STRINGSTRING
LY49 LY49 LOC100523789 LOC100523789 SLA-6 SLA-6 HLA-DRA HLA-DRA HLA-DOB HLA-DOB TAP2 TAP2 TAP1 TAP1 SLA-DMB SLA-DMB SLA-DOA SLA-DOA CSK CSK NKG7 NKG7 OSBPL1A OSBPL1A FYN FYN CD244 CD244 LY9 LY9 CD48 CD48 CD84 CD84 SLAMF6 SLAMF6 SLAMF8 SLAMF8 SLAMF9 SLAMF9 CD58 CD58 PTPN22 PTPN22 CD53 CD53 CD8B CD8B ABCB9 ABCB9 SH2D1A SH2D1A PTPRCAP PTPRCAP CD5 CD5 CD3E CD3E GZMA GZMA GZMA-2 GZMA-2 CD180 CD180 CD4 CD4 LAPTM5 LAPTM5 I3LAQ5_PIG I3LAQ5_PIG LAPTM4A LAPTM4A CD1D CD1D CD3D CD3D K7GNK3_PIG K7GNK3_PIG SLAMF1 SLAMF1 CD6 CD6 ZAP70 ZAP70 CD247 CD247 CD2 CD2 SLA-DMA SLA-DMA A0A286ZKB7_PIG A0A286ZKB7_PIG RAB7A RAB7A CORO1A CORO1A A0A286ZXB7_PIG A0A286ZXB7_PIG AIF1 AIF1 CTSW CTSW PTPRC PTPRC CD8A CD8A A0A287AAB9_PIG A0A287AAB9_PIG PEA15 PEA15 A0A287AC24_PIG A0A287AC24_PIG CD3G CD3G LCK LCK KIR2DL1 KIR2DL1 LY86 LY86 ARHGAP30 ARHGAP30 A0A287ARF7_PIG A0A287ARF7_PIG A0A287AT33_PIG A0A287AT33_PIG PAG1 PAG1 PRF1 PRF1 SLA-8 SLA-8 LOC102158035 LOC102158035 B2M B2M TMEM50B TMEM50B SLA-2 SLA-2 SLA-DRB1 SLA-DRB1 NRROS NRROS TRAV16 TRAV16 CD7 CD7 A0A287BPL5_PIG A0A287BPL5_PIG A0A287BQ00_PIG A0A287BQ00_PIG A0A287BQ31_PIG A0A287BQ31_PIG SAMSN1 SAMSN1 LAPTM4B LAPTM4B SLA-DQB1 SLA-DQB1 CD37 CD37 A0A5G2QNP5_PIG A0A5G2QNP5_PIG MR1 MR1 RILP RILP ZBTB22 ZBTB22 SLA SLA LOC100525572 LOC100525572 GNLY GNLY A0A5G2R5H2_PIG A0A5G2R5H2_PIG SLA-DQA1 SLA-DQA1 EDDM3B EDDM3B LOC110261595 LOC110261595 KLRD1 KLRD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LY49C-type lectin domain-containing protein. (261 aa)
LOC100523789C-type lectin domain-containing protein. (230 aa)
SLA-6Ig-like domain-containing protein; Belongs to the MHC class I family. (462 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (252 aa)
HLA-DOBHLA class II histocompatibility antigen, DO beta chain. (277 aa)
TAP2Uncharacterized protein. (726 aa)
TAP1Transporter 1, ATP binding cassette subfamily B member. (718 aa)
SLA-DMBMajor histocompatibility complex, class II, DM beta. (272 aa)
SLA-DOAIg-like domain-containing protein; Belongs to the MHC class II family. (360 aa)
CSKTyrosine-protein kinase. (474 aa)
NKG7Uncharacterized protein. (165 aa)
OSBPL1AOxysterol-binding protein; Belongs to the OSBP family. (949 aa)
FYNTyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] (537 aa)
CD244CD244 molecule. (369 aa)
LY9Lymphocyte antigen 9. (631 aa)
CD48CD48 antigen isoform X1. (243 aa)
CD84CD84 molecule. (338 aa)
SLAMF6SLAM family member 6. (321 aa)
SLAMF8SLAM family member 8 isoform X1. (295 aa)
SLAMF9SLAM family member 9. (369 aa)
CD58Uncharacterized protein. (243 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (821 aa)
CD53Tetraspanin. (219 aa)
CD8BIg-like domain-containing protein. (260 aa)
ABCB9ATP-binding cassette sub-family B member 9 isoform X1. (768 aa)
SH2D1ASH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1. Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Ca [...] (128 aa)
PTPRCAPProtein tyrosine phosphatase receptor type C associated protein. (208 aa)
CD5T-cell surface glycoprotein CD5 isoform 1. (497 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...] (267 aa)
GZMAGranzyme A; Belongs to the peptidase S1 family. (258 aa)
GZMA-2Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (259 aa)
CD180Lymphocyte antigen 64-like protein. (661 aa)
CD4CD4 molecule. (494 aa)
LAPTM5Lysosomal protein transmembrane 5. (264 aa)
I3LAQ5_PIGIg-like domain-containing protein. (164 aa)
LAPTM4ALysosomal-associated transmembrane protein 4A isoform X1. (233 aa)
CD1DIg-like domain-containing protein. (463 aa)
CD3DT-cell surface glycoprotein CD3 delta chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of [...] (171 aa)
K7GNK3_PIGIg-like domain-containing protein; Belongs to the MHC class I family. (349 aa)
SLAMF1Ig-like domain-containing protein. (379 aa)
CD6CD6 molecule. (671 aa)
ZAP70Tyrosine-protein kinase. (615 aa)
CD247T-cell surface glycoprotein CD3 zeta chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of d [...] (168 aa)
