node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHGA | CHGB | ENSSSCP00000072459 | ENSSSCP00000034002 | p-Glu serpinin precursor; [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Can induce mast cell migration, degranulation and production of cytokines and chemokines. Belongs to the chromogranin/secretogranin protein family. | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. | 0.957 |
CHGA | PCSK2 | ENSSSCP00000072459 | ENSSSCP00000007546 | p-Glu serpinin precursor; [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Can induce mast cell migration, degranulation and production of cytokines and chemokines. Belongs to the chromogranin/secretogranin protein family. | Neuroendocrine convertase 2; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells (By similarity). | 0.510 |
CHGA | SCG2 | ENSSSCP00000072459 | ENSSSCP00000040210 | p-Glu serpinin precursor; [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Can induce mast cell migration, degranulation and production of cytokines and chemokines. Belongs to the chromogranin/secretogranin protein family. | Secretogranin-2; Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules. | 0.782 |
CHGA | SCG3 | ENSSSCP00000072459 | ENSSSCP00000044507 | p-Glu serpinin precursor; [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Can induce mast cell migration, degranulation and production of cytokines and chemokines. Belongs to the chromogranin/secretogranin protein family. | Secretogranin III. | 0.623 |
CHGA | SCG5 | ENSSSCP00000072459 | ENSSSCP00000005176 | p-Glu serpinin precursor; [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Can induce mast cell migration, degranulation and production of cytokines and chemokines. Belongs to the chromogranin/secretogranin protein family. | Neuroendocrine protein 7B2; Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. | 0.408 |
CHGB | CHGA | ENSSSCP00000034002 | ENSSSCP00000072459 | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. | p-Glu serpinin precursor; [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Can induce mast cell migration, degranulation and production of cytokines and chemokines. Belongs to the chromogranin/secretogranin protein family. | 0.957 |
CHGB | PCSK2 | ENSSSCP00000034002 | ENSSSCP00000007546 | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. | Neuroendocrine convertase 2; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells (By similarity). | 0.593 |
CHGB | SCG2 | ENSSSCP00000034002 | ENSSSCP00000040210 | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. | Secretogranin-2; Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules. | 0.919 |
CHGB | SCG3 | ENSSSCP00000034002 | ENSSSCP00000044507 | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. | Secretogranin III. | 0.766 |
CHGB | SCG5 | ENSSSCP00000034002 | ENSSSCP00000005176 | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. | Neuroendocrine protein 7B2; Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. | 0.730 |
PCSK2 | CHGA | ENSSSCP00000007546 | ENSSSCP00000072459 | Neuroendocrine convertase 2; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells (By similarity). | p-Glu serpinin precursor; [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Can induce mast cell migration, degranulation and production of cytokines and chemokines. Belongs to the chromogranin/secretogranin protein family. | 0.510 |
PCSK2 | CHGB | ENSSSCP00000007546 | ENSSSCP00000034002 | Neuroendocrine convertase 2; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells (By similarity). | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. | 0.593 |
PCSK2 | SCG2 | ENSSSCP00000007546 | ENSSSCP00000040210 | Neuroendocrine convertase 2; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells (By similarity). | Secretogranin-2; Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules. | 0.455 |
PCSK2 | SCG5 | ENSSSCP00000007546 | ENSSSCP00000005176 | Neuroendocrine convertase 2; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells (By similarity). | Neuroendocrine protein 7B2; Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. | 0.816 |
SCG2 | CHGA | ENSSSCP00000040210 | ENSSSCP00000072459 | Secretogranin-2; Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules. | p-Glu serpinin precursor; [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Can induce mast cell migration, degranulation and production of cytokines and chemokines. Belongs to the chromogranin/secretogranin protein family. | 0.782 |
SCG2 | CHGB | ENSSSCP00000040210 | ENSSSCP00000034002 | Secretogranin-2; Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules. | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. | 0.919 |
SCG2 | PCSK2 | ENSSSCP00000040210 | ENSSSCP00000007546 | Secretogranin-2; Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules. | Neuroendocrine convertase 2; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells (By similarity). | 0.455 |
SCG2 | SCG3 | ENSSSCP00000040210 | ENSSSCP00000044507 | Secretogranin-2; Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules. | Secretogranin III. | 0.719 |
SCG2 | SCG5 | ENSSSCP00000040210 | ENSSSCP00000005176 | Secretogranin-2; Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules. | Neuroendocrine protein 7B2; Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. | 0.735 |
SCG3 | CHGA | ENSSSCP00000044507 | ENSSSCP00000072459 | Secretogranin III. | p-Glu serpinin precursor; [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Can induce mast cell migration, degranulation and production of cytokines and chemokines. Belongs to the chromogranin/secretogranin protein family. | 0.623 |