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| | NUMA1 | Nuclear mitotic apparatus protein 1. (2134 aa) |
| | ANKRD53 | Ankyrin repeat domain 53. (466 aa) |
| | A0A287BMT3_PIG | Uncharacterized protein; Belongs to the calmodulin family. (90 aa) |
| | PLK4 | Polo like kinase 4. (964 aa) |
| | LATS2 | Serine/threonine-protein kinase LATS2 isoform X1. (1041 aa) |
| | TBCCD1 | TBCC domain-containing protein 1 isoform a. (557 aa) |
| | RMDN3 | Regulator of microtubule dynamics 3. (470 aa) |
| | VPS4B | Vacuolar protein sorting-associated protein 4B; Belongs to the AAA ATPase family. (444 aa) |
| | DCTN1 | CAP-Gly domain-containing protein. (1281 aa) |
| | YPEL5 | Protein yippee-like; Belongs to the yippee family. (134 aa) |
| | FAM161A | FAM161 centrosomal protein A. (720 aa) |
| | TPT1 | Translationally-controlled tumor protein; Involved in calcium binding and microtubule stabilization. (245 aa) |
| | WDR60 | WD repeat domain 60. (1029 aa) |
| | PSRC1 | Proline and serine rich coiled-coil 1. (362 aa) |
| | CDC25B | M-phase inducer phosphatase 2 isoform 1. (631 aa) |
| | NIN | Ninein. (2136 aa) |
| | EML1 | EMAP like 1. (923 aa) |
| | DYNC1I1 | Cytoplasmic dynein 1 intermediate chain 1 isoform X1. (645 aa) |
| | SPAG5 | Uncharacterized protein. (1193 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (560 aa) |
| | F1RRU3_PIG | Uncharacterized protein. (503 aa) |
| | BOD1 | Uncharacterized protein. (267 aa) |
| | PLK2 | Serine/threonine-protein kinase PLK. (685 aa) |
| | CENPF | Centromere protein F. (3035 aa) |
| | ZW10 | Centromere/kinetochore protein zw10 homolog. (779 aa) |
| | PPP2CA | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). (309 aa) |
| | MISP3 | Uncharacterized protein. (451 aa) |
| | PLK5 | Serine/threonine-protein kinase PLK. (611 aa) |
| | SMC1A | Structural maintenance of chromosomes protein. (1298 aa) |
| | POC1A | POC1 centriolar protein A. (410 aa) |
| | SGO1 | Shugoshin 1. (529 aa) |
| | CALML5 | Calmodulin like 5. (149 aa) |
| | ABRAXAS2 | Abraxas 2, BRISC complex subunit. (441 aa) |
| | SMC3 | Structural maintenance of chromosomes protein. (1217 aa) |
| | KIF11 | Kinesin-like protein KIF11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1059 aa) |
| | KLHL22 | Kelch like family member 22. (634 aa) |
| | TUBGCP3 | Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family. (910 aa) |
| | KATNAL1 | Katanin p60 ATPase-containing subunit A-like 1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neur [...] (490 aa) |
| | ALPK1 | Alpha kinase 1. (1241 aa) |
| | F1S145_PIG | Uncharacterized protein; Belongs to the calmodulin family. (196 aa) |
| | SMC6 | Structural maintenance of chromosomes protein 6 isoform X2. (1097 aa) |
| | BIRC6 | Baculoviral IAP repeat containing 6. (4843 aa) |
| | SPOUT1 | Putative methyltransferase C9orf114 homolog isoform X1. (398 aa) |
| | ODF2 | Outer dense fiber of sperm tails 2. (913 aa) |
| | DLGAP5 | DLG associated protein 5. (849 aa) |
| | MAPKBP1 | Mitogen-activated protein kinase binding protein 1. (1502 aa) |
| | HAUS1 | HAUS augmin-like complex subunit 1. (278 aa) |
| | CDC20 | Cell division cycle protein 20 homolog; Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentia [...] (499 aa) |
| | PLK3 | Serine/threonine-protein kinase PLK. (647 aa) |
| | MTCL1 | Microtubule crosslinking factor 1. (1601 aa) |
| | AUNIP | Aurora kinase A and ninein interacting protein. (385 aa) |
| | TMEM201 | Transmembrane protein 201 isoform X1. (667 aa) |
| | WDR62 | WD repeat-containing protein 62; Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (By similarity). Plays a role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (By similarity). (1541 aa) |
| | NEDD9 | Neural precursor cell expressed, developmentally down-regulated 9. (829 aa) |
| | TUBGCP6 | Tubulin gamma complex associated protein 6. (1383 aa) |
| | POC1B | POC1 centriolar protein B. (478 aa) |
| | CKAP2L | Cytoskeleton-associated protein 2-like isoform 1. (771 aa) |
| | UMOD | Uromodulin. (642 aa) |
| | SBDS | Ribosome maturation protein SBDS. (250 aa) |
| | CDC14A | Cell division cycle 14A. (626 aa) |
| | CSPP1 | Centrosome and spindle pole associated protein 1. (1240 aa) |
| | RAD21 | Double-strand-break repair protein rad21 homolog. (631 aa) |
| | CTDP1 | RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (929 aa) |
| | CEP95 | Centrosomal protein 95. (819 aa) |
| | KATNA1 | Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal p [...] (493 aa) |
| | SPDL1 | Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. (605 aa) |
| | CEP85 | Centrosomal protein 85. (767 aa) |
| | VPS4A | Uncharacterized protein; Belongs to the AAA ATPase family. (518 aa) |
| | TPX2 | TPX2 microtubule nucleation factor. (747 aa) |
| | PLK1 | Serine/threonine-protein kinase PLK. (601 aa) |
