STRINGSTRING
PPARA PPARA NAB2 NAB2 CD69 CD69 RXRB RXRB PML PML EGLN3 EGLN3 CEBPE CEBPE ADGRG3 ADGRG3 CEBPA CEBPA HIF3A HIF3A ATF5 ATF5 NR1H2 NR1H2 TLE3 TLE3 ESR2 ESR2 RUNX1T1 RUNX1T1 CRABP2 CRABP2 ARNT ARNT CIART CIART NCOA3 NCOA3 MAFK MAFK NPAS2 NPAS2 EPAS1 EPAS1 NFIL3 NFIL3 NCOR2 NCOR2 EGLN1 EGLN1 EGR2 EGR2 LDB1 LDB1 CREM CREM GATA2 GATA2 BCL6 BCL6 NPAS4 NPAS4 NR1H3 NR1H3 CRY2 CRY2 LMO2 LMO2 KLF1 KLF1 FBXL17 FBXL17 IRF1 IRF1 EGR1 EGR1 PGR PGR ATF3 ATF3 ETV4 ETV4 TBX21 TBX21 GPS2 GPS2 F1SDC8_PIG F1SDC8_PIG BATF3 BATF3 EP300 EP300 NFE2L3 NFE2L3 GATA1 GATA1 SMCO2 SMCO2 KMT2E KMT2E JUNB JUNB MAFF MAFF NR1D2 NR1D2 KAT2B KAT2B PER3 PER3 BATF2 BATF2 FLT3 FLT3 PER1 PER1 EIF2AK3 EIF2AK3 SRC SRC ESR1 ESR1 DUSP1 DUSP1 TBL1X TBL1X MSMP MSMP MAF MAF FOSL2 FOSL2 ARNTL2 ARNTL2 ARNT2 ARNT2 RARG RARG CRY1 CRY1 ARX ARX BACH2 BACH2 TEF TEF LOC100624648 LOC100624648 NFE2 NFE2 RARA RARA EGR4 EGR4 NR1D1 NR1D1 LMO1 LMO1 RORC RORC TAL1 TAL1 SP1 SP1 LOC100523244 LOC100523244 NR4A2 NR4A2 A0A287A514_PIG A0A287A514_PIG CLOCK CLOCK PAX5 PAX5 IRF4 IRF4 SPIB SPIB GATA3 GATA3 CIPC CIPC RUNX1 RUNX1 CEBPG CEBPG FOXA1 FOXA1 NCOA2 NCOA2 DDIT3 DDIT3 TBL1XR1 TBL1XR1 NR4A1 NR4A1 CEBPB CEBPB IRF8 IRF8 ZNF217 ZNF217 NCOA1 NCOA1 XBP1 XBP1 BHLHE41 BHLHE41 ZFPM1 ZFPM1 FOXP3 FOXP3 NAB1 NAB1 TCF12 TCF12 HIF1A HIF1A CEBPD CEBPD ARNTL ARNTL HDAC3 HDAC3 MAFG MAFG KLF15 KLF15 EGR3 EGR3 NR5A2 NR5A2 MYSM1 MYSM1 LOC106509183 LOC106509183 FOSL1 FOSL1 BACH1 BACH1 RXRG RXRG PRDM1 PRDM1 ATF4 ATF4 NR4A3 NR4A3 TRIB3 TRIB3 THRB THRB PER2 PER2 BHLHE40 BHLHE40 FOSB FOSB ATF6 ATF6 NRIP1 NRIP1 A0A5G2QED1_PIG A0A5G2QED1_PIG ETS1 ETS1 RAG1 RAG1 FHL5 FHL5 NFE2L2 NFE2L2 RUNX3 RUNX3 EGLN2 EGLN2 A0A5G2RAG6_PIG A0A5G2RAG6_PIG RAG2 RAG2 AICDA AICDA CARM1 CARM1 EGLN2-2 EGLN2-2 LINC01862 LINC01862 RXRA RXRA FOS FOS THRA THRA CBFB CBFB MAPK13 MAPK13 CSNK1D CSNK1D SPI1 SPI1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPARAUncharacterized protein. (469 aa)
NAB2NGFI-A binding protein 2. (525 aa)
CD69C-type lectin domain-containing protein. (200 aa)
RXRBRetinoid X receptor beta. (536 aa)
PMLPromyelocytic leukemia. (827 aa)
EGLN3Egl-9 family hypoxia inducible factor 3. (239 aa)
CEBPECCAAT/enhancer-binding protein. (282 aa)
ADGRG3Adhesion G protein-coupled receptor G3; Belongs to the G-protein coupled receptor 2 family. (550 aa)
CEBPACCAAT/enhancer-binding protein alpha isoform c. (354 aa)
HIF3AHypoxia inducible factor 3 subunit alpha. (671 aa)
ATF5Activating transcription factor 5. (282 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (458 aa)
TLE3TLE family member 3, transcriptional corepressor. (808 aa)
ESR2Estrogen receptor beta; Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1 (ER-alpha), and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. May play a role in ovarian follicular growth and maturation. (526 aa)
RUNX1T1RUNX1 partner transcriptional co-repressor 1. (604 aa)
CRABP2FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (138 aa)
ARNTAryl hydrocarbon receptor nuclear translocator isoform X3. (790 aa)
CIARTCircadian-associated transcriptional repressor isoform a. (453 aa)
NCOA3Uncharacterized protein. (1296 aa)
MAFKMAF bZIP transcription factor K. (156 aa)
NPAS2Neuronal PAS domain protein 2. (796 aa)
EPAS1Uncharacterized protein. (870 aa)
NFIL3Nuclear factor interleukin-3-regulated protein; Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T- cells. Competes for the same consensus-binding site with PAR DNA- bi [...] (462 aa)
NCOR2Uncharacterized protein. (2450 aa)
EGLN1Uncharacterized protein. (427 aa)
