STRINGSTRING
CD27 CD27 CD274 CD274 CD80 CD80 TNFSF18 TNFSF18 CD40LG CD40LG TNFSF9 TNFSF9 HAVCR2 HAVCR2 ICOS ICOS CD86 CD86 TNFRSF9 TNFRSF9 CTLA4 CTLA4 CD70 CD70 PDCD1 PDCD1 TNFRSF18 TNFRSF18 TNFRSF4 TNFRSF4 LGALS9 LGALS9 CD40 CD40 TNFSF8 TNFSF8 PDCD1LG2 PDCD1LG2 ICOSLG ICOSLG TNFSF4 TNFSF4 CD28 CD28
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD27CD27. (249 aa)
CD274CD274 molecule. (311 aa)
CD80CD80 molecule. (297 aa)
TNFSF18TNF superfamily member 18. (178 aa)
CD40LGCD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (261 aa)
TNFSF9Tumor necrosis factor ligand superfamily member 9; Belongs to the tumor necrosis factor family. (259 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (283 aa)
ICOSIGv domain-containing protein. (209 aa)
CD86T-lymphocyte activation antigen CD86 isoform 1. (337 aa)
TNFRSF9TNF receptor superfamily member 9. (260 aa)
CTLA4Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. (223 aa)
CD70CD70 antigen; Cytokine which is the ligand for CD27. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells; Belongs to the tumor necrosis factor family. (198 aa)
PDCD1Programmed cell death 1. (287 aa)
TNFRSF18TNFR-Cys domain-containing protein. (331 aa)
TNFRSF4TNF receptor superfamily member 4. (278 aa)
LGALS9Uncharacterized protein. (450 aa)
CD40Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). (278 aa)
TNFSF8TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (233 aa)
PDCD1LG2IG domain-containing protein. (290 aa)
ICOSLGIg-like domain-containing protein. (483 aa)
TNFSF4Tumor necrosis factor ligand superfamily member 4 isoform X1; Belongs to the tumor necrosis factor family. (182 aa)
CD28IGv domain-containing protein. (222 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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