(66 nodes) Small GTPase Rho, and CDC42 GTPase cycle network (Sus scrofa)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IQGAP1	IQ motif containing GTPase activating protein 1. (1709 aa)
	CFL2	Cofilin-2; Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity). (166 aa)
	AKAP13	Uncharacterized protein. (1420 aa)
	ELMO3	Engulfment and cell motility 3. (719 aa)
	ARHGAP35	Rho GTPase-activating protein 35. (1500 aa)
	RHOV	Uncharacterized protein. (236 aa)
	PAK6	Non-specific serine/threonine protein kinase. (709 aa)
	IQGAP3	IQ motif containing GTPase activating protein 3. (1696 aa)
	F1S145_PIG	Uncharacterized protein; Belongs to the calmodulin family. (196 aa)
	DIAPH3	Diaphanous related formin 3. (1138 aa)
	DOCK5	Dedicator of cytokinesis 5; Belongs to the DOCK family. (1867 aa)
	SSH1	Slingshot protein phosphatase 1. (992 aa)
	PAK2	Non-specific serine/threonine protein kinase. (524 aa)
	TIAM1	T cell lymphoma invasion and metastasis 1. (1611 aa)
	DOCK11	Dedicator of cytokinesis 11; Belongs to the DOCK family. (2056 aa)
	RASAL3	RAS protein activator like 3. (1012 aa)
	MYO9B	Myosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2194 aa)
	DOCK10	Dedicator of cytokinesis 10; Belongs to the DOCK family. (2201 aa)
	DOCK2	Dedicator of cytokinesis protein 2; Belongs to the DOCK family. (1827 aa)
	GIT1	GIT ArfGAP 1. (761 aa)
	PLEKHG3	Pleckstrin homology and RhoGEF domain containing G3. (1359 aa)
	ARHGAP5	Rho GTPase-activating protein 5 isoform X1. (1503 aa)
	RHOD	Ras homolog family member D. (203 aa)
	NCK1	Cytoplasmic protein. (377 aa)
	F1RSX1_PIG	Uncharacterized protein. (200 aa)
	RHOJ	Uncharacterized protein. (213 aa)
	FMNL3	Formin-like protein 3 isoform X4. (1027 aa)
	ELMO2	Engulfment and cell motility 2. (732 aa)
	IQGAP2	IQ motif containing GTPase activating protein 2. (1542 aa)
	CFL1	Cofilin-1; Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up- regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Required for neural tube morphogenesis and neural crest cell migration (By similarity). (179 aa)
	CDC42	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (197 aa)
	PAK1	Non-specific serine/threonine protein kinase. (546 aa)
	MCF2	MCF.2 cell line derived transforming sequence. (1172 aa)
	ARHGEF7	Rho guanine nucleotide exchange factor 7. (862 aa)
	SSH2	Uncharacterized protein. (145 aa)
	DOCK8	Dedicator of cytokinesis 8; Belongs to the DOCK family. (1998 aa)
	DOCK1	Dedicator of cytokinesis 1; Belongs to the DOCK family. (1828 aa)
	GIT2	GIT ArfGAP 2. (853 aa)
	RHOH	Rho-related GTP-binding protein RhoH. (191 aa)
	GNA13	G protein subunit alpha 13. (377 aa)
	NCK2	Cytoplasmic protein. (376 aa)
	ARHGEF6	Rac/Cdc42 guanine nucleotide exchange factor 6. (773 aa)
	ARHGEF1	Rho guanine nucleotide exchange factor 1. (1181 aa)
	ARHGEF16	Rho guanine nucleotide exchange factor 16. (766 aa)
	RHOA	Transforming protein RhoA isoform 1. (193 aa)
	ARHGDIA	Rho GDP dissociation inhibitor alpha. (270 aa)
	RAC3	Rac family small GTPase 3. (192 aa)
	ARHGEF12	Rho guanine nucleotide exchange factor 12. (1544 aa)
	FMNL1	Formin like 1. (1175 aa)
	ARHGDIB	Uncharacterized protein. (200 aa)
	RND3	Rho-related GTP-binding protein RhoE; Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. (244 aa)
	RHOG	Uncharacterized protein. (394 aa)
	LIMK2	LIM domain kinase 2. (793 aa)
