STRINGSTRING
F5 F5 FGB FGB FGA FGA F10 F10 SERPIND1 SERPIND1 F2 F2 FGG FGG APOH APOH AMBP AMBP SERPINA5 SERPINA5 SERPINF2 SERPINF2 AHSG AHSG F13B F13B SERPINC1 SERPINC1 PLG PLG F13A1 F13A1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
F5Coagulation factor V heavy chain; Coagulation factor V is a cofactor that participates with factor Xa to activate prothrombin to thrombin; Belongs to the multicopper oxidase family. (2258 aa)
FGBFibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it i [...] (534 aa)
FGAFibrinogen alpha chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it [...] (924 aa)
F10Uncharacterized protein. (536 aa)
SERPIND1Serpin family D member 1; Belongs to the serpin family. (517 aa)
F2Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). (623 aa)
FGGFibrinogen gamma chain. (454 aa)
APOHBeta-2-glycoprotein 1. (345 aa)
AMBPInter-alpha-trypsin inhibitor light chain; Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization; In the N-terminal section; belongs to the calycin superfamily. Lipocalin family. (364 aa)
SERPINA5Plasma serine protease inhibitor preproprotein; Belongs to the serpin family. (408 aa)
SERPINF2Alpha-2-antiplasmin isoform X2; Belongs to the serpin family. (563 aa)
AHSGAlpha-2-HS-glycoprotein. (394 aa)
F13BCoagulation factor XIII B chain. (663 aa)
SERPINC1SERPIN domain-containing protein; Belongs to the serpin family. (431 aa)
PLGPlasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...] (816 aa)
F13A1Coagulation factor XIII A chain. (774 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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