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ECI2 ECI2 HMGCLL1 HMGCLL1 ALDH6A1 ALDH6A1 ETFB ETFB ECHDC1 ECHDC1 ACAA2 ACAA2 HADHB HADHB HADHA HADHA AUH AUH AACS AACS ACAD10 ACAD10 OXSM OXSM ACAA1 ACAA1 BDH1 BDH1 AASDHPPT AASDHPPT ACADL ACADL CARTPT CARTPT PECR PECR FASN FASN HSD17B4 HSD17B4 BDH2 BDH2 EHHADH EHHADH ACAT1 ACAT1 HSD17B8 HSD17B8 HSD17B10 HSD17B10 MCAT MCAT ACSS3 ACSS3 ETFA ETFA HMGCS2 HMGCS2 ACOX1 ACOX1 AASDH AASDH CRAT CRAT ACADS ACADS ECHS1 ECHS1 ECH1 ECH1 ACOX2 ACOX2 ACSL1 ACSL1 ACOXL ACOXL ACACA ACACA ACAT2 ACAT2 HTD2 HTD2 DBI DBI ACADSB ACADSB PCCA PCCA CRYL1 CRYL1 MCCC2 MCCC2 HADH HADH MCCC1 MCCC1 ACSS2 ACSS2 GCDH GCDH MLYCD MLYCD ETFDH ETFDH HIBCH HIBCH ACOX3 ACOX3 A0A5G2QIY4_PIG A0A5G2QIY4_PIG PCCB PCCB ECHDC2 ECHDC2 CBR4 CBR4 A0A5G2QSB6_PIG A0A5G2QSB6_PIG HIBADH HIBADH ACADM ACADM ACACB ACACB OXCT1 OXCT1 ACADVL ACADVL DECR1 DECR1 CPT2 CPT2 HSDL2 HSDL2 IVD IVD
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ECI2Enoyl-CoA delta isomerase 2. (415 aa)
HMGCLL13-hydroxymethyl-3-methylglutaryl-CoA lyase like 1. (425 aa)
ALDH6A1Methylmalonate-semialdehyde dehydrogenase acylating, mitochondrial isoform 1. (534 aa)
ETFBElectron transfer flavoprotein subunit beta; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF- ubiquinone oxidoreductase. Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role. (255 aa)
ECHDC1Ethylmalonyl-CoA decarboxylase 1; Belongs to the enoyl-CoA hydratase/isomerase family. (306 aa)
ACAA2Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
HADHBUncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (511 aa)
HADHATrifunctional enzyme subunit alpha, mitochondrial; Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional en [...] (763 aa)
AUHMethylglutaconyl-CoA hydratase, mitochondrial isoform X1; Belongs to the enoyl-CoA hydratase/isomerase family. (338 aa)
AACSAcetoacetyl-CoA synthetase. (795 aa)
ACAD10Acyl-CoA dehydrogenase family member 10. (1036 aa)
OXSM3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (460 aa)
ACAA1Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (432 aa)
BDH1D-beta-hydroxybutyrate dehydrogenase, mitochondrial; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (346 aa)
AASDHPPTL-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase isoform X1. (306 aa)
ACADLLong-chain specific acyl-CoA dehydrogenase, mitochondrial; Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogenas [...] (430 aa)
CARTPTCocaine- and amphetamine-regulated transcript protein; Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. Belongs to the CART family. (116 aa)
PECRPeroxisomal trans-2-enoyl-CoA reductase. (303 aa)
FASNUncharacterized protein. (1430 aa)
HSD17B4Peroxisomal multifunctional enzyme type 2 isoform 2. (737 aa)
BDH23-hydroxybutyrate dehydrogenase type 2 isoform X2. (245 aa)
EHHADHEnoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (731 aa)
ACAT1Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (426 aa)
HSD17B8Estradiol 17-beta-dehydrogenase 8; NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heterotetramer with CBR4 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis. Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (292 aa)
HSD17B10Hydroxysteroid 17-beta dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (293 aa)
MCATMalonyl-CoA-acyl carrier protein transacylase. (483 aa)
ACSS3Acyl-CoA synthetase short-chain family member 3, mitochondrial isoform 1. (686 aa)
ETFAElectron transfer flavoprotein subunit alpha. (369 aa)
HMGCS2Hydroxymethylglutaryl-CoA synthase, mitochondrial; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase; Belongs to the thiolase-like superfamily. HMG-CoA synthase family. (508 aa)