| | UXT | Ubiquitously expressed prefoldin like chaperone. (168 aa) |
| | STAG2 | Cohesin subunit SA-2 isoform a. (1268 aa) |
| | RAE1 | mRNA export factor; Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. (368 aa) |
| | BOD1L1 | Biorientation of chromosomes in cell division protein 1-like 1. (2994 aa) |
| | CTNNB1 | Catenin beta 1. (808 aa) |
| | RMDN1 | Regulator of microtubule dynamics 1. (338 aa) |
| | FAM110A | Family with sequence similarity 110 member A. (295 aa) |
| | NDE1 | NudE neurodevelopment protein 1. (346 aa) |
| | KIF2A | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (744 aa) |
| | MAPRE1 | Microtubule associated protein RP/EB family member 1. (333 aa) |
| | CCDC155 | Coiled-coil domain containing 155. (815 aa) |
| | CKAP5 | Cytoskeleton associated protein 5. (2076 aa) |
| | LATS1 | Large tumor suppressor kinase 1. (1146 aa) |
| | MISP | Mitotic interactor and substrate of PLK1 isoform X1. (650 aa) |
| | A0A287AMB0_PIG | TCTP domain-containing protein; Belongs to the TCTP family. (186 aa) |
| | TOPORS | TOP1 binding arginine/serine rich protein. (1049 aa) |
| | KNTC1 | Kinetochore associated 1. (2207 aa) |
| | A0A287ANW8_PIG | Uncharacterized protein; Belongs to the calmodulin family. (85 aa) |
| | EFHC1 | EF-hand domain containing 1. (665 aa) |
| | CEP44 | Centrosomal protein of 44 kDa isoform X2. (385 aa) |
| | AURKC | Aurora kinase C isoform 1; Belongs to the protein kinase superfamily. (297 aa) |
| | A0A287AUC1_PIG | EF-hand domain-containing protein; Belongs to the calmodulin family. (87 aa) |
| | CALM1 | Uncharacterized protein; Belongs to the calmodulin family. (155 aa) |
| | UBXN2B | UBX domain protein 2B. (369 aa) |
| | NUP62 | Nucleoporin 62. (478 aa) |
| | CEP19 | Centrosomal protein of 19 kDa isoform X3. (163 aa) |
| | GPSM2 | G-protein-signaling modulator 2 isoform X1. (680 aa) |
| | CEP89 | Centrosomal protein of 89 kDa isoform X1. (819 aa) |
| | RMDN2 | Regulator of microtubule dynamics 2. (569 aa) |
| | CETN1 | Centrin 1. (168 aa) |
| | NUP62CL | Nucleoporin 62 C-terminal like. (183 aa) |
| | TUBGCP5 | Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family. (1061 aa) |
| | CEP128 | Centrosomal protein 128. (1142 aa) |
| | GIT1 | GIT ArfGAP 1. (761 aa) |
| | UNC119 | Protein unc-119 homolog A isoform a. (240 aa) |
| | HSF1 | Heat shock transcription factor 1. (590 aa) |
| | CDC14B | Uncharacterized protein. (542 aa) |
| | RAB11A | Ras-related protein Rab-11A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial c [...] (216 aa) |
| | NEK6 | Serine/threonine-protein kinase Nek6; Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase- anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence [...] (402 aa) |
| | BEX4 | Brain expressed X-linked 4. (121 aa) |
| | AURKA | Aurora kinase A; Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase. Required for initial activation [...] (408 aa) |
| | TNKS | Poly [ADP-ribose] polymerase. (1327 aa) |
| | CUL3 | Cullin 3; Belongs to the cullin family. (773 aa) |
| | MAD1L1 | Mitotic arrest deficient 1 like 1. (737 aa) |
| | FBF1 | Fas binding factor 1. (1129 aa) |
| | ASPM | Abnormal spindle microtubule assembly. (2961 aa) |
| | IK | IK cytokine. (554 aa) |
| | A0A287AFW9_PIG | Protein kinase domain-containing protein. (377 aa) |
| | PKP4 | Plakophilin 4. (1234 aa) |
| | DYNC1LI1 | Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (524 aa) |
| | NUBP2 | Cytosolic Fe-S cluster assembly factor NUBP2; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily. (325 aa) |
| | BCCIP | BRCA2 and CDKN1A interacting protein. (327 aa) |
| | WDR73 | WD repeat domain 73. (370 aa) |
| | A0A5G2R7H0_PIG | Vps4_C domain-containing protein. (184 aa) |
| | EMD | LEM domain-containing protein. (400 aa) |
| | A0A5G2RD80_PIG | Uncharacterized protein. (632 aa) |
| | KATNAL2 | Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. (538 aa) |
| | SPAST | Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] (615 aa) |
| | CALM3 | Uncharacterized protein; Belongs to the calmodulin family. (214 aa) |
| | NEK2 | NIMA related kinase 2. (404 aa) |
| | BRCC3 | BRCA1/BRCA2-containing complex subunit 3. (316 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (576 aa) |
| | TUBGCP4 | Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family. (667 aa) |
| | AAAS | Aladin WD repeat nucleoporin. (554 aa) |
| | KATNB1 | Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Micr [...] (690 aa) |
| | KLHL21 | Kelch like family member 21. (598 aa) |
| | FAM83D | Family with sequence similarity 83 member D. (583 aa) |
| | AURKB | Aurora kinase B; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of [...] (443 aa) |
| | NEDD1 | NEDD1 gamma-tubulin ring complex targeting factor. (654 aa) |
| | TUBGCP2 | Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family. (905 aa) |
