(5 nodes) Interleukin-10, conserved site, and Interleukin-10 signaling network (Sus scrofa)

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Your Input:
	IL22	Interleukin 22. (190 aa)
	IL10RA	Interleukin 10 receptor subunit alpha. (576 aa)
	IL10	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (219 aa)
	IL10RB	Interleukin-10 receptor subunit beta. (362 aa)
	IL22RA1	Interleukin 22 receptor subunit alpha 1. (660 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IL10	IL10RA	ENSSSCP00000016594	ENSSSCP00000016008	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 10 receptor subunit alpha.	0.997
IL10	IL10RB	ENSSSCP00000016594	ENSSSCP00000033998	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin-10 receptor subunit beta.	0.992
IL10	IL22	ENSSSCP00000016594	ENSSSCP00000000512	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 22.	0.850
IL10	IL22RA1	ENSSSCP00000016594	ENSSSCP00000047621	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 22 receptor subunit alpha 1.	0.760
IL10RA	IL10	ENSSSCP00000016008	ENSSSCP00000016594	Interleukin 10 receptor subunit alpha.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.997
IL10RA	IL10RB	ENSSSCP00000016008	ENSSSCP00000033998	Interleukin 10 receptor subunit alpha.	Interleukin-10 receptor subunit beta.	0.987
IL10RA	IL22	ENSSSCP00000016008	ENSSSCP00000000512	Interleukin 10 receptor subunit alpha.	Interleukin 22.	0.805
IL10RA	IL22RA1	ENSSSCP00000016008	ENSSSCP00000047621	Interleukin 10 receptor subunit alpha.	Interleukin 22 receptor subunit alpha 1.	0.511
IL10RB	IL10	ENSSSCP00000033998	ENSSSCP00000016594	Interleukin-10 receptor subunit beta.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.992
IL10RB	IL10RA	ENSSSCP00000033998	ENSSSCP00000016008	Interleukin-10 receptor subunit beta.	Interleukin 10 receptor subunit alpha.	0.987
IL10RB	IL22	ENSSSCP00000033998	ENSSSCP00000000512	Interleukin-10 receptor subunit beta.	Interleukin 22.	0.985
IL10RB	IL22RA1	ENSSSCP00000033998	ENSSSCP00000047621	Interleukin-10 receptor subunit beta.	Interleukin 22 receptor subunit alpha 1.	0.974
IL22	IL10	ENSSSCP00000000512	ENSSSCP00000016594	Interleukin 22.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.850
IL22	IL10RA	ENSSSCP00000000512	ENSSSCP00000016008	Interleukin 22.	Interleukin 10 receptor subunit alpha.	0.805
IL22	IL10RB	ENSSSCP00000000512	ENSSSCP00000033998	Interleukin 22.	Interleukin-10 receptor subunit beta.	0.985
IL22	IL22RA1	ENSSSCP00000000512	ENSSSCP00000047621	Interleukin 22.	Interleukin 22 receptor subunit alpha 1.	0.998
IL22RA1	IL10	ENSSSCP00000047621	ENSSSCP00000016594	Interleukin 22 receptor subunit alpha 1.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.760
IL22RA1	IL10RA	ENSSSCP00000047621	ENSSSCP00000016008	Interleukin 22 receptor subunit alpha 1.	Interleukin 10 receptor subunit alpha.	0.511
IL22RA1	IL10RB	ENSSSCP00000047621	ENSSSCP00000033998	Interleukin 22 receptor subunit alpha 1.	Interleukin-10 receptor subunit beta.	0.974
IL22RA1	IL22	ENSSSCP00000047621	ENSSSCP00000000512	Interleukin 22 receptor subunit alpha 1.	Interleukin 22.	0.998