aa)
ACTR3BUncharacterized protein; Belongs to the actin family. (463 aa)
FUNDC2FUN14 domain-containing protein 2; Belongs to the FUN14 family. (215 aa)
A0A5G2QL47_PIGUncharacterized protein. (116 aa)
WIPF3WAS/WASL interacting protein family member 3. (489 aa)
NCKAP1LNCK associated protein 1 like. (1128 aa)
MCAMMelanoma cell adhesion molecule. (667 aa)
PAK4Non-specific serine/threonine protein kinase. (591 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11. (1577 aa)
PAK5Non-specific serine/threonine protein kinase. (744 aa)
RHOBRho-related GTP-binding protein RhoB. (196 aa)
RAC2Rac family small GTPase 2. (217 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (525 aa)
FMNL2Formin like 2. (1092 aa)
LIMK1LIM domain kinase 1. (681 aa)
DSTNDestrin; Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner. (169 aa)
LOC102158424Uncharacterized protein; Belongs to the actin family. (466 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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