EGR2E3 SUMO-protein ligase EGR2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. Binds to the promoter region of ERBB2 (By similarity); Belongs to the EGR C2H2-type zinc-finger protein family. (471 aa)
LDB1LID domain-containing protein. (411 aa)
CREMcAMP responsive element modulator. (360 aa)
GATA2GATA binding protein 2. (502 aa)
BCL6B-cell lymphoma 6 protein isoform X1. (706 aa)
NPAS4Neuronal PAS domain protein 4. (803 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (470 aa)
CRY2Cryptochrome circadian regulator 2. (615 aa)
LMO2LIM domain only 2. (223 aa)
KLF1Kruppel-like factor 1. (367 aa)
FBXL17F-box and leucine rich repeat protein 17. (700 aa)
IRF1Interferon regulatory factor 1; Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target [...] (320 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
PGRProgesterone receptor isoform B. (934 aa)
ATF3Cyclic AMP-dependent transcription factor ATF-3 isoform X1. (250 aa)
ETV4ETS variant 4. (485 aa)
TBX21Uncharacterized protein. (535 aa)
GPS2G protein pathway suppressor 2. (327 aa)
F1SDC8_PIGUncharacterized protein. (1369 aa)
BATF3Basic leucine zipper transcriptional factor ATF-like 3. (122 aa)
EP300E1A binding protein p300. (2420 aa)
NFE2L3Nuclear factor, erythroid 2 like 3. (686 aa)
GATA1Erythroid transcription factor. (412 aa)
SMCO2Single-pass membrane protein with coiled-coil domains 2. (369 aa)
KMT2EMyeloid/lymphoid or mixed-lineage leukemia 5. (1859 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
MAFFMAF bZIP transcription factor F. (166 aa)
NR1D2Uncharacterized protein. (609 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (831 aa)
PER3PAS domain-containing protein. (376 aa)
BATF2Basic leucine zipper transcriptional factor ATF-like 2 isoform 1. (276 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (990 aa)
PER1Period circadian regulator 1. (1278 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1095 aa)
SRCTyrosine-protein kinase. (559 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (353 aa)
TBL1XUncharacterized protein. (615 aa)
MSMPBeta-microseminoprotein. (156 aa)
MAFMAF bZIP transcription factor; Belongs to the bZIP family. (408 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (327 aa)
ARNTL2Aryl hydrocarbon receptor nuclear translocator like 2. (652 aa)
ARNT2Aryl hydrocarbon receptor nuclear translocator 2. (892 aa)
RARGRetinoic acid receptor gamma. (554 aa)
CRY1Cryptochrome circadian regulator 1. (588 aa)
ARXAristaless related homeobox. (563 aa)
BACH2Transcription regulator protein BACH2 isoform X2. (843 aa)
TEFTEF transcription factor, PAR bZIP family member. (302 aa)
LOC100624648F-box-like/WD repeat-containing protein TBL1X isoform a. (529 aa)
NFE2Nuclear factor, erythroid 2. (373 aa)
RARARetinoic acid receptor alpha isoform X1. (462 aa)
EGR4Uncharacterized protein. (590 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1 isoform X2. (616 aa)
LMO1LIM domain only 1. (214 aa)
RORCRAR related orphan receptor C. (518 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (331 aa)
SP1Transcription factor Sp1 isoform a. (786 aa)
LOC100523244Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (454 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2 isoform X1. (609 aa)
A0A287A514_PIGNR LBD domain-containing protein. (88 aa)
CLOCKClock circadian regulator. (857 aa)
PAX5Paired box 5. (390 aa)
IRF4Interferon regulatory factor 4. (451 aa)
SPIBETS domain-containing protein. (263 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3. (444 aa)
CIPCCLOCK interacting pacemaker. (378 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
