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| | ECI2 | Enoyl-CoA delta isomerase 2. (415 aa) |
| | HMGCLL1 | 3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1. (425 aa) |
| | PPARD | Peroxisome proliferator-activated receptor delta. (441 aa) |
| | ACSBG1 | Acyl-CoA synthetase bubblegum family member 1. (709 aa) |
| | ALDH6A1 | Methylmalonate-semialdehyde dehydrogenase acylating, mitochondrial isoform 1. (534 aa) |
| | ETFB | Electron transfer flavoprotein subunit beta; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF- ubiquinone oxidoreductase. Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role. (255 aa) |
| | ECHDC1 | Ethylmalonyl-CoA decarboxylase 1; Belongs to the enoyl-CoA hydratase/isomerase family. (306 aa) |
| | FABP7 | FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (166 aa) |
| | ELOVL4 | Elongation of very long chain fatty acids protein 4; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane [...] (321 aa) |
| | ACAA2 | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa) |
| | HACD3 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (362 aa) |
| | FABP1 | Fatty acid-binding protein, liver; Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes. Binds cholesterol. Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (151 aa) |
| | HADHB | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (511 aa) |
| | HADHA | Trifunctional enzyme subunit alpha, mitochondrial; Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional en [...] (763 aa) |
| | SCD5 | Stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family. (332 aa) |
| | AUH | Methylglutaconyl-CoA hydratase, mitochondrial isoform X1; Belongs to the enoyl-CoA hydratase/isomerase family. (338 aa) |
| | AACS | Acetoacetyl-CoA synthetase. (795 aa) |
| | ACAD10 | Acyl-CoA dehydrogenase family member 10. (1036 aa) |
| | ELOVL3 | Elongation of very long chain fatty acids protein 3; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precurs [...] (270 aa) |
| | OXSM | 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (460 aa) |
| | ACAA1 | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (432 aa) |
| | BDH1 | D-beta-hydroxybutyrate dehydrogenase, mitochondrial; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (346 aa) |
| | CPT1A | Uncharacterized protein; Belongs to the carnitine/choline acetyltransferase family. (771 aa) |
| | FADS1 | Cytochrome b5 heme-binding domain-containing protein. (481 aa) |
| | AASDHPPT | L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase isoform X1. (306 aa) |
| | ACADL | Long-chain specific acyl-CoA dehydrogenase, mitochondrial; Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogenas [...] (430 aa) |
| | CARTPT | Cocaine- and amphetamine-regulated transcript protein; Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. Belongs to the CART family. (116 aa) |
| | FABP6 | Gastrotropin; Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By similarity). Stimulates gastric acid and pepsinogen secretion. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (143 aa) |
| | ACSM5 | Acyl-coenzyme A synthetase ACSM5, mitochondrial isoform 1. (579 aa) |
| | PECR | Peroxisomal trans-2-enoyl-CoA reductase. (303 aa) |
| | FASN | Uncharacterized protein. (1430 aa) |
| | ACSL5 | Acyl-CoA synthetase long chain family member 5. (705 aa) |
| | HSD17B4 | Peroxisomal multifunctional enzyme type 2 isoform 2. (737 aa) |
| | BDH2 | 3-hydroxybutyrate dehydrogenase type 2 isoform X2. (245 aa) |
| | EHHADH | Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (731 aa) |
| | HSD17B12 | Hydroxysteroid 17-beta dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (312 aa) |
| | ACAT1 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (426 aa) |
| | ELOVL5 | Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (325 aa) |
| | HSD17B8 | Estradiol 17-beta-dehydrogenase 8; NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heterotetramer with CBR4 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis. Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (292 aa) |
| | HSD17B10 | Hydroxysteroid 17-beta dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (293 aa) |
| | PPT2 | Palmitoyl-protein thioesterase 2. (309 aa) |
| | MCAT | Malonyl-CoA-acyl carrier protein transacylase. (483 aa) |
| | ACSS3 | Acyl-CoA synthetase short-chain family member 3, mitochondrial isoform 1. (686 aa) |
| | ETFA | Electron transfer flavoprotein subunit alpha. (369 aa) |
| | HMGCS2 | Hydroxymethylglutaryl-CoA synthase, mitochondrial; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase; Belongs to the thiolase-like superfamily. HMG-CoA synthase family. (508 aa) |
| | ACOX1 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (660 aa) |
| | HACD1 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (288 aa) |
| | AASDH | Aminoadipate-semialdehyde dehydrogenase. (1076 aa) |
| | FABP4 | Fatty acid-binding protein, adipocyte; Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity). Involved in the regulation of intramuscular fat accretion ; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa) |
| | FABP5 | FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (235 aa) |
| | ELOVL6 | Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...] (265 aa) |
