(11 nodes) Serine proteases, trypsin family, serine active site, and Regulation of eosinophil activation network (Sus scrofa)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	CTRC	Chymotrypsin-C; Belongs to the peptidase S1 family. (268 aa)
	F2RL1	Proteinase-activated receptor 2 preproprotein. (397 aa)
	PRSS2	Putative trypsinogen; Belongs to the peptidase S1 family. (247 aa)
	SYCN	Syncollin. (136 aa)
	CTRL	Chymotrypsin like; Belongs to the peptidase S1 family. (264 aa)
	CPA1	Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. (635 aa)
	LOC100302368	Trypsin. (246 aa)
	LOC110261434	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (270 aa)
	KLK1	Glandular kallikrein; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. (263 aa)
	SPINK1	Serine protease inhibitor Kazal-type 1; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin- catalyzed premature activation of zymogens (By similarity). (79 aa)
	CELA2A	Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. (287 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CELA2A	CPA1	ENSSSCP00000065549	ENSSSCP00000043883	Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily.	Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.	0.905
CELA2A	CTRC	ENSSSCP00000065549	ENSSSCP00000003754	Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily.	Chymotrypsin-C; Belongs to the peptidase S1 family.	0.806
CELA2A	CTRL	ENSSSCP00000065549	ENSSSCP00000021733	Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily.	Chymotrypsin like; Belongs to the peptidase S1 family.	0.461
CELA2A	LOC110261434	ENSSSCP00000065549	ENSSSCP00000054486	Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.996
CPA1	CELA2A	ENSSSCP00000043883	ENSSSCP00000065549	Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.	Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily.	0.905
CPA1	CTRC	ENSSSCP00000043883	ENSSSCP00000003754	Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.	Chymotrypsin-C; Belongs to the peptidase S1 family.	0.992
CPA1	LOC100302368	ENSSSCP00000043883	ENSSSCP00000045861	Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.	Trypsin.	0.500
CPA1	LOC110261434	ENSSSCP00000043883	ENSSSCP00000054486	Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.998
CPA1	SPINK1	ENSSSCP00000043883	ENSSSCP00000058066	Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.	Serine protease inhibitor Kazal-type 1; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin- catalyzed premature activation of zymogens (By similarity).	0.506
CPA1	SYCN	ENSSSCP00000043883	ENSSSCP00000019866	Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.	Syncollin.	0.474
CTRC	CELA2A	ENSSSCP00000003754	ENSSSCP00000065549	Chymotrypsin-C; Belongs to the peptidase S1 family.	Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily.	0.806
CTRC	CPA1	ENSSSCP00000003754	ENSSSCP00000043883	Chymotrypsin-C; Belongs to the peptidase S1 family.	Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.	0.992
CTRC	CTRL	ENSSSCP00000003754	ENSSSCP00000021733	Chymotrypsin-C; Belongs to the peptidase S1 family.	Chymotrypsin like; Belongs to the peptidase S1 family.	0.450
CTRC	LOC100302368	ENSSSCP00000003754	ENSSSCP00000045861	Chymotrypsin-C; Belongs to the peptidase S1 family.	Trypsin.	0.450
CTRC	LOC110261434	ENSSSCP00000003754	ENSSSCP00000054486	Chymotrypsin-C; Belongs to the peptidase S1 family.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.964
CTRC	SPINK1	ENSSSCP00000003754	ENSSSCP00000058066	Chymotrypsin-C; Belongs to the peptidase S1 family.	Serine protease inhibitor Kazal-type 1; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin- catalyzed premature activation of zymogens (By similarity).	0.786
CTRC	SYCN	ENSSSCP00000003754	ENSSSCP00000019866	Chymotrypsin-C; Belongs to the peptidase S1 family.	Syncollin.	0.563
CTRL	CELA2A	ENSSSCP00000021733	ENSSSCP00000065549	Chymotrypsin like; Belongs to the peptidase S1 family.	Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily.	0.461
CTRL	CTRC	ENSSSCP00000021733	ENSSSCP00000003754	Chymotrypsin like; Belongs to the peptidase S1 family.	Chymotrypsin-C; Belongs to the peptidase S1 family.	0.450
CTRL	LOC100302368	ENSSSCP00000021733	ENSSSCP00000045861	Chymotrypsin like; Belongs to the peptidase S1 family.	Trypsin.	0.505