STRINGSTRING
SQLE SQLE CYP7B1 CYP7B1 HSD17B7 HSD17B7 FDPS FDPS PMVK PMVK MVK MVK AS3MT AS3MT TM7SF2 TM7SF2 AKR1D1 AKR1D1 HMGCS1 HMGCS1 CYP27A1 CYP27A1 DHCR7 DHCR7 IDI1 IDI1 SC5D SC5D FDFT1 FDFT1 LSS LSS MSMO1 MSMO1 HSD3B7 HSD3B7 MVD MVD SDR42E1 SDR42E1 CYP8B1 CYP8B1 CYP51A1 CYP51A1 FAXDC2 FAXDC2 NSDHL NSDHL HMGCR HMGCR SIGMAR1 SIGMAR1 EBP EBP CH25H CH25H ERG28 ERG28
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SQLESqualene monooxygenase. (574 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (510 aa)
HSD17B7Hydroxysteroid 17-beta dehydrogenase 7. (334 aa)
FDPSFarnesyl pyrophosphate synthase isoform X1; Belongs to the FPP/GGPP synthase family. (421 aa)
PMVKPhosphomevalonate kinase. (192 aa)
MVKMevalonate kinase. (454 aa)
AS3MTArsenite methyltransferase. (395 aa)
TM7SF2Transmembrane 7 superfamily member 2. (399 aa)
AKR1D13-oxo-5-beta-steroid 4-dehydrogenase isoform 1. (326 aa)
HMGCS13-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (576 aa)
CYP27A1Uncharacterized protein; Belongs to the cytochrome P450 family. (581 aa)
DHCR77-dehydrocholesterol reductase. (475 aa)
IDI1Isopentenyl-diphosphate delta isomerase 1. (227 aa)
SC5DSterol-C5-desaturase; Belongs to the sterol desaturase family. (336 aa)
FDFT1Farnesyl-diphosphate farnesyltransferase 1. (417 aa)
LSSTerpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. (746 aa)
MSMO1Methylsterol monooxygenase 1; Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol; Belongs to the sterol desaturase family. (293 aa)
HSD3B7Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7. (410 aa)
MVDMevalonate diphosphate decarboxylase. (474 aa)
SDR42E1Short-chain dehydrogenase/reductase family 42E member 1 isoform X1; Belongs to the 3-beta-HSD family. (394 aa)
CYP8B15-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase; Involved in bile acid synthesis and is responsible for the conversion of 5 beta-cholestane-3-alpha,7-alpha-diol into 5 beta- cholestane-3-alpha,7-alpha,12-alpha triol. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. The enzyme can also hydroxylate the substrate at the 25 and 26 position, but to a lesser extent. (501 aa)
CYP51A1Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] (503 aa)
FAXDC2Fatty acid hydroxylase domain containing 2; Belongs to the sterol desaturase family. (338 aa)
NSDHLSterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; Belongs to the 3-beta-HSD family. (363 aa)
HMGCR3-hydroxy-3-methylglutaryl-coenzyme A reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins. (887 aa)
SIGMAR1Sigma non-opioid intracellular receptor 1. (223 aa)
EBPEmopamil binding protein (Sterol isomerase). (230 aa)
CH25HCholesterol 25-hydroxylase; Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. Plays a key role in cell positioning and movement in lymphoid tissues: 25- hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25- dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory eleme [...] (311 aa)
ERG28Ergosterol biosynthesis 28 homolog. (211 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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