STRINGSTRING
PPP1R3G PPP1R3G PPP1R11 PPP1R11 PPP1R3E PPP1R3E PPP1R15A PPP1R15A PPP1R3D PPP1R3D PHKG1 PHKG1 PHKG2 PHKG2 LRRC43 LRRC43 PPP1R3C PPP1R3C PHKA1 PHKA1 PPP1R7 PPP1R7 PPP1R3A PPP1R3A F1SFT7_PIG F1SFT7_PIG PPP1R10 PPP1R10 PPP1CA PPP1CA PPP1R14A PPP1R14A PHKB PHKB PPP1CB PPP1CB PHKA2 PHKA2 PPP1R12B PPP1R12B ROCK2 ROCK2 PPP1CC PPP1CC ROCK1 ROCK1 PPP1R12C PPP1R12C PPP1R12A PPP1R12A PPP1R3F PPP1R3F PPP1R3B PPP1R3B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPP1R3GProtein phosphatase 1 regulatory subunit 3G. (353 aa)
PPP1R11Protein phosphatase 1 regulatory inhibitor subunit 11. (126 aa)
PPP1R3EProtein phosphatase 1 regulatory subunit 3E. (279 aa)
PPP1R15AProtein phosphatase 1 regulatory subunit 15A. (654 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit. (299 aa)
PHKG1Phosphorylase kinase gamma 1; Belongs to the protein kinase superfamily. (388 aa)
PHKG2Phosphorylase kinase catalytic subunit gamma 2; Belongs to the protein kinase superfamily. (406 aa)
LRRC43Leucine rich repeat containing 43. (628 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
PHKA1Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1227 aa)
PPP1R7Uncharacterized protein. (360 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1096 aa)
F1SFT7_PIGUncharacterized protein. (506 aa)
PPP1R10Serine/threonine-protein phosphatase 1 regulatory subunit 10; Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) [...] (925 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (339 aa)
PPP1R14AProtein phosphatase 1 regulatory subunit 14A; Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. (147 aa)
PHKBPhosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1090 aa)
PPP1CBSerine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progressi [...] (389 aa)
PHKA2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1237 aa)
PPP1R12BProtein phosphatase 1 regulatory subunit. (1012 aa)
ROCK2Rho-associated protein kinase 2; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1- p44/MAPK3 and of p90RSK/RPS6K [...] (1397 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (369 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
PPP1R12CProtein phosphatase 1 regulatory subunit. (775 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1028 aa)
PPP1R3FProtein phosphatase 1 regulatory subunit 3F. (790 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (339 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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