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OLR1 OLR1 MYLIP MYLIP APOE APOE ANGPTL3 ANGPTL3 ABCA1 ABCA1 PLTP PLTP LOC102157603 LOC102157603 MTTP MTTP SCARB1 SCARB1 ANGPTL4 ANGPTL4 PON2 PON2 RELN RELN COIL COIL PCSK9 PCSK9 LCAT LCAT APOC2 APOC2 APOA1 APOA1 LRP8 LRP8 LMF1 LMF1 GPIHBP1 GPIHBP1 ANGPTL8 ANGPTL8 PON3 PON3 APOB APOB SAA2 SAA2 APOM APOM PON1 PON1 DAB1 DAB1 CLU CLU ABCG1 ABCG1 VLDLR VLDLR APOA4 APOA4 APOC3 APOC3 HPS5 HPS5 SAA4 SAA4 LDLRAP1 LDLRAP1 APOA2 APOA2 LDLR LDLR
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
OLR1Oxidized low-density lipoprotein receptor 1, soluble form; Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses includin [...] (272 aa)
MYLIPMyosin regulatory light chain interacting protein. (445 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (292 aa)
ANGPTL3Fibrinogen C-terminal domain-containing protein. (461 aa)
ABCA1Uncharacterized protein. (2261 aa)
PLTPPhospholipid transfer protein. (496 aa)
LOC102157603Uncharacterized protein. (3265 aa)
MTTPMicrosomal triglyceride transfer protein large subunit; Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. (894 aa)
SCARB1Scavenger receptor class B member 1; Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB- containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. (509 aa)
ANGPTL4Angiopoietin-related protein 4; Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage (By similarity). Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stre [...] (412 aa)
PON2Serum paraoxonase/arylesterase 2 isoform 1. (354 aa)
RELNReelin. (3458 aa)
COILCoilin. (531 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9. (678 aa)
LCATPhosphatidylcholine-sterol acyltransferase. (471 aa)
APOC2Uncharacterized protein. (198 aa)
APOA1Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. (279 aa)
LRP8LDL receptor related protein 8. (998 aa)
LMF1Lipase maturation factor; Involved in the maturation of specific proteins in the endoplasmic reticulum; Belongs to the lipase maturation factor family. (565 aa)
GPIHBP1Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1. (180 aa)
ANGPTL8Angiopoietin-like protein 8. (198 aa)
PON3Paraoxonase 3. (354 aa)
APOBApolipoprotein B-100. (4573 aa)
SAA2Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (122 aa)
APOMApolipoprotein M; Probably involved in lipid transport. Can bind sphingosine-1- phosphate, myristic acid, palmitic acid and stearic acid, retinol, all- trans-retinoic acid and 9-cis-retinoic acid (By similarity). (200 aa)
PON1Paraoxonase 1. (355 aa)
DAB1Disabled homolog 1 isoform 1. (553 aa)
CLUClusterin alpha chain; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysos [...] (472 aa)
ABCG1ATP binding cassette subfamily G member 1. (679 aa)
VLDLRVery low density lipoprotein receptor. (872 aa)
APOA4Apolipoprotein A-IV; May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons. (392 aa)
APOC3Apolipoprotein C-III; Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tigh [...] (199 aa)
HPS5Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (164 aa)
SAA4Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (138 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (336 aa)
APOA2Apolipoprotein A-II preproprotein. (100 aa)
LDLRLow-density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. (878 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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