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MCHR1 MCHR1 GALR3 GALR3 PMCH PMCH SSTR1 SSTR1 AGRP AGRP CORT CORT OPRM1 OPRM1 MCHR2 MCHR2 PENK PENK OPRK1 OPRK1 MC3R MC3R NPY1R NPY1R NPY5R NPY5R NPY2R NPY2R GHRL GHRL GHSR GHSR MBOAT4 MBOAT4 SSTR2 SSTR2 PPY PPY MLNR MLNR PYY PYY POMC POMC OPRD1 OPRD1 MC1R MC1R GALR2 GALR2 MC5R MC5R C5AR1 C5AR1 PDYN PDYN OPRL1 OPRL1 SPX SPX SSTR5 SSTR5 LOC110255184 LOC110255184 PSAP PSAP GPR37L1 GPR37L1 NPBWR2 NPBWR2 APLNR APLNR LOC100626378 LOC100626378 NPY NPY MRAP MRAP GAL GAL A0A287B0W3_PIG A0A287B0W3_PIG SST SST APELA APELA PNOC PNOC GALP GALP NPB NPB MLN MLN GALR1 GALR1 APLN APLN GPR37 GPR37 NPW NPW SSTR3 SSTR3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MCHR1Melanin-concentrating hormone receptor 1; Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis. (353 aa)
GALR3Galanin receptor 3; Belongs to the G-protein coupled receptor 1 family. (376 aa)
PMCHPro-MCH preproprotein. (165 aa)
SSTR1Somatostatin receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
AGRPAgouti-related protein; Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R. Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner. (134 aa)
CORTSomatostatin domain-containing protein. (108 aa)
OPRM1Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell typ [...] (418 aa)
MCHR2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (339 aa)
PENKProenkephalin. (274 aa)
OPRK1Opioid receptor kappa 1; Belongs to the G-protein coupled receptor 1 family. (380 aa)
MC3RMelanocortin-3 receptor. (319 aa)
NPY1RNeuropeptide Y receptor type 1; Receptor for neuropeptide Y and peptide YY; Belongs to the G-protein coupled receptor 1 family. (383 aa)
NPY5RNeuropeptide Y receptor type 5; Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders (By similarity); Belongs to the G-protein coupled receptor 1 family. (446 aa)
NPY2RNeuropeptide Y receptor type 2; Receptor for neuropeptide Y and peptide YY; Belongs to the G-protein coupled receptor 1 family. (384 aa)
GHRLAppetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family. (118 aa)
GHSRGrowth hormone secretagogue receptor type 1; Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK- 0677, adenosine). (366 aa)
MBOAT4Uncharacterized protein; Belongs to the membrane-bound acyltransferase family. (433 aa)
SSTR2Somatostatin receptor type 2; Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 [...] (360 aa)
PPYPancreatic prohormone precursor; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions; Belongs to the NPY family. (93 aa)
MLNRMotilin receptor; Belongs to the G-protein coupled receptor 1 family. (406 aa)
PYYPeptide YY(3-36); This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility. (174 aa)
POMCCorticotropin-like intermediary peptide; [Corticotropin]: Stimulates the adrenal glands to release cortisol. [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes. [Met-enkephalin]: Endogenous opiate; Belongs to the POMC family. (381 aa)
OPRD1Delta-type opioid receptor; G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. [...] (372 aa)
MC1RMelanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a role in the regulation of eumelanin (black/brown) and phaeomelanin (red/yellow) synthesis; Belongs to the G-protein coupled receptor 1 family. (320 aa)
GALR2Galanin receptor type 2; Belongs to the G-protein coupled receptor 1 family. (343 aa)
MC5RMelanocortin receptor 5; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins; Belongs to the G-protein coupled receptor 1 family. (305 aa)
C5AR1C5a anaphylatoxin chemotactic receptor 1; Belongs to the G-protein coupled receptor 1 family. (351 aa)
PDYNAlpha-neoendorphin; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). Leumorphin has a typical opiod activity and may have anti- apoptotic effect. (256 aa)
OPRL1Nociceptin receptor; G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide- binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociceptio [...] (456 aa)
SPXSpexin hormone. (118 aa)
SSTR5G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (305 aa)
LOC110255184Uncharacterized protein. (129 aa)
PSAPSaposin-B-Val; Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta- galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha- galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. (573 aa)
GPR37L1G protein-coupled receptor 37 like 1. (459 aa)
NPBWR2Neuropeptides B and W receptor 2; Belongs to the G-protein coupled receptor 1 family. (298 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (383 aa)
LOC100626378Uncharacterized protein. (129 aa)
NPYC-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. (169 aa)
MRAPUncharacterized protein. (176 aa)
GALGalanin message-associated peptide; Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion; Belongs to the galanin family. (337 aa)
A0A287B0W3_PIGUncharacterized protein. (129 aa)
SSTSomatostatin-14; [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH- stimulated secretion of GH1 and LH; the inhibition of ghrelin- stimulated secretion of GH1 can be further increased by neuronostatin. (116 aa)
APELAUncharacterized protein. (54 aa)
PNOCNociceptin. (203 aa)
GALPGalanin-like peptide; Hypothalamic neuropeptide which binds to the G-protein- coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion (By similarity). (175 aa)
NPBUncharacterized protein. (176 aa)
MLNMotilin-associated peptide; Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle; Belongs to the motilin family. (196 aa)
GALR1Galanin receptor 1; Belongs to the G-protein coupled receptor 1 family. (349 aa)
APLNApelin. (77 aa)
GPR37G protein-coupled receptor 37. (614 aa)
NPWNeuropeptide W-23; Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity); Belongs to the neuropeptide B/W family. (152 aa)
SSTR3Somatostatin receptor 3; Belongs to the G-protein coupled receptor 1 family. (421 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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