STRINGSTRING
PAM16 PAM16 EXT1 EXT1 BMP4 BMP4 DUOX2 DUOX2 ASF1A ASF1A FGR FGR EPHA2 EPHA2 GPLD1 GPLD1 NAB2 NAB2 PLXNB1 PLXNB1 WWTR1 WWTR1 PHEX PHEX LRP5 LRP5 ADAR ADAR AMELX AMELX FGF9 FGF9 ALPL ALPL CALCR CALCR ATF4 ATF4 GLI1 GLI1 LTBP3 LTBP3 HAND2 HAND2 IGF2 IGF2 TBC1D31 TBC1D31 BMP6 BMP6 EBP EBP TNN TNN FGF2 FGF2 AXIN2 AXIN2 PDLIM7 PDLIM7 DBN1 DBN1 MSX2 MSX2 NOG NOG IFITM5 IFITM5 SP7 SP7 FBXL15 FBXL15 NPR2 NPR2 RASSF2 RASSF2 SCX SCX HIF1A HIF1A SNAI1 SNAI1 CCN4 CCN4 MMP9 MMP9 FHL2 FHL2 A0A287AXH2_PIG A0A287AXH2_PIG SMPD3 SMPD3 FSTL3 FSTL3 CSGALNACT1 CSGALNACT1 WNT3 WNT3 CBS CBS RHOA RHOA SOST SOST PEX7 PEX7 PTHLH PTHLH MMP16 MMP16 THBS3 THBS3 DLX5 DLX5 FZD1 FZD1 MEF2D MEF2D CLEC3B CLEC3B RUNX1 RUNX1 CLEC3A CLEC3A IMPAD1 IMPAD1 CLEC11A CLEC11A MYOC MYOC PTN PTN BMPR1A BMPR1A ENPP1 ENPP1 UCMA UCMA H3F3A H3F3A SIRT7 SIRT7 SNAI2 SNAI2 CCN2 CCN2 ZMPSTE24 ZMPSTE24 ADAMTS12 ADAMTS12 SBNO2 SBNO2 CCDC154 CCDC154 CLEC5A CLEC5A JUNB JUNB IGFBP5 IGFBP5 MESD MESD BMPR1B BMPR1B CYP27B1 CYP27B1 HSD17B4 HSD17B4 MMP14 MMP14 GATA1 GATA1 BMP2 BMP2 NPPC NPPC WNT3A WNT3A SHOX2 SHOX2 I3L7W9_PIG I3L7W9_PIG IFT80 IFT80 TAPT1 TAPT1 WNT11 WNT11 GIT1 GIT1 NF1 NF1 MAP2K6 MAP2K6 SOX9 SOX9 LOC100521680 LOC100521680 ANKH ANKH GLI3 GLI3 SNX10 SNX10 HOXA2 HOXA2 SMO SMO ATP6V0A4 ATP6V0A4 SHH SHH IHH IHH SP3 SP3 COL1A2 COL1A2 MMP13 MMP13 SLC26A2 SLC26A2 PPARGC1B PPARGC1B LOX LOX MEF2C MEF2C COMP COMP PTH PTH LGR4 LGR4 EXT2 EXT2 MEN1 MEN1 TCIRG1 TCIRG1 COL2A1 COL2A1 TMEM38B TMEM38B CHRDL2 CHRDL2 BMPR2 BMPR2 CBFB CBFB PHOSPHO2 PHOSPHO2 TWSG1 TWSG1 WWOX WWOX CCN1 CCN1 COL1A1 COL1A1 MYF5 MYF5 ACHE ACHE RUNX3 RUNX3 MGP MGP ERCC2 ERCC2 SOX8 SOX8 A0A286ZTM7_PIG A0A286ZTM7_PIG TRAF6 TRAF6 LEF1 LEF1 SMAD5 SMAD5 SMAD1 SMAD1 MAPK11 MAPK11 CTNNB1 CTNNB1 TGFB3 TGFB3 TGFB1 TGFB1 ALOX15 ALOX15 GPC3 GPC3 EIF2AK3 EIF2AK3 IBSP IBSP SEMA4D SEMA4D FZD9 FZD9 LTF LTF SATB2 SATB2 DHX36 DHX36 FIGNL1 FIGNL1 BMP3 BMP3 DCHS1 DCHS1 FGF18 FGF18 TP53INP2 TP53INP2 GNAS GNAS TNFRSF11A TNFRSF11A SFRP1 SFRP1 DHH DHH WNT10B WNT10B CTHRC1 CTHRC1 KLF10 KLF10 BGLAP BGLAP LOC100517735 LOC100517735 SLC24A3 SLC24A3 CYP24A1 CYP24A1 SBDS SBDS ASPN ASPN ATP6V1B1 ATP6V1B1 PKDCC PKDCC F1RWC9_PIG F1RWC9_PIG SPP1 SPP1 DMP1 DMP1 TNFSF11 TNFSF11 MN1 MN1 GDF2 GDF2 GDF10 GDF10 RUNX2 RUNX2 LIMD1 LIMD1 COL13A1 COL13A1 HDAC4 HDAC4 SMAD3 SMAD3 MMP2 MMP2 PTH1R PTH1R PHOSPHO1 PHOSPHO1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PAM16Presequence translocase associated motor 16. (156 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
DUOX2Dual oxidase 2; Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. (1539 aa)
ASF1AAnti-silencing function 1A histone chaperone. (204 aa)
FGRTyrosine-protein kinase. (537 aa)
EPHA2Ephrin type-A receptor 2 isoform 1. (975 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (906 aa)
NAB2NGFI-A binding protein 2. (525 aa)
PLXNB1Plexin B1. (2133 aa)
WWTR1WW domain containing transcription regulator 1. (398 aa)
PHEXPhosphate-regulating neutral endopeptidase isoform 1. (749 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa)
ADARAdenosine deaminase RNA specific. (1169 aa)
AMELXUncharacterized protein. (203 aa)
FGF9Fibroblast growth factor 9; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors (By similarity). (228 aa)
ALPLAlkaline phosphatase. (834 aa)
CALCRCalcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. The receptor can also couple to an additional signaling pathway via a pertussis toxin-sensitive g protein in isolated osteoclasts and in LLC-PK1 cells; Belongs to the G-protein coupled receptor 2 family. (490 aa)
