(14 nodes) Regulation of FZD by ubiquitination, and Bone regeneration network (Sus scrofa)

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Your Input:
	RSPO4	R-spondin 4. (235 aa)
	OLFM4	Olfactomedin 4. (488 aa)
	LRIG1	Leucine rich repeats and immunoglobulin like domains 1. (1112 aa)
	LGR4	Leucine-rich repeat-containing G-protein coupled receptor 4 isoform 1. (951 aa)
	RSPO3	Uncharacterized protein. (280 aa)
	LGR6	Leucine rich repeat containing G protein-coupled receptor 6. (967 aa)
	RSPO1	R-spondin 1. (262 aa)
	RNF43	RING-type domain-containing protein. (743 aa)
	ASCL2	BHLH domain-containing protein. (193 aa)
	LGR5	Leucine-rich repeat-containing G-protein coupled receptor 5 isoform 1. (907 aa)
	MSI1	Musashi RNA binding protein 1. (436 aa)
	ZNRF3	Zinc and ring finger 3. (912 aa)
	HOPX	Homeodomain-only protein; Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF- dependent cardiac-specific genes and cardiac development. Prevents SRF- dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein ref [...] (285 aa)
	RSPO2	Uncharacterized protein. (242 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASCL2	HOPX	ENSSSCP00000054800	ENSSSCP00000071022	BHLH domain-containing protein.	Homeodomain-only protein; Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF- dependent cardiac-specific genes and cardiac development. Prevents SRF- dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein ref [...]	0.589
ASCL2	LGR5	ENSSSCP00000054800	ENSSSCP00000055379	BHLH domain-containing protein.	Leucine-rich repeat-containing G-protein coupled receptor 5 isoform 1.	0.913
ASCL2	LRIG1	ENSSSCP00000054800	ENSSSCP00000012255	BHLH domain-containing protein.	Leucine rich repeats and immunoglobulin like domains 1.	0.829
ASCL2	MSI1	ENSSSCP00000054800	ENSSSCP00000058377	BHLH domain-containing protein.	Musashi RNA binding protein 1.	0.542
ASCL2	OLFM4	ENSSSCP00000054800	ENSSSCP00000010084	BHLH domain-containing protein.	Olfactomedin 4.	0.901
ASCL2	RSPO1	ENSSSCP00000054800	ENSSSCP00000047627	BHLH domain-containing protein.	R-spondin 1.	0.405
HOPX	ASCL2	ENSSSCP00000071022	ENSSSCP00000054800	Homeodomain-only protein; Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF- dependent cardiac-specific genes and cardiac development. Prevents SRF- dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein ref [...]	BHLH domain-containing protein.	0.589
HOPX	LGR5	ENSSSCP00000071022	ENSSSCP00000055379	Homeodomain-only protein; Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF- dependent cardiac-specific genes and cardiac development. Prevents SRF- dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein ref [...]	Leucine-rich repeat-containing G-protein coupled receptor 5 isoform 1.	0.702
HOPX	LRIG1	ENSSSCP00000071022	ENSSSCP00000012255	Homeodomain-only protein; Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF- dependent cardiac-specific genes and cardiac development. Prevents SRF- dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein ref [...]	Leucine rich repeats and immunoglobulin like domains 1.	0.692
HOPX	OLFM4	ENSSSCP00000071022	ENSSSCP00000010084	Homeodomain-only protein; Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF- dependent cardiac-specific genes and cardiac development. Prevents SRF- dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein ref [...]	Olfactomedin 4.	0.627
LGR4	LGR5	ENSSSCP00000014168	ENSSSCP00000055379	Leucine-rich repeat-containing G-protein coupled receptor 4 isoform 1.	Leucine-rich repeat-containing G-protein coupled receptor 5 isoform 1.	0.919
LGR4	LGR6	ENSSSCP00000014168	ENSSSCP00000037944	Leucine-rich repeat-containing G-protein coupled receptor 4 isoform 1.	Leucine rich repeat containing G protein-coupled receptor 6.	0.930
LGR4	RNF43	ENSSSCP00000014168	ENSSSCP00000051795	Leucine-rich repeat-containing G-protein coupled receptor 4 isoform 1.	RING-type domain-containing protein.	0.960
LGR4	RSPO1	ENSSSCP00000014168	ENSSSCP00000047627	Leucine-rich repeat-containing G-protein coupled receptor 4 isoform 1.	R-spondin 1.	0.993
LGR4	RSPO2	ENSSSCP00000014168	ENSSSCP00000072348	Leucine-rich repeat-containing G-protein coupled receptor 4 isoform 1.	Uncharacterized protein.	0.995
LGR4	RSPO3	ENSSSCP00000014168	ENSSSCP00000031989	Leucine-rich repeat-containing G-protein coupled receptor 4 isoform 1.	Uncharacterized protein.	0.975
LGR4	RSPO4	ENSSSCP00000014168	ENSSSCP00000007665	Leucine-rich repeat-containing G-protein coupled receptor 4 isoform 1.	R-spondin 4.	0.970
LGR4	ZNRF3	ENSSSCP00000014168	ENSSSCP00000063657	Leucine-rich repeat-containing G-protein coupled receptor 4 isoform 1.	Zinc and ring finger 3.	0.760
LGR5	ASCL2	ENSSSCP00000055379	ENSSSCP00000054800	Leucine-rich repeat-containing G-protein coupled receptor 5 isoform 1.	BHLH domain-containing protein.	0.913
LGR5	HOPX	ENSSSCP00000055379	ENSSSCP00000071022	Leucine-rich repeat-containing G-protein coupled receptor 5 isoform 1.	Homeodomain-only protein; Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF- dependent cardiac-specific genes and cardiac development. Prevents SRF- dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein ref [...]	0.702