| | CRAT | Carnitine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (745 aa) |
| | LOC110261008 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (308 aa) |
| | HACD4 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (232 aa) |
| | FABP3 | Fatty acid-binding protein, heart; FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. (133 aa) |
| | FABP2 | Fatty acid-binding protein, intestinal; FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor (By similarity). (132 aa) |
| | ACADS | Short-chain specific acyl-CoA dehydrogenase, mitochondrial; Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chai [...] (612 aa) |
| | ECHS1 | Enoyl-CoA hydratase, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. (328 aa) |
| | HACD2 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (254 aa) |
| | CPT1C | Carnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family. (732 aa) |
| | ECH1 | Enoyl-CoA hydratase 1; Belongs to the enoyl-CoA hydratase/isomerase family. (368 aa) |
| | LOC100522040 | Formiminotransferase N-terminal subdomain-containing protein isoform 1. (328 aa) |
| | ACOX2 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (681 aa) |
| | ACSL1 | Acyl-CoA synthetase long chain family member 1. (771 aa) |
| | ACSBG2 | Acyl-CoA synthetase bubblegum family member 2. (674 aa) |
| | CPT1B | Carnitine O-palmitoyltransferase 1, muscle isoform. (807 aa) |
| | ACOXL | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (708 aa) |
| | ACACA | Acetyl-CoA carboxylase alpha. (2383 aa) |
| | ACAT2 | Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (447 aa) |
| | HTD2 | MaoC-like domain-containing protein. (180 aa) |
| | ELOVL2 | Elongation of very long chain fatty acids protein 2; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production [...] (347 aa) |
| | PPT1 | Palmitoyl-protein thioesterase 1. (305 aa) |
| | SLC27A1 | Solute carrier family 27 (Fatty acid transporter), member 1. (646 aa) |
| | DBI | Acyl-CoA-binding protein; Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor; Belongs to the ACBP family. (88 aa) |
| | ELOVL1 | Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that [...] (314 aa) |
| | ACADSB | Acyl-CoA dehydrogenase short/branched chain. (432 aa) |
| | PCCA | Propionyl-CoA carboxylase alpha chain, mitochondrial; This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl- CoA/(S)-methylmalonyl-CoA. Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domai [...] (730 aa) |
| | CRYL1 | Lambda-crystallin homolog. (369 aa) |
| | CROT | Carn_acyltransf domain-containing protein; Belongs to the carnitine/choline acetyltransferase family. (612 aa) |
| | MCCC2 | Methylcrotonoyl-CoA carboxylase 2. (555 aa) |
| | ACSL3 | Acyl-CoA synthetase long chain family member 3. (729 aa) |
| | HADH | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; Plays an essential role in the mitochondrial beta-oxidation of short chain fatty acids. Exerts it highest activity toward 3- hydroxybutyryl-CoA; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (314 aa) |
| | MCCC1 | Methylcrotonoyl-CoA carboxylase 1. (911 aa) |
| | ACSS2 | Acetyl-coenzyme A synthetase, cytoplasmic isoform X1. (714 aa) |
| | ACSL4 | Acyl-CoA synthetase long chain family member 4. (711 aa) |
| | GCDH | Glutaryl-CoA dehydrogenase, mitochondrial; Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L- hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. (438 aa) |
| | ACSL6 | Long-chain-fatty-acid--CoA ligase 6 isoform X1. (722 aa) |
| | TECR | S5A_REDUCTASE domain-containing protein. (528 aa) |
| | MLYCD | Malonyl-CoA decarboxylase. (499 aa) |
| | ETFDH | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial; Accepts electrons from ETF and reduces ubiquinone. (615 aa) |
| | HIBCH | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (386 aa) |
| | ACOX3 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (720 aa) |
| | A0A5G2QIY4_PIG | Uncharacterized protein. (60 aa) |
| | PCCB | Propionyl-CoA carboxylase beta chain, mitochondrial; This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl- CoA/(S)-methylmalonyl-CoA. Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain [...] (558 aa) |
| | ECHDC2 | Enoyl-CoA hydratase domain containing 2; Belongs to the enoyl-CoA hydratase/isomerase family. (335 aa) |
| | CBR4 | Carbonyl reductase 4; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (263 aa) |
| | A0A5G2QSB6_PIG | Uncharacterized protein. (146 aa) |
| | HIBADH | 3-hydroxyisobutyrate dehydrogenase. (377 aa) |
| | ACADM | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta-oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). (454 aa) |
| | SLC27A4 | Solute carrier family 27 member 4. (673 aa) |
| | ACACB | Biotin carboxylation domain-containing protein. (229 aa) |
| | OXCT1 | Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (562 aa) |
| | ACADVL | Acyl-CoA dehydrogenase very long chain. (681 aa) |
| | DECR1 | Uncharacterized protein. (348 aa) |
| | CPT2 | Carn_acyltransf domain-containing protein; Belongs to the carnitine/choline acetyltransferase family. (658 aa) |
| | HSDL2 | Hydroxysteroid dehydrogenase like 2. (418 aa) |
| | IVD | Uncharacterized protein. (568 aa) |
| | SCD | Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (By similarity). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid ox [...] (425 aa) |
