Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CISH | EPOR | ENSSSCP00000012168 | ENSSSCP00000014472 | Cytokine-inducible SH2-containing protein isoform 2. | Erythropoietin receptor; Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate LYN tyrosine kinase (By similarity). | 0.634 |
| CISH | IL4R | ENSSSCP00000012168 | ENSSSCP00000008346 | Cytokine-inducible SH2-containing protein isoform 2. | Interleukin-4 receptor subunit alpha; Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 (By similarity). | 0.407 |
| CISH | JAK2 | ENSSSCP00000012168 | ENSSSCP00000029236 | Cytokine-inducible SH2-containing protein isoform 2. | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] | 0.416 |
| CISH | PRLR | ENSSSCP00000012168 | ENSSSCP00000063211 | Cytokine-inducible SH2-containing protein isoform 2. | Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin. | 0.918 |
| CISH | SOCS1 | ENSSSCP00000012168 | ENSSSCP00000024749 | Cytokine-inducible SH2-containing protein isoform 2. | Suppressor of cytokine signaling 1. | 0.651 |
| CISH | SOCS3 | ENSSSCP00000012168 | ENSSSCP00000051672 | Cytokine-inducible SH2-containing protein isoform 2. | Suppressor of cytokine signaling 3. | 0.653 |
| CISH | SOCS5 | ENSSSCP00000012168 | ENSSSCP00000073830 | Cytokine-inducible SH2-containing protein isoform 2. | Suppressor of cytokine signaling 5. | 0.663 |
| CISH | STAT1 | ENSSSCP00000012168 | ENSSSCP00000033087 | Cytokine-inducible SH2-containing protein isoform 2. | Signal transducer and activator of transcription 1; Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to [...] | 0.925 |
| CISH | STAT2 | ENSSSCP00000012168 | ENSSSCP00000069374 | Cytokine-inducible SH2-containing protein isoform 2. | Signal transducer and activator of transcription 2; Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive [...] | 0.925 |
| CISH | STAT3 | ENSSSCP00000012168 | ENSSSCP00000018439 | Cytokine-inducible SH2-containing protein isoform 2. | Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] | 0.930 |
| CISH | STAT4 | ENSSSCP00000012168 | ENSSSCP00000020218 | Cytokine-inducible SH2-containing protein isoform 2. | Signal transducer and activator of transcription. | 0.924 |
| CISH | STAT5A | ENSSSCP00000012168 | ENSSSCP00000018442 | Cytokine-inducible SH2-containing protein isoform 2. | Signal transducer and activator of transcription 5A; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation (By similarity). | 0.933 |
| CISH | STAT5B | ENSSSCP00000012168 | ENSSSCP00000018443 | Cytokine-inducible SH2-containing protein isoform 2. | Signal transducer and activator of transcription 5B; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation. | 0.932 |
| CISH | STAT6 | ENSSSCP00000012168 | ENSSSCP00000019659 | Cytokine-inducible SH2-containing protein isoform 2. | Signal transducer and activator of transcription. | 0.927 |
| CRLF2 | CSF2RA | ENSSSCP00000046726 | ENSSSCP00000054835 | Cytokine receptor-like factor 2. | Fibronectin type-III domain-containing protein. | 0.554 |
| CRLF2 | IL7R | ENSSSCP00000046726 | ENSSSCP00000028649 | Cytokine receptor-like factor 2. | Fibronectin type-III domain-containing protein. | 0.978 |
| CRLF2 | JAK2 | ENSSSCP00000046726 | ENSSSCP00000029236 | Cytokine receptor-like factor 2. | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] | 0.400 |
| CRLF2 | STAT3 | ENSSSCP00000046726 | ENSSSCP00000018439 | Cytokine receptor-like factor 2. | Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] | 0.519 |
| CRLF2 | TSLP | ENSSSCP00000046726 | ENSSSCP00000015103 | Cytokine receptor-like factor 2. | Uncharacterized protein. | 0.828 |
| CSF2 | CSF2RA | ENSSSCP00000020413 | ENSSSCP00000054835 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Fibronectin type-III domain-containing protein. | 0.991 |
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