ATF4Activating transcription factor 4. (329 aa)
GLI1Zinc finger protein GLI1 isoform X1. (1106 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1332 aa)
HAND2Heart-and neural crest derivatives-expressed protein 2. (217 aa)
IGF2Insulin-like growth factor II; The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is r [...] (583 aa)
TBC1D31TBC1 domain family member 31. (1066 aa)
BMP6TGF_BETA_2 domain-containing protein. (537 aa)
EBPEmopamil binding protein (Sterol isomerase). (230 aa)
TNNTenascin N. (1472 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (316 aa)
AXIN2Axin-2. (843 aa)
PDLIM7PDZ and LIM domain 7. (515 aa)
DBN1Drebrin 1. (857 aa)
MSX2Homeobox protein MSX-2. (267 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
IFITM5Interferon induced transmembrane protein 5. (133 aa)
SP7Sp7 transcription factor. (432 aa)
FBXL15F-box and leucine rich repeat protein 15. (371 aa)
NPR2Guanylate cyclase. (1094 aa)
RASSF2Ras association domain-containing protein 2 isoform X2. (326 aa)
SCXBasic helix-loop-helix transcription factor scleraxis. (310 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform 1. (824 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
CCN4WNT1-inducible-signaling pathway protein 1 isoform X1. (371 aa)
MMP9Matrix metalloproteinase-9. (708 aa)
FHL2Four and a half LIM domains 2. (333 aa)
A0A287AXH2_PIGUncharacterized protein. (284 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (656 aa)
FSTL3Follistatin-related protein 3. (262 aa)
CSGALNACT1Hexosyltransferase. (525 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (453 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (611 aa)
RHOATransforming protein RhoA isoform 1. (193 aa)
SOSTSclerostin. (212 aa)
PEX7Peroxisomal biogenesis factor 7. (308 aa)
PTHLHParathyroid hormone like hormone. (209 aa)
MMP16Matrix metalloproteinase-16. (607 aa)
THBS3Thrombospondin-3 isoform 1. (973 aa)
DLX5Homeobox protein DLX-5. (290 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (564 aa)
MEF2DMyocyte enhancer factor 2D. (531 aa)
CLEC3BC-type lectin domain family 3 member B. (202 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
CLEC3AC-type lectin domain family 3 member A. (196 aa)
IMPAD1Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase; Exhibits 3'-nucleotidase activity toward adenosine 3',5'- bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate. May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, [...] (359 aa)
CLEC11AC-type lectin domain containing 11A. (357 aa)
MYOCMyocilin. (489 aa)
PTNPleiotrophin; Secreted growth factor that mediates its signal through cell- surface proteoglycan and non-proteoglycan receptors. Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups. Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone (By similarity). Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation (By similarity). Binds PTPRZ1, leading to neutralization of the negative char [...] (215 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (878 aa)
UCMAUpper zone of growth plate and cartilage matrix associated. (166 aa)
H3F3AH3 histone, family 3A. (136 aa)
SIRT7Sirtuin 7. (447 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
CCN2CCN family member 2; Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation- dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity). (354 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
ADAMTS12ADAM metallopeptidase with thrombospondin type 1 motif 12. (1598 aa)
SBNO2Strawberry notch homolog 2. (1314 aa)