	PAK3	Non-specific serine/threonine protein kinase. (592 aa)
	ARHGDIG	Rho GDP dissociation inhibitor gamma. (267 aa)
	RASA1	RAS p21 protein activator 1. (1040 aa)
	SWAP70	Switching B cell complex subunit SWAP70. (585 aa)
	RAC1	Rac family small GTPase 1. (186 aa)
	DIAPH2	Diaphanous related formin 2. (1100 aa)
	MCAM	Melanoma cell adhesion molecule. (667 aa)
	PAK4	Non-specific serine/threonine protein kinase. (591 aa)
	ARHGEF11	Rho guanine nucleotide exchange factor 11. (1577 aa)
	PAK5	Non-specific serine/threonine protein kinase. (744 aa)
	RHOB	Rho-related GTP-binding protein RhoB. (196 aa)
	RAC2	Rac family small GTPase 2. (217 aa)
	LIMK1	LIM domain kinase 1. (681 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKAP13	ARHGEF1	ENSSSCP00000002454	ENSSSCP00000044252	Uncharacterized protein.	Rho guanine nucleotide exchange factor 1.	0.449
AKAP13	ARHGEF11	ENSSSCP00000002454	ENSSSCP00000068410	Uncharacterized protein.	Rho guanine nucleotide exchange factor 11.	0.908
AKAP13	ARHGEF12	ENSSSCP00000002454	ENSSSCP00000047751	Uncharacterized protein.	Rho guanine nucleotide exchange factor 12.	0.915
AKAP13	ARHGEF16	ENSSSCP00000002454	ENSSSCP00000045630	Uncharacterized protein.	Rho guanine nucleotide exchange factor 16.	0.527
AKAP13	FMNL3	ENSSSCP00000002454	ENSSSCP00000026968	Uncharacterized protein.	Formin-like protein 3 isoform X4.	0.580
AKAP13	GNA13	ENSSSCP00000002454	ENSSSCP00000040165	Uncharacterized protein.	G protein subunit alpha 13.	0.927
AKAP13	IQGAP2	ENSSSCP00000002454	ENSSSCP00000028043	Uncharacterized protein.	IQ motif containing GTPase activating protein 2.	0.518
AKAP13	MYO9B	ENSSSCP00000002454	ENSSSCP00000014753	Uncharacterized protein.	Myosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.541
AKAP13	RAC1	ENSSSCP00000002454	ENSSSCP00000062132	Uncharacterized protein.	Rac family small GTPase 1.	0.587
AKAP13	RHOA	ENSSSCP00000002454	ENSSSCP00000045785	Uncharacterized protein.	Transforming protein RhoA isoform 1.	0.946
AKAP13	RHOB	ENSSSCP00000002454	ENSSSCP00000069510	Uncharacterized protein.	Rho-related GTP-binding protein RhoB.	0.743
AKAP13	RND3	ENSSSCP00000002454	ENSSSCP00000051155	Uncharacterized protein.	Rho-related GTP-binding protein RhoE; Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.	0.426
ARHGAP35	ARHGAP5	ENSSSCP00000003363	ENSSSCP00000021934	Rho GTPase-activating protein 35.	Rho GTPase-activating protein 5 isoform X1.	0.900
ARHGAP35	CDC42	ENSSSCP00000003363	ENSSSCP00000029815	Rho GTPase-activating protein 35.	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	0.596
ARHGAP35	IQGAP2	ENSSSCP00000003363	ENSSSCP00000028043	Rho GTPase-activating protein 35.	IQ motif containing GTPase activating protein 2.	0.434
ARHGAP35	RAC1	ENSSSCP00000003363	ENSSSCP00000062132	Rho GTPase-activating protein 35.	Rac family small GTPase 1.	0.515
ARHGAP35	RAC2	ENSSSCP00000003363	ENSSSCP00000070230	Rho GTPase-activating protein 35.	Rac family small GTPase 2.	0.541
ARHGAP35	RAC3	ENSSSCP00000003363	ENSSSCP00000047362	Rho GTPase-activating protein 35.	Rac family small GTPase 3.	0.541
ARHGAP35	RASA1	ENSSSCP00000003363	ENSSSCP00000060406	Rho GTPase-activating protein 35.	RAS p21 protein activator 1.	0.990
ARHGAP35	RHOA	ENSSSCP00000003363	ENSSSCP00000045785	Rho GTPase-activating protein 35.	Transforming protein RhoA isoform 1.	0.962