STRINGSTRING
PAN3 PAN3 CNOT6L CNOT6L SMG5 SMG5 CNOT3 CNOT3 RC3H1 RC3H1 PAN2 PAN2 CNOT7 CNOT7 DHX34 DHX34 UPF1 UPF1 TENT2 TENT2 EXOSC9 EXOSC9 AGO1 AGO1 XRN2 XRN2 PARN PARN LSM7 LSM7 MAGOH MAGOH EXOSC10 EXOSC10 HELZ2 HELZ2 EXOSC5 EXOSC5 EDC4 EDC4 EXOSC6 EXOSC6 EDC3 EDC3 SKIV2L SKIV2L NBAS NBAS EIF3E EIF3E EXOSC4 EXOSC4 EXOSC3 EXOSC3 ZCCHC7 ZCCHC7 DXO DXO MRTO4 MRTO4 SAMD4B SAMD4B UPF2 UPF2 PABPC1 PABPC1 NOCT NOCT SMG8 SMG8 SMG7 SMG7 CNOT1 CNOT1 THRAP3 THRAP3 RBM8A RBM8A DCP1A DCP1A EXOSC2 EXOSC2 SAMD4A SAMD4A POLR2G POLR2G ZFP36L2 ZFP36L2 XRN1 XRN1 SWT1 SWT1 CNOT8 CNOT8 NCBP1 NCBP1 LSM4 LSM4 CNOT6 CNOT6 LRRC27 LRRC27 EXOSC8 EXOSC8 DCP1B DCP1B ZFP36 ZFP36 PABPN1L PABPN1L SMG6 SMG6 CASC3 CASC3 EIF4A3 EIF4A3 PELO PELO DCPS DCPS ATM ATM ETF1 ETF1 DCP2 DCP2 UPF3B UPF3B PDE12 PDE12 EXOSC7 EXOSC7 ZFP36L1 ZFP36L1 CSDE1 CSDE1 SSB SSB RC3H2 RC3H2 DDX5 DDX5 DIS3L2 DIS3L2 CTIF CTIF ZC3H12A ZC3H12A TTC37 TTC37 PYM1 PYM1 UPF3A UPF3A SMG1 SMG1 SMG9 SMG9 CNOT2 CNOT2 LOC110258923 LOC110258923 LSM1 LSM1 PATL1 PATL1 MTPAP MTPAP
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PAN3PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (906 aa)
CNOT6LCCR4-NOT transcription complex subunit 6 like. (651 aa)
SMG5SMG5 nonsense mediated mRNA decay factor. (1016 aa)
CNOT3CCR4-NOT transcription complex subunit 3. (774 aa)
RC3H1Ring finger and CCCH-type domains 1. (1132 aa)
PAN2PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1198 aa)
CNOT7CCR4-NOT transcription complex subunit 7 isoform 1. (285 aa)
DHX34DExH-box helicase 34. (1098 aa)
UPF1UPF1 RNA helicase and ATPase. (1127 aa)
TENT2Poly(A) RNA polymerase GLD2 isoform X3. (484 aa)
EXOSC9Exosome component 9. (455 aa)
AGO1Argonaute RISC component 1; Belongs to the argonaute family. (1168 aa)
XRN25'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (930 aa)
PARNPoly(A)-specific ribonuclease. (715 aa)
LSM7LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated. (150 aa)
MAGOHMago homolog, exon junction complex subunit. (146 aa)
EXOSC10Exosome component 10. (869 aa)
HELZ2Helicase with zinc finger 2. (2902 aa)
EXOSC5Exosome component 5. (299 aa)
EDC4Enhancer of mRNA decapping 4. (1402 aa)
EXOSC6Exosome component 6. (272 aa)
EDC3Enhancer of mRNA decapping 3. (508 aa)
SKIV2LSki2 like RNA helicase. (1246 aa)
NBASNeuroblastoma amplified sequence. (2318 aa)
EIF3EEukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (445 aa)
EXOSC4Exosome complex component RRP41. (245 aa)
EXOSC3Exosome complex component RRP40 isoform 1. (275 aa)
ZCCHC7Zinc finger CCHC-type containing 7. (545 aa)
DXODecapping exoribonuclease. (395 aa)
MRTO4Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (272 aa)
SAMD4BSterile alpha motif domain containing 4B. (827 aa)
UPF2UPF2 regulator of nonsense mediated mRNA decay. (1270 aa)
PABPC1Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (636 aa)
NOCTNocturnin. (427 aa)
SMG8Uncharacterized protein. (993 aa)
SMG7SMG7 nonsense mediated mRNA decay factor. (1170 aa)
CNOT1CCR4-NOT transcription complex subunit 1. (2343 aa)
