(14 nodes) Mixed, incl. NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis, and Thyroid hormone receptor network (Sus scrofa)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PPARA	Uncharacterized protein. (469 aa)
	RXRB	Retinoid X receptor beta. (536 aa)
	NR1H2	Nuclear receptor subfamily 1 group H member 2. (458 aa)
	CRABP2	FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (138 aa)
	NR1H3	Nuclear receptor subfamily 1 group H member 3. (470 aa)
	EP300	E1A binding protein p300. (2420 aa)
	KAT2B	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (831 aa)
	RARG	Retinoic acid receptor gamma. (554 aa)
	NCOA2	Nuclear receptor coactivator. (1463 aa)
	MYSM1	Myb like, SWIRM and MPN domains 1. (807 aa)
	RXRG	Retinoic acid receptor RXR-gamma; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity). (463 aa)
	THRB	Thyroid hormone receptor beta isoform X2. (476 aa)
	RXRA	Retinoid X receptor alpha. (701 aa)
	THRA	Thyroid hormone receptor alpha; Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. (508 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRABP2	RARG	ENSSSCP00000006897	ENSSSCP00000032642	FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	Retinoic acid receptor gamma.	0.702
CRABP2	RXRA	ENSSSCP00000006897	ENSSSCP00000070850	FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	Retinoid X receptor alpha.	0.616
CRABP2	RXRG	ENSSSCP00000006897	ENSSSCP00000057363	FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	Retinoic acid receptor RXR-gamma; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).	0.658
EP300	KAT2B	ENSSSCP00000020812	ENSSSCP00000026852	E1A binding protein p300.	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily.	0.979
EP300	MYSM1	ENSSSCP00000020812	ENSSSCP00000055457	E1A binding protein p300.	Myb like, SWIRM and MPN domains 1.	0.831
EP300	NCOA2	ENSSSCP00000020812	ENSSSCP00000042311	E1A binding protein p300.	Nuclear receptor coactivator.	0.952
EP300	NR1H2	ENSSSCP00000020812	ENSSSCP00000003483	E1A binding protein p300.	Nuclear receptor subfamily 1 group H member 2.	0.600
EP300	NR1H3	ENSSSCP00000020812	ENSSSCP00000014069	E1A binding protein p300.	Nuclear receptor subfamily 1 group H member 3.	0.671
EP300	PPARA	ENSSSCP00000020812	ENSSSCP00000000007	E1A binding protein p300.	Uncharacterized protein.	0.750
EP300	RXRA	ENSSSCP00000020812	ENSSSCP00000070850	E1A binding protein p300.	Retinoid X receptor alpha.	0.773
EP300	RXRB	ENSSSCP00000020812	ENSSSCP00000001600	E1A binding protein p300.	Retinoid X receptor beta.	0.761
EP300	RXRG	ENSSSCP00000020812	ENSSSCP00000057363	E1A binding protein p300.	Retinoic acid receptor RXR-gamma; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).	0.768
EP300	THRA	ENSSSCP00000020812	ENSSSCP00000071017	E1A binding protein p300.	Thyroid hormone receptor alpha; Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.	0.710
EP300	THRB	ENSSSCP00000020812	ENSSSCP00000058440	E1A binding protein p300.	Thyroid hormone receptor beta isoform X2.	0.710
KAT2B	EP300	ENSSSCP00000026852	ENSSSCP00000020812	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily.	E1A binding protein p300.	0.979
KAT2B	MYSM1	ENSSSCP00000026852	ENSSSCP00000055457	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily.	Myb like, SWIRM and MPN domains 1.	0.947
KAT2B	NCOA2	ENSSSCP00000026852	ENSSSCP00000042311	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily.	Nuclear receptor coactivator.	0.884
KAT2B	RXRA	ENSSSCP00000026852	ENSSSCP00000070850	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily.	Retinoid X receptor alpha.	0.672
KAT2B	RXRB	ENSSSCP00000026852	ENSSSCP00000001600	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily.	Retinoid X receptor beta.	0.672
KAT2B	RXRG	ENSSSCP00000026852	ENSSSCP00000057363	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily.	Retinoic acid receptor RXR-gamma; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).	0.672