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VIP VIP GCG GCG SCTR SCTR GIP GIP FAP FAP GLP2R GLP2R SCT SCT VIPR2 VIPR2 ADCYAP1R1 ADCYAP1R1 ADCYAP1 ADCYAP1 VIPR1 VIPR1 GIPR GIPR GLP1R GLP1R GCGR GCGR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VIPVasoactive intestinal peptide; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder; Belongs to the glucagon family. (167 aa)
GCGGlicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] (180 aa)
SCTRSecretin receptor; Belongs to the G-protein coupled receptor 2 family. (443 aa)
GIPGastric inhibitory polypeptide; Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion; Belongs to the glucagon family. (144 aa)
FAPFibroblast activation protein alpha; Belongs to the peptidase S9B family. (760 aa)
GLP2RGlucagon like peptide 2 receptor; Belongs to the G-protein coupled receptor 2 family. (556 aa)
SCTSecretin; Hormone involved in different processes, such as regulation of the pH of the duodenal content, food intake and water homeostasis. Exerts its biological effects by binding to secretin receptor (SCTR), a G-protein coupled receptor expressed in the basolateral domain of several cells. Acts as a key gastrointestinal hormone by regulating the pH of the duodenal content. Secreted by S cells of the duodenum in the crypts of Lieberkuehn and regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the p [...] (135 aa)
VIPR2Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (465 aa)
ADCYAP1R1Pituitary adenylate cyclase-activating polypeptide type I receptor short form; Belongs to the G-protein coupled receptor 2 family. (468 aa)
ADCYAP1Pituitary adenylate cyclase-activating polypeptide 27; Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells (By similarity). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity). (176 aa)
VIPR1Vasoactive intestinal polypeptide receptor 1; This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). Belongs to the G-protein coupled receptor 2 family. (458 aa)
GIPRGastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family. (466 aa)
GLP1RUncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (468 aa)
GCGRG_PROTEIN_RECEP_F2_4 domain-containing protein; Belongs to the G-protein coupled receptor 2 family. (602 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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