STRINGSTRING
WNT10B WNT10B WNT1 WNT1 PRICKLE4 PRICKLE4 GSK3A GSK3A DVL1 DVL1 WNT4 WNT4 WLS WLS ROR1 ROR1 DAAM1 DAAM1 INVS INVS FZD6 FZD6 WNT8B WNT8B VANGL2 VANGL2 VANGL1 VANGL1 WNT2B WNT2B DKK4 DKK4 RSPO4 RSPO4 SFRP2 SFRP2 OLFM4 OLFM4 ROR2 ROR2 FZD10 FZD10 KREMEN1 KREMEN1 DKK1 DKK1 SFRP5 SFRP5 TCF7L2 TCF7L2 BAMBI BAMBI PRICKLE2 PRICKLE2 LRIG1 LRIG1 RYK RYK PRICKLE3 PRICKLE3 GPC4 GPC4 LRP5 LRP5 LGR4 LGR4 FZD7 FZD7 FZD5 FZD5 WNT16 WNT16 WNT11 WNT11 WNT10A WNT10A DVL2 DVL2 WNT8A WNT8A WNT3A WNT3A DVL3 DVL3 FZD9 FZD9 WNT9A WNT9A TCF7 TCF7 WNT7B WNT7B SFRP1 SFRP1 AMER1 AMER1 WIF1 WIF1 GPC3 GPC3 CTNNB1 CTNNB1 RSPO3 RSPO3 WNT5B WNT5B CER1 CER1 TLE4 TLE4 LEF1 LEF1 FZD3 FZD3 SPATA13 SPATA13 NOTUM NOTUM BCL9 BCL9 APC2 APC2 APC APC WNT5A WNT5A LGR6 LGR6 SFRP4 SFRP4 FRAT1 FRAT1 PORCN PORCN LRP6 LRP6 CTNNBIP1 CTNNBIP1 FZD2 FZD2 WNT7A WNT7A FZD1 FZD1 PRICKLE1 PRICKLE1 FRZB FRZB TLE1 TLE1 DKK2 DKK2 SOST SOST KREMEN2 KREMEN2 GSK3B GSK3B WNT3 WNT3 RSPO1 RSPO1 CCN4 CCN4 NLK NLK WNT2 WNT2 RNF43 RNF43 FRAT2 FRAT2 FZD8 FZD8 ASCL2 ASCL2 AXIN2 AXIN2 LGR5 LGR5 ARHGEF4 ARHGEF4 KLHL12 KLHL12 WNT9B WNT9B MSI1 MSI1 BCL9L BCL9L WNT6 WNT6 CELSR1 CELSR1 FZD4 FZD4 TCF7L1 TCF7L1 ZNRF3 ZNRF3 DAAM2 DAAM2 DKK3 DKK3 TLE2 TLE2 HOPX HOPX AXIN1 AXIN1 RSPO2 RSPO2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
PRICKLE4Uncharacterized protein. (387 aa)
GSK3AProtein kinase domain-containing protein. (566 aa)
DVL1Dishevelled segment polarity protein 1. (700 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
WLSWnt ligand secretion mediator. (545 aa)
ROR1Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (937 aa)
DAAM1Dishevelled associated activator of morphogenesis 1. (1086 aa)
INVSInversin. (1076 aa)
FZD6Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (711 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
VANGL2Vang-like protein. (521 aa)
VANGL1Vang-like protein. (524 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (392 aa)
DKK4Dickkopf WNT signaling pathway inhibitor 4. (223 aa)
RSPO4R-spondin 4. (235 aa)
SFRP2Uncharacterized protein. (294 aa)
OLFM4Olfactomedin 4. (488 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (940 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
KREMEN1Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (464 aa)
DKK1Dickkopf_N domain-containing protein. (357 aa)
SFRP5Uncharacterized protein. (315 aa)
TCF7L2Transcription factor 7 like 2. (669 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
PRICKLE2Prickle planar cell polarity protein 2. (901 aa)
LRIG1Leucine rich repeats and immunoglobulin like domains 1. (1112 aa)
RYKReceptor like tyrosine kinase. (566 aa)
PRICKLE3Prickle planar cell polarity protein 3. (727 aa)
GPC4Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (556 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4 isoform 1. (951 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (586 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (536 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (415 aa)
DVL2Dishevelled segment polarity protein 2. (794 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3 isoform X1. (716 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
TCF7Transcription factor 7. (484 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
AMER1APC membrane recruitment protein 1. (1108 aa)
WIF1Wnt inhibitory factor 1. (379 aa)
GPC3Glypican-3 isoform 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (579 aa)
CTNNB1Catenin beta 1. (808 aa)
RSPO3Uncharacterized protein. (280 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
CER1Cerberus 1, DAN family BMP antagonist. (273 aa)
TLE4TLE family member 4, transcriptional corepressor. (774 aa)
LEF1Lymphoid enhancer binding factor 1. (429 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
SPATA13Uncharacterized protein. (1159 aa)
NOTUMNotum, palmitoleoyl-protein carboxylesterase. (570 aa)
BCL9B-cell CLL/lymphoma 9 protein; Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). (1435 aa)
APC2Uncharacterized protein. (2292 aa)
APCAPC_basic domain-containing protein. (2713 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
LGR6Leucine rich repeat containing G protein-coupled receptor 6. (967 aa)
SFRP4Secreted frizzled-related protein 4. (346 aa)
FRAT1Uncharacterized protein. (279 aa)
PORCNProtein-serine O-palmitoleoyltransferase porcupine isoform D; Belongs to the membrane-bound acyltransferase family. (461 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1612 aa)
CTNNBIP1Beta-catenin-interacting protein 1. (81 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (558 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (564 aa)
PRICKLE1Prickle planar cell polarity protein 1. (856 aa)
FRZBSecreted frizzled-related protein 3. (325 aa)
TLE1TLE family member 1, transcriptional corepressor. (770 aa)
DKK2Dickkopf WNT signaling pathway inhibitor 2. (259 aa)
SOSTSclerostin. (212 aa)
KREMEN2Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (461 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (414 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (453 aa)
RSPO1R-spondin 1. (262 aa)
CCN4WNT1-inducible-signaling pathway protein 1 isoform X1. (371 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
RNF43RING-type domain-containing protein. (743 aa)
FRAT2FRAT regulator of WNT signaling pathway 2. (228 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (560 aa)
ASCL2BHLH domain-containing protein. (193 aa)
AXIN2Axin-2. (843 aa)
LGR5Leucine-rich repeat-containing G-protein coupled receptor 5 isoform 1. (907 aa)
ARHGEF4Rho guanine nucleotide exchange factor 4. (748 aa)
KLHL12BTB domain-containing protein. (916 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
MSI1Musashi RNA binding protein 1. (436 aa)
BCL9LBCL9 like. (1526 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (364 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (3320 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (536 aa)
TCF7L1HMG box domain-containing protein. (412 aa)
ZNRF3Zinc and ring finger 3. (912 aa)
DAAM2Dishevelled associated activator of morphogenesis 2. (1075 aa)
DKK3Dickkopf WNT signaling pathway inhibitor 3. (433 aa)
TLE2TLE family member 2, transcriptional corepressor. (750 aa)
HOPXHomeodomain-only protein; Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF- dependent cardiac-specific genes and cardiac development. Prevents SRF- dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein ref [...] (285 aa)
AXIN1Axin 1. (867 aa)
RSPO2Uncharacterized protein. (242 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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