STRINGSTRING
IRAK4 IRAK4 NFKBIE NFKBIE NFKBIA NFKBIA RIPK3 RIPK3 BAX BAX NLRP9 NLRP9 CASP9 CASP9 BCL2L10 BCL2L10 IFNB1 IFNB1 IL33 IL33 TRAF1 TRAF1 ENDOG ENDOG TRAF2 TRAF2 LY96 LY96 GSDMD GSDMD IKBKB IKBKB MAVS MAVS CREBBP CREBBP IL1B2 IL1B2 LOC110258578 LOC110258578 IL1A IL1A BCL2L11 BCL2L11 IL18RAP IL18RAP IL1R2 IL1R2 REL REL BIRC6 BIRC6 TNIP2 TNIP2 ANXA5 ANXA5 LOC100624226 LOC100624226 DIABLO DIABLO CHUK CHUK NFKB2 NFKB2 SATB1 SATB1 MYD88 MYD88 TLR9 TLR9 TLR8 TLR8 IRAK1 IRAK1 IRF7 IRF7 RELA RELA F1SV37_PIG F1SV37_PIG LOC100522887 LOC100522887 TLR3 TLR3 CYCS CYCS F1RHI4_PIG F1RHI4_PIG CD68 CD68 FASLG FASLG IKBKE IKBKE TLR6 TLR6 IL1RL2 IL1RL2 I3LCB9_PIG I3LCB9_PIG SIGIRR SIGIRR PXDN PXDN PARP1 PARP1 TLR1 TLR1 NFKBIB NFKBIB LOC100519295 LOC100519295 TLR10 TLR10 TICAM1 TICAM1 CASP8 CASP8 CASP10 CASP10 GPX8 GPX8 PMAIP1 PMAIP1 MAP3K8 MAP3K8 RIPK2 RIPK2 TAB1 TAB1 IRF3 IRF3 TRAF5 TRAF5 IL18BP IL18BP FADD FADD TNFAIP3 TNFAIP3 BAK1 BAK1 LOC110258125 LOC110258125 BCL2L1 BCL2L1 A0A286ZQJ2_PIG A0A286ZQJ2_PIG TRAF6 TRAF6 RELB RELB BCL2A1 BCL2A1 ITIH4 ITIH4 TNFRSF1A TNFRSF1A TAB2 TAB2 CFLAR CFLAR NLRP3 NLRP3 TOLLIP TOLLIP LOC110258582 LOC110258582 HTRA2 HTRA2 XIAP XIAP TRAF4 TRAF4 TNIP1 TNIP1 APAF1 APAF1 BAD BAD IRAK2 IRAK2 IL1B-2 IL1B-2 CASP7 CASP7 TRAF3 TRAF3 BOK BOK LOC110258579 LOC110258579 IL1B IL1B DDX58 DDX58 BMF BMF TBK1 TBK1 PRPS2 PRPS2 TIRAP TIRAP NFKB1 NFKB1 IKBKG IKBKG PYCARD PYCARD BID BID CASP3 CASP3 BIRC3 BIRC3 A0A287AZF5_PIG A0A287AZF5_PIG LOC110255300 LOC110255300 IL1RAP IL1RAP IL1RL1 IL1RL1 MCL1 MCL1 IL18R1 IL18R1 NOD2 NOD2 MAP3K7 MAP3K7 TRADD TRADD PLEKHG6 PLEKHG6 LOC110259156 LOC110259156 RIPK1 RIPK1 IRAK3 IRAK3 TAB3 TAB3 TLR4 TLR4 TLR5 TLR5 CRP CRP UNC93B1 UNC93B1 TNF TNF LOC100627067 LOC100627067 FAS FAS CASP1 CASP1 HMOX1 HMOX1 IL1R1 IL1R1 TRIM25 TRIM25 TLR2 TLR2 CASP6 CASP6 IL18 IL18 BBC3 BBC3 NLRP6 NLRP6 BIRC7-2 BIRC7-2 RNF125 RNF125
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IRAK4Protein kinase domain-containing protein. (459 aa)
NFKBIENFKB inhibitor epsilon. (362 aa)
NFKBIANF-kappa-B inhibitor alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. (314 aa)
RIPK3Receptor-interacting serine/threonine-protein kinase 3; Belongs to the protein kinase superfamily. (493 aa)
BAXTrans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family. (480 aa)
NLRP9NACHT, LRR and PYD domains-containing protein 9 isoform X1. (996 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (438 aa)
BCL2L10Uncharacterized protein. (184 aa)
IFNB1Interferon-beta-1. (186 aa)
IL33Interleukin 33. (276 aa)
TRAF1TNF receptor-associated factor. (415 aa)
ENDOGEndonuclease. (299 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (520 aa)
LY96Lymphocyte antigen 96 isoform 1. (160 aa)
GSDMDGasdermin-D. (488 aa)
IKBKBInhibitor of kappa light chain gene enhancer in B cells, kinase beta. (755 aa)
MAVSMitochondrial antiviral signaling protein. (532 aa)
CREBBPCREB-binding protein isoform a. (2440 aa)
IL1B2Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
LOC110258578Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (270 aa)
BCL2L11Uncharacterized protein. (433 aa)
IL18RAPInterleukin-18 receptor accessory protein. (627 aa)
IL1R2Interleukin 1 receptor type 2. (413 aa)
RELREL proto-oncogene, NF-kB subunit. (586 aa)
BIRC6Baculoviral IAP repeat containing 6. (4843 aa)
TNIP2TNFAIP3 interacting protein 2. (435 aa)
ANXA5Annexin. (321 aa)
LOC100624226Uncharacterized protein. (446 aa)
DIABLOUncharacterized protein. (237 aa)