THRAP3Thyroid hormone receptor-associated protein 3 isoform 1. (958 aa)
RBM8ARNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (174 aa)
DCP1AmRNA-decapping enzyme 1A; Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1; Belongs to the DCP1 family. (580 aa)
EXOSC2Exosome component 2. (271 aa)
SAMD4ASterile alpha motif domain containing 4A. (718 aa)
POLR2GRNA polymerase II subunit G. (231 aa)
ZFP36L2ZFP36 ring finger protein like 2. (564 aa)
XRN15'-3' exoribonuclease 1. (1703 aa)
SWT1SWT1 RNA endoribonuclease homolog. (900 aa)
CNOT8CCR4-NOT transcription complex subunit 8. (312 aa)
NCBP1Nuclear cap binding protein subunit 1. (1117 aa)
LSM4U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (234 aa)
CNOT6CCR4-NOT transcription complex subunit 6. (590 aa)
LRRC27Leucine rich repeat containing 27. (557 aa)
EXOSC8Exosome component 8. (281 aa)
DCP1BDecapping mRNA 1B. (559 aa)
ZFP36Uncharacterized protein. (372 aa)
PABPN1LPoly(A) binding protein nuclear 1 like, cytoplasmic. (282 aa)
SMG6SMG6 nonsense mediated mRNA decay factor. (1412 aa)
CASC3CASC3 exon junction complex subunit. (633 aa)
EIF4A3Eukaryotic initiation factor 4A-III, N-terminally processed; ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expr [...] (488 aa)
PELOProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (384 aa)
DCPSm7GpppX diphosphatase; Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7- methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not h [...] (337 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...] (3057 aa)
ETF1Eukaryotic peptide chain release factor subunit 1 isoform 1. (437 aa)
DCP2Decapping mRNA 2. (478 aa)
UPF3BUPF3B regulator of nonsense mediated mRNA decay. (483 aa)
PDE122',5'-phosphodiesterase 12 isoform 1. (609 aa)
EXOSC7Uncharacterized protein. (349 aa)
ZFP36L1ZFP36 ring finger protein like 1. (348 aa)
CSDE1Cold shock domain containing E1. (851 aa)
SSBSmall RNA binding exonuclease protection factor La. (401 aa)
RC3H2Ring finger and CCCH-type domains 2. (1192 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (617 aa)
DIS3L2DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] (914 aa)
CTIFCap binding complex dependent translation initiation factor. (608 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (582 aa)
TTC37Tetratricopeptide repeat protein 37 isoform X1. (1563 aa)
PYM1PYM homolog 1, exon junction complex associated factor. (266 aa)
UPF3AUPF3A regulator of nonsense mediated mRNA decay. (502 aa)
SMG1SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3646 aa)
SMG9SMG9 nonsense mediated mRNA decay factor. (542 aa)
CNOT2NOT2_3_5 domain-containing protein. (578 aa)
LOC110258923Uncharacterized protein. (982 aa)
LSM1Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity). (302 aa)
PATL1PAT1 homolog 1, processing body mRNA decay factor. (786 aa)
MTPAPPoly(A) RNA polymerase, mitochondrial. (598 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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