(7 nodes) Growth hormone receptor signaling pathway via JAK-STAT, and SOCS4/SOCS5 domain network (Sus scrofa)

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Your Input:
	CISH	Cytokine-inducible SH2-containing protein isoform 2. (254 aa)
	STAT5A	Signal transducer and activator of transcription 5A; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation (By similarity). (799 aa)
	STAT5B	Signal transducer and activator of transcription 5B; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation. (787 aa)
	STAT6	Signal transducer and activator of transcription. (847 aa)
	JAK3	Tyrosine-protein kinase. (1103 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (447 aa)
	SOCS5	Suppressor of cytokine signaling 5. (536 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CISH	SOCS5	ENSSSCP00000012168	ENSSSCP00000073830	Cytokine-inducible SH2-containing protein isoform 2.	Suppressor of cytokine signaling 5.	0.663
CISH	STAT5A	ENSSSCP00000012168	ENSSSCP00000018442	Cytokine-inducible SH2-containing protein isoform 2.	Signal transducer and activator of transcription 5A; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation (By similarity).	0.933
CISH	STAT5B	ENSSSCP00000012168	ENSSSCP00000018443	Cytokine-inducible SH2-containing protein isoform 2.	Signal transducer and activator of transcription 5B; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation.	0.932
CISH	STAT6	ENSSSCP00000012168	ENSSSCP00000019659	Cytokine-inducible SH2-containing protein isoform 2.	Signal transducer and activator of transcription.	0.927
JAK3	PTPN2	ENSSSCP00000030830	ENSSSCP00000058148	Tyrosine-protein kinase.	Tyrosine-protein phosphatase non-receptor type.	0.943
JAK3	SOCS5	ENSSSCP00000030830	ENSSSCP00000073830	Tyrosine-protein kinase.	Suppressor of cytokine signaling 5.	0.931
JAK3	STAT5A	ENSSSCP00000030830	ENSSSCP00000018442	Tyrosine-protein kinase.	Signal transducer and activator of transcription 5A; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation (By similarity).	0.979
JAK3	STAT5B	ENSSSCP00000030830	ENSSSCP00000018443	Tyrosine-protein kinase.	Signal transducer and activator of transcription 5B; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation.	0.978
JAK3	STAT6	ENSSSCP00000030830	ENSSSCP00000019659	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.982
PTPN2	JAK3	ENSSSCP00000058148	ENSSSCP00000030830	Tyrosine-protein phosphatase non-receptor type.	Tyrosine-protein kinase.	0.943
PTPN2	STAT5A	ENSSSCP00000058148	ENSSSCP00000018442	Tyrosine-protein phosphatase non-receptor type.	Signal transducer and activator of transcription 5A; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation (By similarity).	0.922
PTPN2	STAT5B	ENSSSCP00000058148	ENSSSCP00000018443	Tyrosine-protein phosphatase non-receptor type.	Signal transducer and activator of transcription 5B; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation.	0.922
PTPN2	STAT6	ENSSSCP00000058148	ENSSSCP00000019659	Tyrosine-protein phosphatase non-receptor type.	Signal transducer and activator of transcription.	0.922
SOCS5	CISH	ENSSSCP00000073830	ENSSSCP00000012168	Suppressor of cytokine signaling 5.	Cytokine-inducible SH2-containing protein isoform 2.	0.663
SOCS5	JAK3	ENSSSCP00000073830	ENSSSCP00000030830	Suppressor of cytokine signaling 5.	Tyrosine-protein kinase.	0.931
SOCS5	STAT5A	ENSSSCP00000073830	ENSSSCP00000018442	Suppressor of cytokine signaling 5.	Signal transducer and activator of transcription 5A; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation (By similarity).	0.788
SOCS5	STAT5B	ENSSSCP00000073830	ENSSSCP00000018443	Suppressor of cytokine signaling 5.	Signal transducer and activator of transcription 5B; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation.	0.770
SOCS5	STAT6	ENSSSCP00000073830	ENSSSCP00000019659	Suppressor of cytokine signaling 5.	Signal transducer and activator of transcription.	0.422
STAT5A	CISH	ENSSSCP00000018442	ENSSSCP00000012168	Signal transducer and activator of transcription 5A; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation (By similarity).	Cytokine-inducible SH2-containing protein isoform 2.	0.933
STAT5A	JAK3	ENSSSCP00000018442	ENSSSCP00000030830	Signal transducer and activator of transcription 5A; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation (By similarity).	Tyrosine-protein kinase.	0.979