CHUKProtein kinase domain-containing protein. (580 aa)
NFKB2Nuclear factor NF-kappa-B p100 subunit isoform X1. (901 aa)
SATB1DNA-binding protein SATB. (751 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (323 aa)
TLR9Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1030 aa)
TLR8Toll like receptor 8; Belongs to the Toll-like receptor family. (1117 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (691 aa)
IRF7Interferon regulatory factor 7. (481 aa)
RELATranscription factor p65 isoform 1. (573 aa)
F1SV37_PIGUncharacterized protein; Belongs to the peptidase C14A family. (332 aa)
LOC100522887Uncharacterized protein; Belongs to the peptidase C14A family. (376 aa)
TLR3TIR domain-containing protein; Belongs to the Toll-like receptor family. (903 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
F1RHI4_PIGCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
CD68Macrosialin isoform A. (318 aa)
FASLGTumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance (By similarity). Binds to TNFRSF6B/DcR3, a decoy receptor tha [...] (282 aa)
IKBKEInhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1. (718 aa)
TLR6Toll-like receptor 6; Belongs to the Toll-like receptor family. (796 aa)
IL1RL2Interleukin 1 receptor like 2. (644 aa)
I3LCB9_PIGCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
SIGIRRUncharacterized protein. (410 aa)
PXDNPeroxidasin. (1529 aa)
PARP1Poly [ADP-ribose] polymerase. (1017 aa)
TLR1Toll-like receptor 1; Belongs to the Toll-like receptor family. (796 aa)
NFKBIBNFKB inhibitor beta. (361 aa)
LOC100519295Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
TLR10TIR domain-containing protein; Belongs to the Toll-like receptor family. (810 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (713 aa)
CASP8Caspase-8 isoform X2; Belongs to the peptidase C14A family. (486 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (520 aa)
GPX8Glutathione peroxidase; Belongs to the glutathione peroxidase family. (158 aa)
PMAIP1Uncharacterized protein. (121 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (496 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (533 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (604 aa)
IRF3Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactiv [...] (452 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
IL18BPInterleukin 18 binding protein. (188 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3 isoform X1. (785 aa)
BAK1Uncharacterized protein. (266 aa)
LOC110258125Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
BCL2L1Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...] (233 aa)
A0A286ZQJ2_PIGCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (106 aa)
TRAF6TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (541 aa)
RELBRELB proto-oncogene, NF-kB subunit. (574 aa)
BCL2A1Bcl-2-related protein A1 isoform 1. (175 aa)
ITIH4Inter-alpha-trypsin inhibitor heavy chain H4; Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration. (976 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A; Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity). (464 aa)
TAB2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1. (692 aa)
CFLARCASP8 and FADD-like apoptosis regulator isoform 1; Belongs to the peptidase C14A family. (509 aa)
NLRP3NACHT, LRR and PYD domains-containing protein 3 isoform X1. (1036 aa)
TOLLIPCUE domain-containing protein. (272 aa)
LOC110258582Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (245 aa)
HTRA2HtrA serine peptidase 2. (444 aa)
