STRINGSTRING
COL10A1 COL10A1 SPP1 SPP1 ADAMTS5 ADAMTS5 TIMP1 TIMP1 CD44 CD44 MMP7 MMP7 MMP1 MMP1 MMP13 MMP13 SOX9 SOX9 MMP14 MMP14 TIMP3 TIMP3 MMP9 MMP9 TIMP2 TIMP2 RUNX2 RUNX2 MMP2 MMP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
COL10A1Type X collagen. (675 aa)
SPP1Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. (303 aa)
ADAMTS5ADAM metallopeptidase with thrombospondin type 1 motif 5. (929 aa)
TIMP1Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity). (207 aa)
CD44CD44 molecule (Indian blood group). (767 aa)
MMP7ZnMc domain-containing protein. (267 aa)
MMP1Stromelysin-1 preproprotein. (477 aa)
MMP13Matrix metallopeptidase 13. (470 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
MMP14Matrix metalloproteinase-14; Endopeptidase that degrades various components of the extracellular matrix, such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which i [...] (606 aa)
TIMP3TIMP metallopeptidase inhibitor 3. (211 aa)
MMP9Matrix metalloproteinase-9. (708 aa)
TIMP2Uncharacterized protein. (257 aa)
RUNX2Runt-related transcription factor 2 isoform a. (625 aa)
MMP2Uncharacterized protein. (610 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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