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ADSL ADSL TPMT TPMT HDDC3 HDDC3 THTPA THTPA PNP PNP AK7 AK7 APRT APRT NT5C1A NT5C1A MTAP MTAP UCK1 UCK1 ENTPD8 ENTPD8 NME7 NME7 NME4 NME4 NME3 NME3 DGUOK DGUOK XDH XDH LOC100516797 LOC100516797 PPAT PPAT NTPCR NTPCR ENTPD1 ENTPD1 NUDT2 NUDT2 NME6 NME6 UPRT UPRT NUDT12 NUDT12 IMPDH1 IMPDH1 NT5M NT5M CDA CDA ENTPD3 ENTPD3 GMPS GMPS NT5C NT5C UPP2 UPP2 NT5E NT5E AK1 AK1 AK4 AK4 NT5C3B NT5C3B DUT DUT UPP1 UPP1 GMPR2 GMPR2 ENPP1 ENPP1 RRM1 RRM1 HPRT1 HPRT1 DCTD DCTD ENTPD2 ENTPD2 UCK2 UCK2 PAICS PAICS RRM2 RRM2 CANT1 CANT1 NUDT16 NUDT16 NME1 NME1 GMPR GMPR AK9 AK9 CTPS1 CTPS1 QRICH1 QRICH1 ADSS1 ADSS1 NT5C2 NT5C2 ADSS2 ADSS2 TK2 TK2 ITPA ITPA ADA2 ADA2 TK1 TK1 AMPD1 AMPD1 ENTPD5 ENTPD5 AK2 AK2 NME2 NME2 CTPS2 CTPS2 CMPK1 CMPK1 TPK1 TPK1 ADK ADK ADA ADA GDA GDA AK6 AK6 CMPK2 CMPK2 AK5 AK5
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ADSLAdenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (501 aa)
TPMTThiopurine S-methyltransferase. (245 aa)
HDDC3HD domain containing 3. (233 aa)
THTPAThiamine-triphosphatase; Hydrolase highly specific for thiamine triphosphate (ThTP). (230 aa)
PNPPurine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (301 aa)
AK7Adenylate kinase 7 isoform 1. (724 aa)
APRTPribosyltran domain-containing protein. (244 aa)
NT5C1A5'-nucleotidase, cytosolic IA. (365 aa)
MTAPS-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. (363 aa)
UCK1Uridine-cytidine kinase; Belongs to the uridine kinase family. (277 aa)
ENTPD8Ectonucleoside triphosphate diphosphohydrolase 8; Belongs to the GDA1/CD39 NTPase family. (495 aa)
NME7Nucleoside diphosphate kinase 7; Belongs to the NDK family. (377 aa)
NME4Nucleoside diphosphate kinase. (187 aa)
NME3Nucleoside diphosphate kinase. (169 aa)
DGUOKDeoxyguanosine kinase, mitochondrial isoform X1. (277 aa)
XDHXanthine dehydrogenase/oxidase. (1336 aa)
LOC100516797Uncharacterized protein. (633 aa)
PPATAmidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (539 aa)
NTPCRCancer-related nucleoside-triphosphatase isoform 1. (189 aa)
ENTPD1Ectonucleoside triphosphate diphosphohydrolase 1 27 kDa subunit; In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. (510 aa)
NUDT2Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis. (147 aa)
NME6Nucleoside diphosphate kinase. (186 aa)
UPRTUracil phosphoribosyltransferase homolog. (304 aa)
NUDT12Nudix hydrolase 12. (472 aa)
IMPDH1Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (571 aa)
NT5M5',3'-nucleotidase, mitochondrial. (228 aa)
CDACytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (146 aa)
ENTPD3Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family. (500 aa)
GMPSGuanine monophosphate synthase. (699 aa)
NT5C5', 3'-nucleotidase, cytosolic. (255 aa)
UPP2Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (344 aa)
NT5E5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (574 aa)
AK1Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (268 aa)
AK4Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. (223 aa)
NT5C3B5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (300 aa)
DUTDeoxyuridine triphosphatase. (224 aa)
UPP1Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (410 aa)
GMPR2GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (352 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (878 aa)
RRM1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (790 aa)
HPRT1Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). (224 aa)
DCTDdCMP deaminase. (188 aa)
ENTPD2Ectonucleoside triphosphate diphosphohydrolase 2 isoform 1; Belongs to the GDA1/CD39 NTPase family. (495 aa)
UCK2Uridine-cytidine kinase; Belongs to the uridine kinase family. (261 aa)
PAICSAIRC domain-containing protein. (425 aa)
RRM2Uncharacterized protein. (439 aa)
CANT1Calcium activated nucleotidase 1. (371 aa)
NUDT16Nudix hydrolase 16. (211 aa)
NME1Nucleoside diphosphate kinase. (152 aa)
GMPRIMPDH domain-containing protein. (485 aa)
AK9Uncharacterized protein. (719 aa)
CTPS1CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (591 aa)
QRICH1Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (1225 aa)
ADSS1Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. (452 aa)
NT5C25'-nucleotidase, cytosolic II. (570 aa)
ADSS2Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. Belongs to the adenylosuccinate synthetase family. (412 aa)
TK2Thymidine kinase 2. (318 aa)
ITPAInosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. (221 aa)
ADA2Adenosine deaminase 2; Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity (By similarity). (509 aa)
TK1Thymidine kinase. (229 aa)
AMPD1AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (750 aa)
ENTPD5Ectonucleoside triphosphate diphosphohydrolase 5 (inactive); Belongs to the GDA1/CD39 NTPase family. (483 aa)
AK2Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (267 aa)
NME2Nucleoside diphosphate kinase B; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically. Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE I [...] (404 aa)
CTPS2CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (620 aa)
CMPK1UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (206 aa)
TPK1Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family. (281 aa)
ADKAdenosine kinase. (362 aa)
ADAAdenosine deaminase. (409 aa)
GDAGuanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (446 aa)
AK6Adenylate kinase isoenzyme 6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation; Belongs to the adenylate kinase family. AK6 subfamily. (213 aa)
CMPK2Cytidine/uridine monophosphate kinase 2. (449 aa)
AK5Adenylate kinase 5; Belongs to the adenylate kinase family. (573 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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