XIAPX-linked inhibitor of apoptosis. (514 aa)
TRAF4TNF receptor-associated factor. (470 aa)
TNIP1TNFAIP3 interacting protein 1. (715 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1249 aa)
BADBCL2 associated agonist of cell death. (209 aa)
IRAK2Interleukin-1 receptor-associated kinase-like 2. (621 aa)
IL1B-2Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (244 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (382 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa)
BOKBCL2 family apoptosis regulator BOK. (288 aa)
LOC110258579Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (272 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. (267 aa)
DDX58Antiviral innate immune response receptor RIG-I; Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Up [...] (943 aa)
BMFBcl2 modifying factor. (183 aa)
TBK1TANK binding kinase TBK1. (729 aa)
PRPS2TIR domain-containing protein. (1337 aa)
TIRAPTIR domain containing adaptor protein. (243 aa)
NFKB1Uncharacterized protein. (898 aa)
IKBKGNF-kappa-B essential modulator; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activati [...] (451 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD isoform a. (196 aa)
BIDBH3-interacting domain death agonist p11; Induces caspases and apoptosis. Counters the protective effect of Bcl-2. The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). (205 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). (266 aa)
BIRC3Baculoviral IAP repeat containing 3. (603 aa)
A0A287AZF5_PIGCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC110255300Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
IL1RAPInterleukin-1 receptor accessory protein isoform 3. (685 aa)
IL1RL1Interleukin 1 receptor like 1. (573 aa)
MCL1Induced myeloid leukemia cell differentiation protein Mcl-1. (351 aa)
IL18R1Interleukin 18 receptor 1. (539 aa)
NOD2Uncharacterized protein. (1013 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (304 aa)
PLEKHG6Pleckstrin homology domain-containing family G member 6 isoform X1. (791 aa)
LOC110259156Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (668 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (752 aa)
TAB3TGF-beta-activated kinase 1 and MAP3K7-binding protein 3. (717 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (841 aa)
TLR5TIR domain-containing protein; Belongs to the Toll-like receptor family. (855 aa)
CRPC-reactive protein; Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells (By similarity); Belongs to the pentraxin family. (266 aa)
UNC93B1Unc-93 homolog B1, TLR signaling regulator. (761 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
LOC100627067Uncharacterized protein. (518 aa)
FASTumor necrosis factor receptor superfamily member 6; Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen- stimulated suicide of mature T-cells, or both (By similarity). (428 aa)
CASP1Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...] (406 aa)
HMOX1Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis. (287 aa)
IL1R1Interleukin-1 receptor type 1 isoform 1. (572 aa)
TRIM25Tripartite motif containing 25. (633 aa)
TLR2Toll-like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
CASP6Caspase 6; Belongs to the peptidase C14A family. (292 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (201 aa)
BBC3Uncharacterized protein. (361 aa)
NLRP6NLR family pyrin domain containing 6. (891 aa)
BIRC7-2Uncharacterized protein. (428 aa)
RNF125Ring finger protein 125. (364 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.