CEBPGCCAAT enhancer binding protein gamma. (164 aa)
FOXA1Forkhead box A1. (468 aa)
NCOA2Nuclear receptor coactivator. (1463 aa)
DDIT3DNA-damage-inducible transcript 3. (167 aa)
TBL1XR1Transducin beta like 1 X-linked receptor 1. (526 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1 isoform 2. (598 aa)
CEBPBCCAAT/enhancer-binding protein. (346 aa)
IRF8Interferon regulatory factor 8. (426 aa)
ZNF217Zinc finger protein 217. (1046 aa)
NCOA1Nuclear receptor coactivator 1; Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone- dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating m [...] (1441 aa)
XBP1BZIP domain-containing protein. (378 aa)
BHLHE41Class E basic helix-loop-helix protein 41. (482 aa)
ZFPM1Zinc finger protein, FOG family member 1. (965 aa)
FOXP3Forkhead box protein P3 isoform a. (475 aa)
NAB1NGFI-A-binding protein 1 isoform X1. (522 aa)
TCF12Transcription factor 12 isoform a. (706 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform 1. (824 aa)
CEBPDCCAAT enhancer binding protein delta. (253 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (633 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (520 aa)
MAFGMAF bZIP transcription factor G. (162 aa)
KLF15Kruppel like factor 15. (450 aa)
EGR3Early growth response protein 3 isoform 1. (387 aa)
NR5A2Nuclear receptor subfamily 5 group A member 2. (541 aa)
MYSM1Myb like, SWIRM and MPN domains 1. (807 aa)
LOC106509183Histone-arginine methyltransferase CARM1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (499 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
BACH1Transcription regulator protein BACH1. (742 aa)
RXRGRetinoic acid receptor RXR-gamma; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity). (463 aa)
PRDM1PR/SET domain 1. (842 aa)
ATF4Activating transcription factor 4. (329 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3 isoform b. (643 aa)
TRIB3Tribbles pseudokinase 3. (373 aa)
THRBThyroid hormone receptor beta isoform X2. (476 aa)
PER2Period circadian regulator 2. (1362 aa)
BHLHE40Basic helix-loop-helix family member e40. (415 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (337 aa)
ATF6Activating transcription factor 6. (680 aa)
NRIP1Nuclear receptor-interacting protein 1 isoform X1. (1156 aa)
A0A5G2QED1_PIGPeriod_C domain-containing protein. (481 aa)
ETS1ETS proto-oncogene 1, transcription factor. (621 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1049 aa)
FHL5Four and a half LIM domains 5. (285 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (656 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (437 aa)
EGLN2Uncharacterized protein. (257 aa)
A0A5G2RAG6_PIGUncharacterized protein. (876 aa)
RAG2V(D)J recombination activating protein 2. (527 aa)
AICDAActivation induced cytidine deaminase. (224 aa)
CARM1Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (643 aa)
EGLN2-2Fe2OG dioxygenase domain-containing protein. (125 aa)
LINC01862Long intergenic non-protein coding RNA 1862. (286 aa)
RXRARetinoid X receptor alpha. (701 aa)
FOSProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (440 aa)
THRAThyroid hormone receptor alpha; Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. (508 aa)
CBFBCore-binding factor subunit beta. (204 aa)
MAPK13Mitogen-activated protein kinase. (435 aa)
CSNK1DCasein kinase 1 delta. (459 aa)
SPI1Transcription factor PU.1; Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA- 3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity). (277 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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