(45 nodes) Intermediate filament protein, and Nail development network (Sus scrofa)

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Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	KRT82	Keratin 82; Belongs to the intermediate filament family. (513 aa)
	KRT75	Keratin 75; Belongs to the intermediate filament family. (550 aa)
	LOC100523670	IF rod domain-containing protein; Belongs to the intermediate filament family. (493 aa)
	KRT5	Keratin 5; Belongs to the intermediate filament family. (602 aa)
	KRT72	Keratin 72; Belongs to the intermediate filament family. (508 aa)
	KRT1	Keratin 1; Belongs to the intermediate filament family. (624 aa)
	HOXC13	Homeobox C13. (332 aa)
	PADI3	Peptidyl arginine deiminase 3. (664 aa)
	EPCAM	Epithelial cell adhesion molecule; May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E (By similarity). Belongs to the EPCAM family. (340 aa)
	TMPRSS11B	Transmembrane protease serine; Belongs to the peptidase S1 family. (417 aa)
	KRT35	Keratin 35; Belongs to the intermediate filament family. (455 aa)
	KRT32	Keratin 32; Belongs to the intermediate filament family. (387 aa)
	KRT33A	IF rod domain-containing protein; Belongs to the intermediate filament family. (403 aa)
	KRT39	Keratin 39; Belongs to the intermediate filament family. (490 aa)
	KRT28	Keratin 28; Belongs to the intermediate filament family. (463 aa)
	KRT27	IF rod domain-containing protein; Belongs to the intermediate filament family. (460 aa)
	KRT26	Keratin 26; Belongs to the intermediate filament family. (469 aa)
	DLX3	Distal-less homeobox 3. (287 aa)
	FOXN1	Forkhead box N1. (671 aa)
	KRT74	IF rod domain-containing protein; Belongs to the intermediate filament family. (531 aa)
	DSG4	Desmoglein 4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1042 aa)
	LRRC15	Leucine rich repeat containing 15. (581 aa)
	KRT10	Keratin 10; Belongs to the intermediate filament family. (573 aa)
	CERT1	Ceramide transporter 1. (562 aa)
	LOC100621639	IF rod domain-containing protein; Belongs to the intermediate filament family. (407 aa)
	LOC100516036	IF rod domain-containing protein; Belongs to the intermediate filament family. (422 aa)
	LOC106507258	IF rod domain-containing protein; Belongs to the intermediate filament family. (483 aa)
	KRT71	Keratin 71; Belongs to the intermediate filament family. (525 aa)
	KRT7	Keratin 7; Belongs to the intermediate filament family. (468 aa)
	LOC100513671	Transmembrane protease serine; Belongs to the peptidase S1 family. (416 aa)
	KRT8	Keratin, type II cytoskeletal 8 isoform 2; Belongs to the intermediate filament family. (461 aa)
	KRT40	Keratin 40; Belongs to the intermediate filament family. (427 aa)
	LOC100523123	IF rod domain-containing protein; Belongs to the intermediate filament family. (496 aa)
	TCHH	Uncharacterized protein. (334 aa)
	CFAP45	Cilia and flagella associated protein 45. (603 aa)
	LOC102162785	IF rod domain-containing protein; Belongs to the intermediate filament family. (338 aa)
	KRT2	IF rod domain-containing protein; Belongs to the intermediate filament family. (639 aa)
	OVOL1	Ovo like transcriptional repressor 1. (313 aa)
	KRT14	Keratin 14; Belongs to the intermediate filament family. (515 aa)
	NFAM1	NFAT activating protein with ITAM motif 1. (261 aa)
	VSIG8	V-set and immunoglobulin domain containing 8. (414 aa)
	KRT3	Keratin 3; Belongs to the intermediate filament family. (643 aa)
	KRT18	Keratin 18; Belongs to the intermediate filament family. (423 aa)
	A0A5G2QWB6_PIG	Uncharacterized protein. (979 aa)
	LOC100621844	IF rod domain-containing protein; Belongs to the intermediate filament family. (488 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A5G2QWB6_PIG	DSG4	ENSSSCP00000069244	ENSSSCP00000019365	Uncharacterized protein.	Desmoglein 4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	0.542
A0A5G2QWB6_PIG	KRT1	ENSSSCP00000069244	ENSSSCP00000000266	Uncharacterized protein.	Keratin 1; Belongs to the intermediate filament family.	0.632
A0A5G2QWB6_PIG	KRT10	ENSSSCP00000069244	ENSSSCP00000022207	Uncharacterized protein.	Keratin 10; Belongs to the intermediate filament family.	0.638
A0A5G2QWB6_PIG	KRT14	ENSSSCP00000069244	ENSSSCP00000057471	Uncharacterized protein.	Keratin 14; Belongs to the intermediate filament family.	0.579
A0A5G2QWB6_PIG	KRT5	ENSSSCP00000069244	ENSSSCP00000000263	Uncharacterized protein.	Keratin 5; Belongs to the intermediate filament family.	0.401
A0A5G2QWB6_PIG	TCHH	ENSSSCP00000069244	ENSSSCP00000049788	Uncharacterized protein.	Uncharacterized protein.	0.794
CERT1	KRT26	ENSSSCP00000023319	ENSSSCP00000018506	Ceramide transporter 1.	Keratin 26; Belongs to the intermediate filament family.	0.493
CERT1	KRT39	ENSSSCP00000023319	ENSSSCP00000018501	Ceramide transporter 1.	Keratin 39; Belongs to the intermediate filament family.	0.596
CFAP45	VSIG8	ENSSSCP00000050990	ENSSSCP00000060629	Cilia and flagella associated protein 45.	V-set and immunoglobulin domain containing 8.	0.485
DLX3	FOXN1	ENSSSCP00000018642	ENSSSCP00000018821	Distal-less homeobox 3.	Forkhead box N1.	0.709
DLX3	HOXC13	ENSSSCP00000018642	ENSSSCP00000000295	Distal-less homeobox 3.	Homeobox C13.	0.601
DLX3	KRT14	ENSSSCP00000018642	ENSSSCP00000057471	Distal-less homeobox 3.	Keratin 14; Belongs to the intermediate filament family.	0.510
DLX3	KRT32	ENSSSCP00000018642	ENSSSCP00000018480	Distal-less homeobox 3.	Keratin 32; Belongs to the intermediate filament family.	0.478
DLX3	KRT35	ENSSSCP00000018642	ENSSSCP00000018479	Distal-less homeobox 3.	Keratin 35; Belongs to the intermediate filament family.	0.570
DLX3	OVOL1	ENSSSCP00000018642	ENSSSCP00000056524	Distal-less homeobox 3.	Ovo like transcriptional repressor 1.	0.631
DLX3	PADI3	ENSSSCP00000018642	ENSSSCP00000003780	Distal-less homeobox 3.	Peptidyl arginine deiminase 3.	0.514
DSG4	A0A5G2QWB6_PIG	ENSSSCP00000019365	ENSSSCP00000069244	Desmoglein 4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Uncharacterized protein.	0.542
DSG4	HOXC13	ENSSSCP00000019365	ENSSSCP00000000295	Desmoglein 4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Homeobox C13.	0.741
DSG4	KRT27	ENSSSCP00000019365	ENSSSCP00000018505	Desmoglein 4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	IF rod domain-containing protein; Belongs to the intermediate filament family.	0.427
DSG4	KRT32	ENSSSCP00000019365	ENSSSCP00000018480	Desmoglein 4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Keratin 32; Belongs to the intermediate filament family.	0.496