STRINGSTRING
TIMELESS TIMELESS GINS3 GINS3 MCM9 MCM9 ORC3 ORC3 DNAAF2 DNAAF2 WDHD1 WDHD1 POLE3 POLE3 MCM8 MCM8 MCMBP MCMBP POLA2 POLA2 ORC5 ORC5 ORC4 ORC4 ORC2 ORC2 CDC6 CDC6 POLD3 POLD3 MCM3 MCM3 ORC1 ORC1 CDC45 CDC45 POLD2 POLD2 CLSPN CLSPN GINS1 GINS1 MCM6 MCM6 DBF4 DBF4 GINS2 GINS2 MCM2 MCM2 DNA2 DNA2 MCM4 MCM4 PRIM1 PRIM1 MCM7 MCM7 POLE POLE POLD1 POLD1 CDT1 CDT1 GINS4 GINS4 TIPIN TIPIN PRIM2 PRIM2 MCM10 MCM10 POLD4 POLD4 MCM5 MCM5 MCMDC2 MCMDC2 ORC6 ORC6 CDC7 CDC7 POLA1 POLA1 POLE4 POLE4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TIMELESSTimeless circadian regulator. (1206 aa)
GINS3GINS complex subunit 3. (216 aa)
MCM9DNA helicase MCM9 isoform 2; Belongs to the MCM family. (391 aa)
ORC3Origin recognition complex subunit 3. (758 aa)
DNAAF2Protein kintoun; Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment. (1099 aa)
WDHD1WD repeat and HMG-box DNA binding protein 1. (1129 aa)
POLE3Uncharacterized protein. (171 aa)
MCM8MCM domain-containing protein; Belongs to the MCM family. (831 aa)
MCMBPMinichromosome maintenance complex binding protein. (642 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (584 aa)
ORC5Origin recognition complex subunit 5 isoform 1. (446 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
ORC2Origin recognition complex subunit 2. (578 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (560 aa)
POLD3Uncharacterized protein. (463 aa)
MCM3DNA helicase; Belongs to the MCM family. (808 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (865 aa)
CDC45Cell division cycle 45. (598 aa)
POLD2DNA polymerase delta 2, accessory subunit. (471 aa)
CLSPNClaspin. (1325 aa)
GINS1DNA replication complex GINS protein PSF1. (196 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
DBF4DBF4-type domain-containing protein. (675 aa)
GINS2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa)
MCM2DNA helicase; Belongs to the MCM family. (930 aa)
DNA2DNA replication helicase/nuclease 2. (1084 aa)
MCM4DNA helicase; Belongs to the MCM family. (882 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (419 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2284 aa)
POLD1DNA polymerase. (1152 aa)
CDT1PI-PLC Y-box domain-containing protein. (815 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (192 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (320 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (506 aa)
MCM10Minichromosome maintenance 10 replication initiation factor. (943 aa)
POLD4Uncharacterized protein. (134 aa)
MCM5DNA helicase; Belongs to the MCM family. (733 aa)
MCMDC2Minichromosome maintenance domain containing 2. (681 aa)
ORC6Origin recognition complex subunit 6. (287 aa)
CDC7Cell division cycle 7-related protein kinase isoform X1. (576 aa)
POLA1DNA polymerase. (1652 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (138 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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