CCDC154Coiled-coil domain containing 154. (524 aa)
CLEC5AC-type lectin domain family 5 member A; Functions as a positive regulator of osteoclastogenesis (By similarity). Cell surface receptor that signals via TYROBP. Regulates inflammatory responses (By similarity). (185 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
IGFBP5Insulin-like growth factor-binding protein 5; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. (271 aa)
MESDMesoderm development LRP chaperone. (232 aa)
BMPR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (500 aa)
HSD17B4Peroxisomal multifunctional enzyme type 2 isoform 2. (737 aa)
MMP14Matrix metalloproteinase-14; Endopeptidase that degrades various components of the extracellular matrix, such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which i [...] (606 aa)
GATA1Erythroid transcription factor. (412 aa)
BMP2Bone morphogenetic protein 2 preproprotein. (395 aa)
NPPCC-type natriuretic peptide; Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity). (126 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
SHOX2Short stature homeobox 2. (321 aa)
I3L7W9_PIGUncharacterized protein. (373 aa)
IFT80Intraflagellar transport 80. (767 aa)
TAPT1Transmembrane anterior posterior transformation 1. (779 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (536 aa)
GIT1GIT ArfGAP 1. (761 aa)
NF1Neurofibromin 1. (2847 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (339 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
LOC100521680Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa)
ANKHANKH inorganic pyrophosphate transport regulator. (494 aa)
GLI3GLI family zinc finger 3. (1586 aa)
SNX10Sorting nexin-10 isoform 1. (200 aa)
HOXA2Homeobox protein Hox-A2. (380 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (839 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (454 aa)
SP3Sp3 transcription factor. (789 aa)
COL1A2Fibrillar collagen NC1 domain-containing protein. (1135 aa)
MMP13Matrix metallopeptidase 13. (470 aa)
SLC26A2Sulfate transporter; Sulfate transporter. May play a role in endochondral bone formation; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (739 aa)
PPARGC1BPeroxisome proliferator-activated receptor gamma coactivator 1-beta isoform 1. (1028 aa)
LOXProtein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity); Belongs to the lysyl oxidase family. (419 aa)
MEF2CMyocyte-specific enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex [...] (483 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D- glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity). (115 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4 isoform 1. (951 aa)
EXT2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (688 aa)
MEN1Menin 1. (704 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (862 aa)
COL2A1Collagen type II alpha 1 chain. (1486 aa)
TMEM38BTrimeric intracellular cation channel type B. (290 aa)
CHRDL2Chordin like 2. (452 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1085 aa)
CBFBCore-binding factor subunit beta. (204 aa)
PHOSPHO2Pyridoxal phosphate phosphatase PHOSPHO2. (241 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (291 aa)
WWOXWW domain containing oxidoreductase. (414 aa)
CCN1Cellular communication network factor 1. (382 aa)
COL1A1Collagen type I alpha 1 chain. (1477 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (253 aa)
ACHEAcetylcholinesterase (Cartwright blood group); Belongs to the type-B carboxylesterase/lipase family. (765 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (437 aa)
