(23 nodes) beta-catenin-TCF complex, and Beta-catenin destruction complex network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GSK3A	Protein kinase domain-containing protein. (566 aa)
	TCF7L2	Transcription factor 7 like 2. (669 aa)
	TCF7	Transcription factor 7. (484 aa)
	AMER1	APC membrane recruitment protein 1. (1108 aa)
	CTNNB1	Catenin beta 1. (808 aa)
	TLE4	TLE family member 4, transcriptional corepressor. (774 aa)
	LEF1	Lymphoid enhancer binding factor 1. (429 aa)
	SPATA13	Uncharacterized protein. (1159 aa)
	BCL9	B-cell CLL/lymphoma 9 protein; Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). (1435 aa)
	APC2	Uncharacterized protein. (2292 aa)
	APC	APC_basic domain-containing protein. (2713 aa)
	FRAT1	Uncharacterized protein. (279 aa)
	CTNNBIP1	Beta-catenin-interacting protein 1. (81 aa)
	TLE1	TLE family member 1, transcriptional corepressor. (770 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (414 aa)
	NLK	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
	FRAT2	FRAT regulator of WNT signaling pathway 2. (228 aa)
	AXIN2	Axin-2. (843 aa)
	ARHGEF4	Rho guanine nucleotide exchange factor 4. (748 aa)
	BCL9L	BCL9 like. (1526 aa)
	TCF7L1	HMG box domain-containing protein. (412 aa)
	TLE2	TLE family member 2, transcriptional corepressor. (750 aa)
	AXIN1	Axin 1. (867 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMER1	APC	ENSSSCP00000029629	ENSSSCP00000037698	APC membrane recruitment protein 1.	APC_basic domain-containing protein.	0.971
AMER1	APC2	ENSSSCP00000029629	ENSSSCP00000037191	APC membrane recruitment protein 1.	Uncharacterized protein.	0.651
AMER1	AXIN1	ENSSSCP00000029629	ENSSSCP00000072335	APC membrane recruitment protein 1.	Axin 1.	0.946
AMER1	AXIN2	ENSSSCP00000029629	ENSSSCP00000054961	APC membrane recruitment protein 1.	Axin-2.	0.502
AMER1	CTNNB1	ENSSSCP00000029629	ENSSSCP00000031836	APC membrane recruitment protein 1.	Catenin beta 1.	0.932
AMER1	FRAT1	ENSSSCP00000029629	ENSSSCP00000038733	APC membrane recruitment protein 1.	Uncharacterized protein.	0.400
AMER1	FRAT2	ENSSSCP00000029629	ENSSSCP00000053206	APC membrane recruitment protein 1.	FRAT regulator of WNT signaling pathway 2.	0.400
AMER1	GSK3B	ENSSSCP00000029629	ENSSSCP00000046229	APC membrane recruitment protein 1.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.850
APC	AMER1	ENSSSCP00000037698	ENSSSCP00000029629	APC_basic domain-containing protein.	APC membrane recruitment protein 1.	0.971
APC	APC2	ENSSSCP00000037698	ENSSSCP00000037191	APC_basic domain-containing protein.	Uncharacterized protein.	0.905
APC	ARHGEF4	ENSSSCP00000037698	ENSSSCP00000055644	APC_basic domain-containing protein.	Rho guanine nucleotide exchange factor 4.	0.988
APC	AXIN1	ENSSSCP00000037698	ENSSSCP00000072335	APC_basic domain-containing protein.	Axin 1.	0.996
APC	AXIN2	ENSSSCP00000037698	ENSSSCP00000054961	APC_basic domain-containing protein.	Axin-2.	0.977
APC	CTNNB1	ENSSSCP00000037698	ENSSSCP00000031836	APC_basic domain-containing protein.	Catenin beta 1.	0.997
APC	CTNNBIP1	ENSSSCP00000037698	ENSSSCP00000041866	APC_basic domain-containing protein.	Beta-catenin-interacting protein 1.	0.717
APC	FRAT1	ENSSSCP00000037698	ENSSSCP00000038733	APC_basic domain-containing protein.	Uncharacterized protein.	0.465
APC	FRAT2	ENSSSCP00000037698	ENSSSCP00000053206	APC_basic domain-containing protein.	FRAT regulator of WNT signaling pathway 2.	0.465
APC	GSK3A	ENSSSCP00000037698	ENSSSCP00000003288	APC_basic domain-containing protein.	Protein kinase domain-containing protein.	0.628
APC	GSK3B	ENSSSCP00000037698	ENSSSCP00000046229	APC_basic domain-containing protein.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.994
APC	LEF1	ENSSSCP00000037698	ENSSSCP00000033976	APC_basic domain-containing protein.	Lymphoid enhancer binding factor 1.	0.918