(17 nodes) Mixed, incl. U2AF complex, and mRNA 3-end processing network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	SRPK1	SRSF protein kinase 1. (831 aa)
	SRSF3	Serine and arginine rich splicing factor 3. (164 aa)
	SRSF11	Uncharacterized protein. (423 aa)
	SRSF9	Uncharacterized protein. (221 aa)
	TRA2B	Transformer 2 beta homolog. (288 aa)
	A0A286ZI50_PIG	RRM domain-containing protein. (184 aa)
	SRSF5	Serine and arginine rich splicing factor 5. (271 aa)
	U2AF1L4	Splicing factor U2AF 35 kDa subunit-like protein isoform 2. (247 aa)
	SRSF2	Serine/arginine-rich splicing factor 2; Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5 [...] (221 aa)
	HNRNPH2	Heterogeneous nuclear ribonucleoprotein H2. (449 aa)
	U2AF2	U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family. (475 aa)
	U2AF1	Splicing factor U2AF 35 kDa subunit; Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron (By similarity). (239 aa)
	SRSF7	Serine/arginine-rich splicing factor 7 isoform 1. (238 aa)
	SRSF10	Serine and arginine rich splicing factor 10. (261 aa)
	SRSF1	Serine/arginine-rich splicing factor 1; Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site- containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octame [...] (253 aa)
	SRSF4	Serine and arginine rich splicing factor 4. (489 aa)
	ZRSR2	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2. (479 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A286ZI50_PIG	HNRNPH2	ENSSSCP00000031134	ENSSSCP00000040592	RRM domain-containing protein.	Heterogeneous nuclear ribonucleoprotein H2.	0.569
A0A286ZI50_PIG	SRPK1	ENSSSCP00000031134	ENSSSCP00000001688	RRM domain-containing protein.	SRSF protein kinase 1.	0.564
A0A286ZI50_PIG	SRSF1	ENSSSCP00000031134	ENSSSCP00000057405	RRM domain-containing protein.	Serine/arginine-rich splicing factor 1; Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site- containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octame [...]	0.809
A0A286ZI50_PIG	SRSF10	ENSSSCP00000031134	ENSSSCP00000051926	RRM domain-containing protein.	Serine and arginine rich splicing factor 10.	0.599
A0A286ZI50_PIG	SRSF2	ENSSSCP00000031134	ENSSSCP00000040547	RRM domain-containing protein.	Serine/arginine-rich splicing factor 2; Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5 [...]	0.433
A0A286ZI50_PIG	SRSF3	ENSSSCP00000031134	ENSSSCP00000001699	RRM domain-containing protein.	Serine and arginine rich splicing factor 3.	0.876
A0A286ZI50_PIG	SRSF4	ENSSSCP00000031134	ENSSSCP00000059217	RRM domain-containing protein.	Serine and arginine rich splicing factor 4.	0.491
A0A286ZI50_PIG	SRSF5	ENSSSCP00000031134	ENSSSCP00000036224	RRM domain-containing protein.	Serine and arginine rich splicing factor 5.	0.726
A0A286ZI50_PIG	SRSF7	ENSSSCP00000031134	ENSSSCP00000046977	RRM domain-containing protein.	Serine/arginine-rich splicing factor 7 isoform 1.	0.770
A0A286ZI50_PIG	SRSF9	ENSSSCP00000031134	ENSSSCP00000010572	RRM domain-containing protein.	Uncharacterized protein.	0.836
A0A286ZI50_PIG	TRA2B	ENSSSCP00000031134	ENSSSCP00000021460	RRM domain-containing protein.	Transformer 2 beta homolog.	0.861
A0A286ZI50_PIG	U2AF1	ENSSSCP00000031134	ENSSSCP00000044103	RRM domain-containing protein.	Splicing factor U2AF 35 kDa subunit; Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron (By similarity).	0.588
A0A286ZI50_PIG	U2AF1L4	ENSSSCP00000031134	ENSSSCP00000037692	RRM domain-containing protein.	Splicing factor U2AF 35 kDa subunit-like protein isoform 2.	0.561
A0A286ZI50_PIG	U2AF2	ENSSSCP00000031134	ENSSSCP00000042718	RRM domain-containing protein.	U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family.	0.541
A0A286ZI50_PIG	ZRSR2	ENSSSCP00000031134	ENSSSCP00000068278	RRM domain-containing protein.	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2.	0.535
HNRNPH2	A0A286ZI50_PIG	ENSSSCP00000040592	ENSSSCP00000031134	Heterogeneous nuclear ribonucleoprotein H2.	RRM domain-containing protein.	0.569
HNRNPH2	SRSF1	ENSSSCP00000040592	ENSSSCP00000057405	Heterogeneous nuclear ribonucleoprotein H2.	Serine/arginine-rich splicing factor 1; Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site- containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octame [...]	0.750
HNRNPH2	SRSF10	ENSSSCP00000040592	ENSSSCP00000051926	Heterogeneous nuclear ribonucleoprotein H2.	Serine and arginine rich splicing factor 10.	0.606
HNRNPH2	SRSF11	ENSSSCP00000040592	ENSSSCP00000004101	Heterogeneous nuclear ribonucleoprotein H2.	Uncharacterized protein.	0.554
HNRNPH2	SRSF2	ENSSSCP00000040592	ENSSSCP00000040547	Heterogeneous nuclear ribonucleoprotein H2.	Serine/arginine-rich splicing factor 2; Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5 [...]	0.680