MGPMatrix Gla protein; Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation. (127 aa)
ERCC2General transcription and DNA repair factor IIH helicase subunit XPD isoform 1. (763 aa)
SOX8SRY-box transcription factor 8. (460 aa)
A0A286ZTM7_PIGHistone H3; Belongs to the histone H3 family. (136 aa)
TRAF6TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (541 aa)
LEF1Lymphoid enhancer binding factor 1. (429 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
CTNNB1Catenin beta 1. (808 aa)
TGFB3Transforming growth factor beta-3 proprotein; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi appa [...] (456 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
ALOX15Arachidonate 15-lipoxygenase; Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12- HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the o [...] (786 aa)
GPC3Glypican-3 isoform 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (579 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1095 aa)
IBSPBone sialoprotein 2; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment. (316 aa)
SEMA4DSemaphorin-4D isoform X1; Belongs to the semaphorin family. (865 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
LTFLactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites. (704 aa)
SATB2DNA-binding protein SATB. (733 aa)
DHX36DEAH (Asp-Glu-Ala-His) box polypeptide 36 tv1. (1012 aa)
FIGNL1Fidgetin-like protein 1 isoform 1; Belongs to the AAA ATPase family. (675 aa)
BMP3TGF_BETA_2 domain-containing protein. (719 aa)
DCHS1Dachsous cadherin-related 1. (3294 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
TP53INP2Tumor protein p53 inducible nuclear protein 2. (209 aa)
GNASGuanine nucleotide-binding protein G(s) subunit alpha; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2. (1045 aa)
TNFRSF11ATNF receptor superfamily member 11a. (629 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
CTHRC1Collagen triple helix repeat containing 1. (244 aa)
KLF10Kruppel-like factor 10. (480 aa)
BGLAPOsteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. (100 aa)
LOC100517735Hexosyltransferase. (384 aa)
SLC24A3Solute carrier family 24 member 3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (743 aa)
CYP24A125-hydroxyvitamin D3-24-hydroxylase; Belongs to the cytochrome P450 family. (514 aa)
SBDSRibosome maturation protein SBDS. (250 aa)
ASPNAsporin. (370 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (395 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (493 aa)
F1RWC9_PIGHistone domain-containing protein. (142 aa)
SPP1Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. (303 aa)
DMP1Dentin matrix acidic phosphoprotein 1. (531 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (319 aa)
MN1MN1 proto-oncogene, transcriptional regulator. (1275 aa)
GDF2Growth differentiation factor 2. (427 aa)
GDF10Growth differentiation factor 10. (480 aa)
RUNX2Runt-related transcription factor 2 isoform a. (625 aa)
LIMD1LIM domain-containing protein 1. (671 aa)
COL13A1Collagen type XIII alpha 1 chain. (726 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1160 aa)
SMAD3Mothers against decapentaplegic homolog. (434 aa)
MMP2Uncharacterized protein. (610 aa)
PTH1RParathyroid hormone/parathyroid hormone-related peptide receptor; Receptor for parathyroid hormone and for parathyroid hormone- related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 2 family. (641 aa)
PHOSPHO1Uncharacterized protein. (465 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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