57 items (Sus scrofa) - STRING interaction network

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	DCN	Decorin; May affect the rate of fibrils formation. (359 aa)
	LUM	Lumican. (341 aa)
	LOXL1	Lysyl oxidase like 1. (591 aa)
	FBLN5	Fibulin-5 isoform X2. (461 aa)
	COL10A1	Type X collagen. (675 aa)
	FBN1	Fibrillin-1; [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus [...] (2871 aa)
	ADAMTS4	ADAM metallopeptidase with thrombospondin type 1 motif 4. (872 aa)
	BCAN	Brevican core protein isoform X1. (906 aa)
	ASPN	Asporin. (370 aa)
	OMD	Osteomodulin. (422 aa)
	MATN3	Matrilin 3. (487 aa)
	SPP1	Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. (303 aa)
	POSTN	Periostin. (836 aa)
	BMP1	Metalloendopeptidase. (987 aa)
	LOXL4	Lysyl oxidase like 4. (757 aa)
	FBLN2	Fibulin-2 isoform a. (1221 aa)
	ADAMTS5	ADAM metallopeptidase with thrombospondin type 1 motif 5. (929 aa)
	TIMP1	Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity). (207 aa)
	TNMD	Tenomodulin. (317 aa)
	CD44	CD44 molecule (Indian blood group). (767 aa)
	COMP	Cartilage oligomeric matrix protein. (756 aa)
	CILP2	Cartilage intermediate layer protein 2. (1163 aa)
	HAPLN1	Hyaluronan and proteoglycan link protein 1; Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix; Belongs to the HAPLN family. (354 aa)
	LOX	Protein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity); Belongs to the lysyl oxidase family. (419 aa)
	MMP7	ZnMc domain-containing protein. (267 aa)
	MMP1	Stromelysin-1 preproprotein. (477 aa)
	MMP12	Macrophage metalloelastase preproprotein. (476 aa)
	MMP13	Matrix metallopeptidase 13. (470 aa)
	FMOD	Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity). (376 aa)
	SOX9	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
	MMP14	Matrix metalloproteinase-14; Endopeptidase that degrades various components of the extracellular matrix, such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which i [...] (606 aa)
	FBN3	Fibrillin 3. (2858 aa)
	MKX	Mohawk homeobox. (351 aa)
	BGN	Biglycan; May be involved in collagen fiber assembly. (338 aa)
	DPT	Dermatopontin; Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation (By similarity). Accelerates collagen fibril formation, and stabilizes collagen fibrils against low- temperature dissociation. (201 aa)
	TIMP3	TIMP metallopeptidase inhibitor 3. (211 aa)
	CCN2	CCN family member 2; Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation- dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity). (354 aa)
	ADAMTS17	ADAM metallopeptidase with thrombospondin type 1 motif 17. (1273 aa)
	SVEP1	Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1. (3532 aa)
	OGN	Osteoglycin/mimecan. (298 aa)
	LOXL2	Lysyl oxidase like 2. (758 aa)
	ELN	Elastin. (674 aa)
	MMP9	Matrix metalloproteinase-9. (708 aa)
	MFAP4	Microfibril associated protein 4. (304 aa)
	SCX	Basic helix-loop-helix transcription factor scleraxis. (310 aa)
	PRELP	Proline and arginine rich end leucine rich repeat protein. (381 aa)
	ACAN	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. (2434 aa)
	EMILIN1	Elastin microfibril interfacer 1. (1292 aa)
	TGM2	Transglutaminase 2. (696 aa)
	FBN2	Fibrillin 2. (2910 aa)
	MFAP2	Microfibril associated protein 2. (276 aa)
	TIMP2	Uncharacterized protein. (257 aa)
	LOXL3	Lysyl oxidase like 3. (814 aa)
	RUNX2	Runt-related transcription factor 2 isoform a. (625 aa)
	MFAP5	Microfibril associated protein 5. (236 aa)
	LTBP2	Latent transforming growth factor beta binding protein 2. (1814 aa)
	MMP2	Uncharacterized protein. (610 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAN	ADAMTS4	ENSSSCP00000052661	ENSSSCP00000006778	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	ADAM metallopeptidase with thrombospondin type 1 motif 4.	0.915
ACAN	ADAMTS5	ENSSSCP00000052661	ENSSSCP00000012809	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	ADAM metallopeptidase with thrombospondin type 1 motif 5.	0.890
ACAN	ASPN	ENSSSCP00000052661	ENSSSCP00000008621	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Asporin.	0.538
ACAN	BCAN	ENSSSCP00000052661	ENSSSCP00000006902	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Brevican core protein isoform X1.	0.578
ACAN	BGN	ENSSSCP00000052661	ENSSSCP00000029666	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Biglycan; May be involved in collagen fiber assembly.	0.899
ACAN	CCN2	ENSSSCP00000052661	ENSSSCP00000037172	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	CCN family member 2; Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation- dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity).	0.549
ACAN	CD44	ENSSSCP00000052661	ENSSSCP00000014130	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	CD44 molecule (Indian blood group).	0.682
ACAN	COL10A1	ENSSSCP00000052661	ENSSSCP00000004785	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Type X collagen.	0.891
ACAN	COMP	ENSSSCP00000052661	ENSSSCP00000014796	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Cartilage oligomeric matrix protein.	0.945
ACAN	DCN	ENSSSCP00000052661	ENSSSCP00000000977	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Decorin; May affect the rate of fibrils formation.	0.926
ACAN	ELN	ENSSSCP00000052661	ENSSSCP00000048714	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Elastin.	0.719
ACAN	FBLN2	ENSSSCP00000052661	ENSSSCP00000012373	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Fibulin-2 isoform a.	0.551
ACAN	FBN1	ENSSSCP00000052661	ENSSSCP00000005017	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Fibrillin-1; [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus [...]	0.455
ACAN	FMOD	ENSSSCP00000052661	ENSSSCP00000016193	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity).	0.918
ACAN	HAPLN1	ENSSSCP00000052661	ENSSSCP00000015032	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Hyaluronan and proteoglycan link protein 1; Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix; Belongs to the HAPLN family.	0.972
ACAN	LUM	ENSSSCP00000052661	ENSSSCP00000000978	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Lumican.	0.824
ACAN	MATN3	ENSSSCP00000052661	ENSSSCP00000009174	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Matrilin 3.	0.733
ACAN	MKX	ENSSSCP00000052661	ENSSSCP00000027729	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Mohawk homeobox.	0.436
ACAN	MMP1	ENSSSCP00000052661	ENSSSCP00000015910	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Stromelysin-1 preproprotein.	0.879
ACAN	MMP12	ENSSSCP00000052661	ENSSSCP00000015911	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Macrophage metalloelastase preproprotein.	0.591