(26 nodes) Wnt signaling pathway network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
	FZD6	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (711 aa)
	WNT8B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (392 aa)
	SFRP2	Uncharacterized protein. (294 aa)
	ROR2	Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (940 aa)
	SFRP5	Uncharacterized protein. (315 aa)
	RYK	Receptor like tyrosine kinase. (566 aa)
	FZD5	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (586 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (536 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	SFRP1	Secreted frizzled-related protein 1. (308 aa)
	WIF1	Wnt inhibitory factor 1. (379 aa)
	WNT5B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	SFRP4	Secreted frizzled-related protein 4. (346 aa)
	PORCN	Protein-serine O-palmitoleoyltransferase porcupine isoform D; Belongs to the membrane-bound acyltransferase family. (461 aa)
	FZD2	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (558 aa)
	FZD1	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (564 aa)
	WNT3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (453 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
	FZD4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (536 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FZD1	FZD2	ENSSSCP00000043267	ENSSSCP00000042537	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	0.512
FZD1	PORCN	ENSSSCP00000043267	ENSSSCP00000039178	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein-serine O-palmitoleoyltransferase porcupine isoform D; Belongs to the membrane-bound acyltransferase family.	0.463
FZD1	ROR2	ENSSSCP00000043267	ENSSSCP00000010242	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.	0.923
FZD1	RYK	ENSSSCP00000043267	ENSSSCP00000012409	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Receptor like tyrosine kinase.	0.941
FZD1	SFRP1	ENSSSCP00000043267	ENSSSCP00000029500	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled-related protein 1.	0.723
FZD1	SFRP2	ENSSSCP00000043267	ENSSSCP00000009608	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein.	0.704
FZD1	SFRP4	ENSSSCP00000043267	ENSSSCP00000038384	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled-related protein 4.	0.670
FZD1	SFRP5	ENSSSCP00000043267	ENSSSCP00000011218	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein.	0.702
FZD1	WIF1	ENSSSCP00000043267	ENSSSCP00000029993	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Wnt inhibitory factor 1.	0.466
FZD1	WNT1	ENSSSCP00000043267	ENSSSCP00000000190	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.978
FZD1	WNT11	ENSSSCP00000043267	ENSSSCP00000019221	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.963
FZD1	WNT16	ENSSSCP00000043267	ENSSSCP00000017601	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.789
FZD1	WNT2	ENSSSCP00000043267	ENSSSCP00000051493	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.899
FZD1	WNT2B	ENSSSCP00000043267	ENSSSCP00000007231	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.883
FZD1	WNT3	ENSSSCP00000043267	ENSSSCP00000046724	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.856
FZD1	WNT3A	ENSSSCP00000043267	ENSSSCP00000021525	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.958
FZD1	WNT4	ENSSSCP00000043267	ENSSSCP00000003822	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.871
FZD1	WNT5A	ENSSSCP00000043267	ENSSSCP00000037791	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.980
FZD1	WNT5B	ENSSSCP00000043267	ENSSSCP00000033360	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.965
FZD1	WNT8B	ENSSSCP00000043267	ENSSSCP00000006575	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.826