(29 nodes) Mixed, incl. Negative regulation of viral genome replication, and Z-binding domain network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ZBP1	Uncharacterized protein. (438 aa)
	OAS2	2'-5'-oligoadenylate synthetase 2. (713 aa)
	OASL	2'-5'-oligoadenylate synthase-like protein isoform a. (348 aa)
	IFIT1	Interferon-stimulated protein 60. (509 aa)
	DHX58	DExH-box helicase 58. (681 aa)
	HERC5	HECT and RLD domain containing E3 ubiquitin protein ligase 5. (968 aa)
	ISG20	Interferon stimulated exonuclease gene 20. (189 aa)
	I3LFU3_PIG	RING-type domain-containing protein. (2080 aa)
	MX1	Interferon-induced GTP-binding protein Mx1; Interferon-induced dynamin-like GTPase with antiviral activity against influenza A virus, (IAV). Inhibits IAV replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. (650 aa)
	IFIT2	Interferon induced protein with tetratricopeptide repeats 2. (473 aa)
	EPSTI1	Epithelial-stromal interaction protein 1 isoform X1. (304 aa)
	IFI44	G domain-containing protein. (438 aa)
	GBP1	GB1/RHD3-type G domain-containing protein. (614 aa)
	IFI44L	Interferon induced protein 44 like. (418 aa)
	ISG15	Ubiquitin-like modifier. (167 aa)
	IFIH1	Interferon induced with helicase C domain 1. (1023 aa)
	IFI6	Interferon alpha inducible protein 6. (171 aa)
	USP18	USP domain-containing protein; Belongs to the peptidase C19 family. (376 aa)
	RSAD2	Radical S-adenosyl methionine domain-containing protein 2; Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of viruses, including west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus and vesicular stomatitis virus (VSV). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, thro [...] (362 aa)
	SAMD9	Sterile alpha motif domain containing 9. (1596 aa)
	RTP4	Receptor-transporting protein 4. (550 aa)
	MX2	Interferon-induced GTP-binding protein Mx2; Interferon-induced dynamin-like GTPase with antiviral activity against influenza virus A (FLUAV). Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (711 aa)
	EIF2AK2	Eukaryotic translation initiation factor 2 alpha kinase 2. (546 aa)
	IFITM3	Uncharacterized protein. (206 aa)
	ADAR	Adenosine deaminase RNA specific. (1169 aa)
	OAS1	2'-5'-oligoadenylate synthase 1. (334 aa)
	DDX60	Putative ATP-dependent RNA helicase DDX60 isoform X1. (1704 aa)
	GBP2	GB1/RHD3-type G domain-containing protein. (590 aa)
	IFIT5	Interferon induced protein with tetratricopeptide repeats 5. (489 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAR	DHX58	ENSSSCP00000062912	ENSSSCP00000018455	Adenosine deaminase RNA specific.	DExH-box helicase 58.	0.568
ADAR	EIF2AK2	ENSSSCP00000062912	ENSSSCP00000057073	Adenosine deaminase RNA specific.	Eukaryotic translation initiation factor 2 alpha kinase 2.	0.591
ADAR	HERC5	ENSSSCP00000062912	ENSSSCP00000020915	Adenosine deaminase RNA specific.	HECT and RLD domain containing E3 ubiquitin protein ligase 5.	0.573
ADAR	IFIH1	ENSSSCP00000062912	ENSSSCP00000044491	Adenosine deaminase RNA specific.	Interferon induced with helicase C domain 1.	0.521
ADAR	IFIT1	ENSSSCP00000062912	ENSSSCP00000011141	Adenosine deaminase RNA specific.	Interferon-stimulated protein 60.	0.407
ADAR	IFIT2	ENSSSCP00000062912	ENSSSCP00000029516	Adenosine deaminase RNA specific.	Interferon induced protein with tetratricopeptide repeats 2.	0.659
ADAR	IFIT5	ENSSSCP00000062912	ENSSSCP00000069825	Adenosine deaminase RNA specific.	Interferon induced protein with tetratricopeptide repeats 5.	0.659
ADAR	ISG15	ENSSSCP00000062912	ENSSSCP00000041015	Adenosine deaminase RNA specific.	Ubiquitin-like modifier.	0.510
ADAR	ISG20	ENSSSCP00000062912	ENSSSCP00000021223	Adenosine deaminase RNA specific.	Interferon stimulated exonuclease gene 20.	0.409
ADAR	MX1	ENSSSCP00000062912	ENSSSCP00000029166	Adenosine deaminase RNA specific.	Interferon-induced GTP-binding protein Mx1; Interferon-induced dynamin-like GTPase with antiviral activity against influenza A virus, (IAV). Inhibits IAV replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles.	0.702
ADAR	MX2	ENSSSCP00000062912	ENSSSCP00000055951	Adenosine deaminase RNA specific.	Interferon-induced GTP-binding protein Mx2; Interferon-induced dynamin-like GTPase with antiviral activity against influenza virus A (FLUAV). Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.507
ADAR	OAS1	ENSSSCP00000062912	ENSSSCP00000064281	Adenosine deaminase RNA specific.	2'-5'-oligoadenylate synthase 1.	0.623
ADAR	OAS2	ENSSSCP00000062912	ENSSSCP00000010548	Adenosine deaminase RNA specific.	2'-5'-oligoadenylate synthetase 2.	0.563
ADAR	RSAD2	ENSSSCP00000062912	ENSSSCP00000052007	Adenosine deaminase RNA specific.	Radical S-adenosyl methionine domain-containing protein 2; Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of viruses, including west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus and vesicular stomatitis virus (VSV). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, thro [...]	0.513
DDX60	DHX58	ENSSSCP00000066827	ENSSSCP00000018455	Putative ATP-dependent RNA helicase DDX60 isoform X1.	DExH-box helicase 58.	0.791
DDX60	EIF2AK2	ENSSSCP00000066827	ENSSSCP00000057073	Putative ATP-dependent RNA helicase DDX60 isoform X1.	Eukaryotic translation initiation factor 2 alpha kinase 2.	0.415
DDX60	EPSTI1	ENSSSCP00000066827	ENSSSCP00000034513	Putative ATP-dependent RNA helicase DDX60 isoform X1.	Epithelial-stromal interaction protein 1 isoform X1.	0.584
DDX60	HERC5	ENSSSCP00000066827	ENSSSCP00000020915	Putative ATP-dependent RNA helicase DDX60 isoform X1.	HECT and RLD domain containing E3 ubiquitin protein ligase 5.	0.452
DDX60	IFI44	ENSSSCP00000066827	ENSSSCP00000036739	Putative ATP-dependent RNA helicase DDX60 isoform X1.	G domain-containing protein.	0.678
DDX60	IFI6	ENSSSCP00000066827	ENSSSCP00000048654	Putative ATP-dependent RNA helicase DDX60 isoform X1.	Interferon alpha inducible protein 6.	0.444