(32 nodes) Mixed, incl. Antimicrobial peptides, and Cathelicidin network (Sus scrofa)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	CD177	CD177 molecule. (438 aa)
	CYM	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (385 aa)
	CSN2	Beta-casein; Important role in determination of the surface properties of the casein micelles. (231 aa)
	A0A5S6G633_PIG	Alpha-S1-casein. (180 aa)
	CSN3	Kappa-casein; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk. (187 aa)
	LOC100517051	Uncharacterized protein; Belongs to the glycosyl hydrolase 22 family. (148 aa)
	LOC100736951	Uncharacterized protein. (177 aa)
	AZU1	Azurocidin; This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin; Belongs to the peptidase S1 family. Elastase subfamily. (246 aa)
	PRTN3	Proteinase 3; Belongs to the peptidase S1 family. (268 aa)
	MMP8	Matrix metallopeptidase 8. (468 aa)
	EPX	Eosinophil peroxidase heavy chain; Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils; Belongs to the peroxidase family. XPO subfamily. (705 aa)
	DEFB1	Beta-defensin 1. (69 aa)
	ELANE	Elastase, neutrophil expressed; Belongs to the peptidase S1 family. (271 aa)
	DEFB1-2	Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility. (64 aa)
	I3LP35_PIG	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (253 aa)
	LTF	Lactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-\|- and -Arg-Arg-Ser-Arg-\|-, and of Z-Phe-Arg-\|-aminomethylcoumarin sites. (704 aa)
	S100A9	EF-hand domain-containing protein; Belongs to the S-100 family. (222 aa)
	S100A8	Protein S100; Belongs to the S-100 family. (89 aa)
	MPO	Myeloperoxidase. (731 aa)
	PGLYRP1	20 kDa neutrophil cationic protein. (222 aa)
	S100A12	Protein S100-A12; S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF- kappa-B signaling pathways leadi [...] (95 aa)
	LOC102163838	Non-secretory ribonuclease; This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Possesses a wide variety of biological activities (By similarity). (156 aa)
	NPG1	Prophenin-2; Exerts antimicrobial activity. It is more effective against Gram-negative bacteria than Gram-positive bacteria; Belongs to the cathelicidin family. (258 aa)
	LYZ	Lysozyme C-2; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. (136 aa)
	PAEP	Beta-lactoglobulin-1A/1C; Lactoglobulin is the primary component of whey, it binds retinol and is probably involved in the transport of that molecule. (268 aa)
	ALB	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (659 aa)
	LOC100154047	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (353 aa)
	BPI	Bactericidal permeability increasing protein. (486 aa)
	PMAP-36	Antibacterial peptide PMAP-36; Exerts antimicrobial activity against both Gram-positive and negative bacteria. Its activity appears to be mediated by its ability to damage bacterial membranes; Belongs to the cathelicidin family. (166 aa)
	LOC102159373	Uncharacterized protein. (175 aa)
	LPO	Lactoperoxidase isoform 1 preproprotein. (712 aa)
	LOC110255221	Antibacterial peptide PMAP-37; Exerts antimicrobial activity against both Gram-positive and negative bacteria with minimal inhibitory concentrations ranging over 1-4 micro molar. Its activity appears to be mediated by its ability to damage bacterial membranes; Belongs to the cathelicidin family. (167 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A5S6G633_PIG	ALB	ENSSSCP00000009877	ENSSSCP00000053712	Alpha-S1-casein.	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	0.403
A0A5S6G633_PIG	CSN2	ENSSSCP00000009877	ENSSSCP00000009875	Alpha-S1-casein.	Beta-casein; Important role in determination of the surface properties of the casein micelles.	0.976
A0A5S6G633_PIG	CSN3	ENSSSCP00000009877	ENSSSCP00000009882	Alpha-S1-casein.	Kappa-casein; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.	0.950
A0A5S6G633_PIG	CYM	ENSSSCP00000009877	ENSSSCP00000007256	Alpha-S1-casein.	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	0.780
A0A5S6G633_PIG	LPO	ENSSSCP00000009877	ENSSSCP00000067087	Alpha-S1-casein.	Lactoperoxidase isoform 1 preproprotein.	0.499
A0A5S6G633_PIG	LTF	ENSSSCP00000009877	ENSSSCP00000026769	Alpha-S1-casein.	Lactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-\|- and -Arg-Arg-Ser-Arg-\|-, and of Z-Phe-Arg-\|-aminomethylcoumarin sites.	0.720
A0A5S6G633_PIG	PAEP	ENSSSCP00000009877	ENSSSCP00000044067	Alpha-S1-casein.	Beta-lactoglobulin-1A/1C; Lactoglobulin is the primary component of whey, it binds retinol and is probably involved in the transport of that molecule.	0.694
ALB	A0A5S6G633_PIG	ENSSSCP00000053712	ENSSSCP00000009877	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Alpha-S1-casein.	0.403
ALB	CSN2	ENSSSCP00000053712	ENSSSCP00000009875	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Beta-casein; Important role in determination of the surface properties of the casein micelles.	0.784
ALB	CSN3	ENSSSCP00000053712	ENSSSCP00000009882	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Kappa-casein; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.	0.675
ALB	CYM	ENSSSCP00000053712	ENSSSCP00000007256	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	0.408
ALB	ELANE	ENSSSCP00000053712	ENSSSCP00000024494	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Elastase, neutrophil expressed; Belongs to the peptidase S1 family.	0.442
ALB	EPX	ENSSSCP00000053712	ENSSSCP00000018684	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Eosinophil peroxidase heavy chain; Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils; Belongs to the peroxidase family. XPO subfamily.	0.408
ALB	LPO	ENSSSCP00000053712	ENSSSCP00000067087	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Lactoperoxidase isoform 1 preproprotein.	0.597
ALB	LTF	ENSSSCP00000053712	ENSSSCP00000026769	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Lactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-\|- and -Arg-Arg-Ser-Arg-\|-, and of Z-Phe-Arg-\|-aminomethylcoumarin sites.	0.969
ALB	MPO	ENSSSCP00000053712	ENSSSCP00000030636	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Myeloperoxidase.	0.674
ALB	PAEP	ENSSSCP00000053712	ENSSSCP00000044067	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Beta-lactoglobulin-1A/1C; Lactoglobulin is the primary component of whey, it binds retinol and is probably involved in the transport of that molecule.	0.999
AZU1	BPI	ENSSSCP00000014264	ENSSSCP00000057155	Azurocidin; This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin; Belongs to the peptidase S1 family. Elastase subfamily.	Bactericidal permeability increasing protein.	0.662
AZU1	CD177	ENSSSCP00000014264	ENSSSCP00000003305	Azurocidin; This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin; Belongs to the peptidase S1 family. Elastase subfamily.	CD177 molecule.	0.463
AZU1	ELANE	ENSSSCP00000014264	ENSSSCP00000024494	Azurocidin; This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin; Belongs to the peptidase S1 family. Elastase subfamily.	Elastase, neutrophil expressed; Belongs to the peptidase S1 family.	0.683