ACOX1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (660 aa)
AASDHAminoadipate-semialdehyde dehydrogenase. (1076 aa)
CRATCarnitine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (745 aa)
ACADSShort-chain specific acyl-CoA dehydrogenase, mitochondrial; Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chai [...] (612 aa)
ECHS1Enoyl-CoA hydratase, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. (328 aa)
ECH1Enoyl-CoA hydratase 1; Belongs to the enoyl-CoA hydratase/isomerase family. (368 aa)
ACOX2Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (681 aa)
ACSL1Acyl-CoA synthetase long chain family member 1. (771 aa)
ACOXLAcyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (708 aa)
ACACAAcetyl-CoA carboxylase alpha. (2383 aa)
ACAT2Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (447 aa)
HTD2MaoC-like domain-containing protein. (180 aa)
DBIAcyl-CoA-binding protein; Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor; Belongs to the ACBP family. (88 aa)
ACADSBAcyl-CoA dehydrogenase short/branched chain. (432 aa)
PCCAPropionyl-CoA carboxylase alpha chain, mitochondrial; This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl- CoA/(S)-methylmalonyl-CoA. Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domai [...] (730 aa)
CRYL1Lambda-crystallin homolog. (369 aa)
MCCC2Methylcrotonoyl-CoA carboxylase 2. (555 aa)
HADHHydroxyacyl-coenzyme A dehydrogenase, mitochondrial; Plays an essential role in the mitochondrial beta-oxidation of short chain fatty acids. Exerts it highest activity toward 3- hydroxybutyryl-CoA; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (314 aa)
MCCC1Methylcrotonoyl-CoA carboxylase 1. (911 aa)
ACSS2Acetyl-coenzyme A synthetase, cytoplasmic isoform X1. (714 aa)
GCDHGlutaryl-CoA dehydrogenase, mitochondrial; Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L- hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. (438 aa)
MLYCDMalonyl-CoA decarboxylase. (499 aa)
ETFDHElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial; Accepts electrons from ETF and reduces ubiquinone. (615 aa)
HIBCH3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (386 aa)
ACOX3Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (720 aa)
A0A5G2QIY4_PIGUncharacterized protein. (60 aa)
PCCBPropionyl-CoA carboxylase beta chain, mitochondrial; This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl- CoA/(S)-methylmalonyl-CoA. Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain [...] (558 aa)
ECHDC2Enoyl-CoA hydratase domain containing 2; Belongs to the enoyl-CoA hydratase/isomerase family. (335 aa)
CBR4Carbonyl reductase 4; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (263 aa)
A0A5G2QSB6_PIGUncharacterized protein. (146 aa)
HIBADH3-hydroxyisobutyrate dehydrogenase. (377 aa)
ACADMMedium-chain specific acyl-CoA dehydrogenase, mitochondrial; Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta-oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). (454 aa)
ACACBBiotin carboxylation domain-containing protein. (229 aa)
OXCT1Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (562 aa)
ACADVLAcyl-CoA dehydrogenase very long chain. (681 aa)
DECR1Uncharacterized protein. (348 aa)
CPT2Carn_acyltransf domain-containing protein; Belongs to the carnitine/choline acetyltransferase family. (658 aa)
HSDL2Hydroxysteroid dehydrogenase like 2. (418 aa)
IVDUncharacterized protein. (568 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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