(29 nodes) Activation of the pre-replicative complex, and GINS complex network (Sus scrofa)

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second shell of interactors

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Your Input:
	TIMELESS	Timeless circadian regulator. (1206 aa)
	GINS3	GINS complex subunit 3. (216 aa)
	MCM9	DNA helicase MCM9 isoform 2; Belongs to the MCM family. (391 aa)
	ORC3	Origin recognition complex subunit 3. (758 aa)
	MCM8	MCM domain-containing protein; Belongs to the MCM family. (831 aa)
	MCMBP	Minichromosome maintenance complex binding protein. (642 aa)
	ORC5	Origin recognition complex subunit 5 isoform 1. (446 aa)
	ORC4	Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
	ORC2	Origin recognition complex subunit 2. (578 aa)
	CDC6	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (560 aa)
	MCM3	DNA helicase; Belongs to the MCM family. (808 aa)
	ORC1	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (865 aa)
	CDC45	Cell division cycle 45. (598 aa)
	CLSPN	Claspin. (1325 aa)
	GINS1	DNA replication complex GINS protein PSF1. (196 aa)
	MCM6	DNA helicase; Belongs to the MCM family. (821 aa)
	DBF4	DBF4-type domain-containing protein. (675 aa)
	GINS2	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa)
	MCM2	DNA helicase; Belongs to the MCM family. (930 aa)
	MCM4	DNA helicase; Belongs to the MCM family. (882 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
	CDT1	PI-PLC Y-box domain-containing protein. (815 aa)
	GINS4	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (192 aa)
	TIPIN	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (320 aa)
	MCM10	Minichromosome maintenance 10 replication initiation factor. (943 aa)
	MCM5	DNA helicase; Belongs to the MCM family. (733 aa)
	MCMDC2	Minichromosome maintenance domain containing 2. (681 aa)
	ORC6	Origin recognition complex subunit 6. (287 aa)
	CDC7	Cell division cycle 7-related protein kinase isoform X1. (576 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC45	CDC6	ENSSSCP00000030798	ENSSSCP00000018515	Cell division cycle 45.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.958
CDC45	CDC7	ENSSSCP00000030798	ENSSSCP00000068885	Cell division cycle 45.	Cell division cycle 7-related protein kinase isoform X1.	0.847
CDC45	CDT1	ENSSSCP00000030798	ENSSSCP00000052950	Cell division cycle 45.	PI-PLC Y-box domain-containing protein.	0.982
CDC45	CLSPN	ENSSSCP00000030798	ENSSSCP00000032585	Cell division cycle 45.	Claspin.	0.939
CDC45	DBF4	ENSSSCP00000030798	ENSSSCP00000038261	Cell division cycle 45.	DBF4-type domain-containing protein.	0.925
CDC45	GINS1	ENSSSCP00000030798	ENSSSCP00000036477	Cell division cycle 45.	DNA replication complex GINS protein PSF1.	0.990
CDC45	GINS2	ENSSSCP00000030798	ENSSSCP00000040025	Cell division cycle 45.	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family.	0.995
CDC45	GINS3	ENSSSCP00000030798	ENSSSCP00000003022	Cell division cycle 45.	GINS complex subunit 3.	0.993
CDC45	GINS4	ENSSSCP00000030798	ENSSSCP00000054488	Cell division cycle 45.	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family.	0.993
CDC45	MCM10	ENSSSCP00000030798	ENSSSCP00000059636	Cell division cycle 45.	Minichromosome maintenance 10 replication initiation factor.	0.998
CDC45	MCM2	ENSSSCP00000030798	ENSSSCP00000041765	Cell division cycle 45.	DNA helicase; Belongs to the MCM family.	0.998
CDC45	MCM3	ENSSSCP00000030798	ENSSSCP00000019950	Cell division cycle 45.	DNA helicase; Belongs to the MCM family.	0.995
CDC45	MCM4	ENSSSCP00000030798	ENSSSCP00000047671	Cell division cycle 45.	DNA helicase; Belongs to the MCM family.	0.998
CDC45	MCM5	ENSSSCP00000030798	ENSSSCP00000063270	Cell division cycle 45.	DNA helicase; Belongs to the MCM family.	0.996
CDC45	MCM6	ENSSSCP00000030798	ENSSSCP00000037726	Cell division cycle 45.	DNA helicase; Belongs to the MCM family.	0.997
CDC45	MCM7	ENSSSCP00000030798	ENSSSCP00000050669	Cell division cycle 45.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.996
CDC45	MCM8	ENSSSCP00000030798	ENSSSCP00000007509	Cell division cycle 45.	MCM domain-containing protein; Belongs to the MCM family.	0.927
CDC45	MCM9	ENSSSCP00000030798	ENSSSCP00000004585	Cell division cycle 45.	DNA helicase MCM9 isoform 2; Belongs to the MCM family.	0.931
CDC45	MCMBP	ENSSSCP00000030798	ENSSSCP00000011387	Cell division cycle 45.	Minichromosome maintenance complex binding protein.	0.615
CDC45	MCMDC2	ENSSSCP00000030798	ENSSSCP00000063790	Cell division cycle 45.	Minichromosome maintenance domain containing 2.	0.833