STRINGSTRING
WNT10B WNT10B DHH DHH EPHA2 EPHA2 ASF1A ASF1A BMP4 BMP4 CTHRC1 CTHRC1 BGLAP BGLAP CYP24A1 CYP24A1 F1RWC9_PIG F1RWC9_PIG SPP1 SPP1 GDF2 GDF2 GDF10 GDF10 LIMD1 LIMD1 WWTR1 WWTR1 LRP5 LRP5 MEN1 MEN1 LGR4 LGR4 MEF2C MEF2C LOX LOX IHH IHH SHH SHH SMO SMO HOXA2 HOXA2 GLI3 GLI3 LOC100521680 LOC100521680 MAP2K6 MAP2K6 NF1 NF1 WNT11 WNT11 IFT80 IFT80 I3L7W9_PIG I3L7W9_PIG SHOX2 SHOX2 WNT3A WNT3A HSD17B4 HSD17B4 BMPR1B BMPR1B IGFBP5 IGFBP5 JUNB JUNB CLEC5A CLEC5A SATB2 SATB2 FIGNL1 FIGNL1 BMP3 BMP3 TP53INP2 TP53INP2 SFRP1 SFRP1 CTNNB1 CTNNB1 MAPK11 MAPK11 SMAD1 SMAD1 SMAD5 SMAD5 LEF1 LEF1 A0A286ZTM7_PIG A0A286ZTM7_PIG SOX8 SOX8 BMP2 BMP2 SNAI2 SNAI2 SIRT7 SIRT7 H3F3A H3F3A UCMA UCMA BMPR1A BMPR1A MYOC MYOC MEF2D MEF2D FZD1 FZD1 DLX5 DLX5 PTHLH PTHLH WNT3 WNT3 FHL2 FHL2 CCN4 CCN4 SNAI1 SNAI1 SP7 SP7 NOG NOG MSX2 MSX2 AXIN2 AXIN2 FGF2 FGF2 TNN TNN BMP6 BMP6 HAND2 HAND2 GLI1 GLI1 FGF9 FGF9 AMELX AMELX ADAR ADAR ACHE ACHE COL1A1 COL1A1 CCN1 CCN1 WWOX WWOX RUNX2 RUNX2 BMPR2 BMPR2 CBFB CBFB PTH1R PTH1R SMAD3 SMAD3 HDAC4 HDAC4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
EPHA2Ephrin type-A receptor 2 isoform 1. (975 aa)
ASF1AAnti-silencing function 1A histone chaperone. (204 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
CTHRC1Collagen triple helix repeat containing 1. (244 aa)
BGLAPOsteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. (100 aa)
CYP24A125-hydroxyvitamin D3-24-hydroxylase; Belongs to the cytochrome P450 family. (514 aa)
F1RWC9_PIGHistone domain-containing protein. (142 aa)
SPP1Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. (303 aa)
GDF2Growth differentiation factor 2. (427 aa)
GDF10Growth differentiation factor 10. (480 aa)
LIMD1LIM domain-containing protein 1. (671 aa)
WWTR1WW domain containing transcription regulator 1. (398 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa)
MEN1Menin 1. (704 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4 isoform 1. (951 aa)
MEF2CMyocyte-specific enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex [...] (483 aa)
LOXProtein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity); Belongs to the lysyl oxidase family. (419 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (454 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
HOXA2Homeobox protein Hox-A2. (380 aa)
GLI3GLI family zinc finger 3. (1586 aa)
LOC100521680Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (339 aa)
NF1Neurofibromin 1. (2847 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (536 aa)
IFT80Intraflagellar transport 80. (767 aa)
I3L7W9_PIGUncharacterized protein. (373 aa)
SHOX2Short stature homeobox 2. (321 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
HSD17B4Peroxisomal multifunctional enzyme type 2 isoform 2. (737 aa)
BMPR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
IGFBP5Insulin-like growth factor-binding protein 5; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. (271 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
CLEC5AC-type lectin domain family 5 member A; Functions as a positive regulator of osteoclastogenesis (By similarity). Cell surface receptor that signals via TYROBP. Regulates inflammatory responses (By similarity). (185 aa)
SATB2DNA-binding protein SATB. (733 aa)
FIGNL1Fidgetin-like protein 1 isoform 1; Belongs to the AAA ATPase family. (675 aa)
BMP3TGF_BETA_2 domain-containing protein. (719 aa)
TP53INP2Tumor protein p53 inducible nuclear protein 2. (209 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
CTNNB1Catenin beta 1. (808 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
LEF1Lymphoid enhancer binding factor 1. (429 aa)
A0A286ZTM7_PIGHistone H3; Belongs to the histone H3 family. (136 aa)
SOX8SRY-box transcription factor 8. (460 aa)
BMP2Bone morphogenetic protein 2 preproprotein. (395 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
SIRT7Sirtuin 7. (447 aa)
H3F3AH3 histone, family 3A. (136 aa)
UCMAUpper zone of growth plate and cartilage matrix associated. (166 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
MYOCMyocilin. (489 aa)
MEF2DMyocyte enhancer factor 2D. (531 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (564 aa)
DLX5Homeobox protein DLX-5. (290 aa)
PTHLHParathyroid hormone like hormone. (209 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (453 aa)
FHL2Four and a half LIM domains 2. (333 aa)
CCN4WNT1-inducible-signaling pathway protein 1 isoform X1. (371 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
SP7Sp7 transcription factor. (432 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
MSX2Homeobox protein MSX-2. (267 aa)
AXIN2Axin-2. (843 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (316 aa)
TNNTenascin N. (1472 aa)
BMP6TGF_BETA_2 domain-containing protein. (537 aa)
HAND2Heart-and neural crest derivatives-expressed protein 2. (217 aa)
GLI1Zinc finger protein GLI1 isoform X1. (1106 aa)
FGF9Fibroblast growth factor 9; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors (By similarity). (228 aa)
AMELXUncharacterized protein. (203 aa)
ADARAdenosine deaminase RNA specific. (1169 aa)
ACHEAcetylcholinesterase (Cartwright blood group); Belongs to the type-B carboxylesterase/lipase family. (765 aa)
COL1A1Collagen type I alpha 1 chain. (1477 aa)
CCN1Cellular communication network factor 1. (382 aa)
WWOXWW domain containing oxidoreductase. (414 aa)
RUNX2Runt-related transcription factor 2 isoform a. (625 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1085 aa)
CBFBCore-binding factor subunit beta. (204 aa)
PTH1RParathyroid hormone/parathyroid hormone-related peptide receptor; Receptor for parathyroid hormone and for parathyroid hormone- related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 2 family. (641 aa)
SMAD3Mothers against decapentaplegic homolog. (434 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1160 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.