(11 nodes) Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, and Caspase recruitment domain network (Sus scrofa)

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Your Input:
	IFNB1	Interferon-beta-1. (186 aa)
	MAVS	Mitochondrial antiviral signaling protein. (532 aa)
	CREBBP	CREB-binding protein isoform a. (2440 aa)
	IRF7	Interferon regulatory factor 7. (481 aa)
	IKBKE	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1. (718 aa)
	IRF3	Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactiv [...] (452 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa)
	DDX58	Antiviral innate immune response receptor RIG-I; Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Up [...] (943 aa)
	TBK1	TANK binding kinase TBK1. (729 aa)
	TRIM25	Tripartite motif containing 25. (633 aa)
	RNF125	Ring finger protein 125. (364 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CREBBP	IFNB1	ENSSSCP00000008490	ENSSSCP00000005550	CREB-binding protein isoform a.	Interferon-beta-1.	0.545
CREBBP	IRF3	ENSSSCP00000008490	ENSSSCP00000028920	CREB-binding protein isoform a.	Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactiv [...]	0.999
CREBBP	IRF7	ENSSSCP00000008490	ENSSSCP00000013664	CREB-binding protein isoform a.	Interferon regulatory factor 7.	0.964
CREBBP	TBK1	ENSSSCP00000008490	ENSSSCP00000046241	CREB-binding protein isoform a.	TANK binding kinase TBK1.	0.419
DDX58	IFNB1	ENSSSCP00000045260	ENSSSCP00000005550	Antiviral innate immune response receptor RIG-I; Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Up [...]	Interferon-beta-1.	0.914
DDX58	IKBKE	ENSSSCP00000045260	ENSSSCP00000019776	Antiviral innate immune response receptor RIG-I; Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Up [...]	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1.	0.527
DDX58	IRF3	ENSSSCP00000045260	ENSSSCP00000028920	Antiviral innate immune response receptor RIG-I; Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Up [...]	Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactiv [...]	0.926
DDX58	IRF7	ENSSSCP00000045260	ENSSSCP00000013664	Antiviral innate immune response receptor RIG-I; Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Up [...]	Interferon regulatory factor 7.	0.865
DDX58	MAVS	ENSSSCP00000045260	ENSSSCP00000007605	Antiviral innate immune response receptor RIG-I; Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Up [...]	Mitochondrial antiviral signaling protein.	0.999
DDX58	RNF125	ENSSSCP00000045260	ENSSSCP00000073490	Antiviral innate immune response receptor RIG-I; Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Up [...]	Ring finger protein 125.	0.950
DDX58	TBK1	ENSSSCP00000045260	ENSSSCP00000046241	Antiviral innate immune response receptor RIG-I; Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Up [...]	TANK binding kinase TBK1.	0.922
DDX58	TRAF3	ENSSSCP00000045260	ENSSSCP00000043474	Antiviral innate immune response receptor RIG-I; Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Up [...]	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.771
DDX58	TRIM25	ENSSSCP00000045260	ENSSSCP00000067922	Antiviral innate immune response receptor RIG-I; Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Up [...]	Tripartite motif containing 25.	0.988
IFNB1	CREBBP	ENSSSCP00000005550	ENSSSCP00000008490	Interferon-beta-1.	CREB-binding protein isoform a.	0.545
IFNB1	DDX58	ENSSSCP00000005550	ENSSSCP00000045260	Interferon-beta-1.	Antiviral innate immune response receptor RIG-I; Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Up [...]	0.914
IFNB1	IKBKE	ENSSSCP00000005550	ENSSSCP00000019776	Interferon-beta-1.	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1.	0.522
IFNB1	IRF3	ENSSSCP00000005550	ENSSSCP00000028920	Interferon-beta-1.	Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactiv [...]	0.930
IFNB1	IRF7	ENSSSCP00000005550	ENSSSCP00000013664	Interferon-beta-1.	Interferon regulatory factor 7.	0.986
IFNB1	MAVS	ENSSSCP00000005550	ENSSSCP00000007605	Interferon-beta-1.	Mitochondrial antiviral signaling protein.	0.898
IFNB1	TBK1	ENSSSCP00000005550	ENSSSCP00000046241	Interferon-beta-1.	TANK binding kinase TBK1.	0.937