CD2T-cell surface antigen CD2 isoform 2. (370 aa)
SLA-DMAIg-like domain-containing protein; Belongs to the MHC class II family. (290 aa)
A0A286ZKB7_PIGIg-like domain-containing protein. (259 aa)
RAB7ARAB7A, member RAS oncogene family. (252 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (492 aa)
A0A286ZXB7_PIGMHC_I-like_Ag-recog domain-containing protein. (326 aa)
AIF1Allograft inflammatory factor 1; Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation (By similarity). Has a dual influence on glucose-induced insulin secretion: inhibition at low concentration and stimulation at high concentrations. (147 aa)
CTSWCathepsin W; Belongs to the peptidase C1 family. (368 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1092 aa)
CD8ACD8a molecule. (237 aa)
A0A287AAB9_PIGIg-like domain-containing protein. (252 aa)
PEA15Proliferation and apoptosis adaptor protein 15. (157 aa)
A0A287AC24_PIGIg-like domain-containing protein. (112 aa)
CD3GT-cell surface glycoprotein CD3 gamma chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of [...] (176 aa)
LCKTyrosine-protein kinase. (520 aa)
KIR2DL1Ig-like domain-containing protein. (336 aa)
LY86ML domain-containing protein. (197 aa)
ARHGAP30Rho GTPase activating protein 30. (1071 aa)
A0A287ARF7_PIGIg-like domain-containing protein. (139 aa)
A0A287AT33_PIGIg-like domain-containing protein. (173 aa)
PAG1Phosphoprotein membrane anchor with glycosphingolipid microdomains 1. (435 aa)
PRF1Perforin 1. (555 aa)
SLA-8Ig-like domain-containing protein; Belongs to the MHC class I family. (434 aa)
LOC102158035Ig-like domain-containing protein. (268 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (157 aa)
TMEM50BTransmembrane protein 50B isoform X1. (158 aa)
SLA-2Ig-like domain-containing protein; Belongs to the MHC class I family. (394 aa)
SLA-DRB1Ig-like domain-containing protein. (307 aa)
NRROSNegative regulator of reactive oxygen species. (704 aa)
TRAV16T cell receptor alpha variable 16. (166 aa)
CD7Ig-like domain-containing protein. (206 aa)
A0A287BPL5_PIGIg-like domain-containing protein. (154 aa)
A0A287BQ00_PIGIg-like domain-containing protein. (194 aa)
A0A287BQ31_PIGIg-like domain-containing protein. (180 aa)
SAMSN1SAM domain, SH3 domain and nuclear localization signals 1. (665 aa)
LAPTM4BLysosomal protein transmembrane 4 beta. (285 aa)
SLA-DQB1SLA class II histocompatibility antigen, DQ haplotype C beta chain. (271 aa)
CD37Tetraspanin. (379 aa)
A0A5G2QNP5_PIGUncharacterized protein. (271 aa)
MR1Major histocompatibility complex, class I-related; Belongs to the MHC class I family. (347 aa)
RILPRab interacting lysosomal protein. (362 aa)
ZBTB22Zinc finger and BTB domain containing 22. (639 aa)
SLASH2 domain-containing protein. (403 aa)
LOC100525572Ig-like domain-containing protein. (353 aa)
GNLYAntimicrobial peptide NK-lysin; May be an effector molecule of cytotoxic activity. High activity against E.coli and B.megaterium, moderate against A.calcoaceticus and S.pyogenes. No activity against P.aeruginosa, S.aureus and Salmonella. Has some antifungal activity against C.albicans. (210 aa)
A0A5G2R5H2_PIGUncharacterized protein. (261 aa)
SLA-DQA1SLA class II histocompatibility antigen, DQ haplotype D alpha chain. (255 aa)
EDDM3BRibonuclease K3; Ribonuclease which shows a preference for the pyrimidines uridine and cytosine. Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli (By similarity). Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram- negative bacteria (By similarity). Probably contributes to urinary tract sterility (By similarity). Bactericidal activity is independent of RNase activity (By similarity). (153 aa)
LOC110261595Ig-like domain-containing protein. (290 aa)
KLRD1Killer cell lectin like receptor D1. (175 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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