STRINGSTRING
RELN RELN TBX20 TBX20 EVX1 EVX1 TLX3 TLX3 TEX14 TEX14 CDK5R1 CDK5R1 SDCCAG8 SDCCAG8 CDK5 CDK5 CDK5R2 CDK5R2 DISC1 DISC1 GPM6A GPM6A CCKAR CCKAR ALKBH1 ALKBH1 LOC100625207 LOC100625207 SATB2 SATB2 PLXNA3 PLXNA3 ITGA3 ITGA3 DCX DCX TRIM46 TRIM46 LHX1 LHX1 CTNNB1 CTNNB1 DCLK1 DCLK1 NDE1 NDE1 ARX ARX PAX6 PAX6 COL3A1 COL3A1 CCR4 CCR4 NEO1 NEO1 PEX13 PEX13 FZD3 FZD3 SPOCK1 SPOCK1 PAFAH1B1 PAFAH1B1 CRK CRK BBS1 BBS1 ADGRL3 ADGRL3 LRP12 LRP12 FBXO45 FBXO45 FOXG1 FOXG1 NR4A2 NR4A2 ELP3 ELP3 PLXNA1 PLXNA1 DRGX DRGX NAV1 NAV1 NTRK2 NTRK2 NEUROD4 NEUROD4 AXL AXL DDIT4 DDIT4 GATA3 GATA3 USP9X USP9X PEX5 PEX5 PRKG1 PRKG1 EMX2 EMX2 CELSR2 CELSR2 UNK UNK PEX7 PEX7 RHOA RHOA CHL1 CHL1 RAC3 RAC3 NDN NDN GAS6 GAS6 TUBB2B TUBB2B DAB1 DAB1 DRD2 DRD2 PCM1 PCM1 POU4F1 POU4F1 ASTN2 ASTN2 NDEL1 NDEL1 DCC DCC NRP2 NRP2 NTN1 NTN1 BBS4 BBS4 ASTN1 ASTN1 CELSR1 CELSR1 PHOX2B PHOX2B FEZF1 FEZF1 TUBGCP2 TUBGCP2 KIAA0319L KIAA0319L MDGA2 MDGA2 CNTN2 CNTN2 VEGFA VEGFA NKX2-1 NKX2-1 AUTS2 AUTS2 KIAA0319 KIAA0319 RAPGEF2 RAPGEF2 DCDC2 DCDC2 MDGA1 MDGA1 SRF SRF NR2F2 NR2F2 PSEN1 PSEN1 BAX BAX ACAP3 ACAP3 OLIG3 OLIG3 CEP85L CEP85L FYN FYN TYRO3 TYRO3 BARHL1 BARHL1 BARHL2 BARHL2 SEPTIN14 SEPTIN14 NDNF NDNF ATOH1 ATOH1 NKX6-1 NKX6-1 SH3RF1 SH3RF1 CRKL CRKL ZMIZ1 ZMIZ1 VAX1 VAX1 TOP2B TOP2B CCK CCK POMGNT2 POMGNT2 FEZF2 FEZF2 CDC25C CDC25C KIRREL3 KIRREL3 SEMA3E SEMA3E
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RELNReelin. (3458 aa)
TBX20T-box transcription factor TBX20 isoform 1. (449 aa)
EVX1Even-skipped homeobox 1. (407 aa)
TLX3T cell leukemia homeobox 3. (338 aa)
TEX14Testis expressed 14, intercellular bridge forming factor. (1495 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (315 aa)
SDCCAG8Serologically defined colon cancer antigen 8. (750 aa)
CDK5Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (361 aa)
CDK5R2Cyclin-dependent kinase 5 activator. (365 aa)
DISC1DISC1 scaffold protein. (819 aa)
GPM6AGlycoprotein M6A. (278 aa)
CCKARCholecystokinin A receptor; Belongs to the G-protein coupled receptor 1 family. (428 aa)
ALKBH1AlkB homolog 1, histone H2A dioxygenase. (425 aa)
LOC100625207USP domain-containing protein; Belongs to the peptidase C19 family. (2554 aa)
SATB2DNA-binding protein SATB. (733 aa)
PLXNA3Plexin A3. (1871 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1085 aa)
DCXDoublecortin. (365 aa)
TRIM46Tripartite motif containing 46. (586 aa)
LHX1LIM homeobox 1. (436 aa)
CTNNB1Catenin beta 1. (808 aa)
DCLK1Doublecortin like kinase 1. (730 aa)
NDE1NudE neurodevelopment protein 1. (346 aa)
ARXAristaless related homeobox. (563 aa)
PAX6Paired box 6. (498 aa)
COL3A1Collagen alpha-1(III) chain preproprotein. (1471 aa)
CCR4C-C chemokine receptor type 4 isoform X1; Belongs to the G-protein coupled receptor 1 family. (360 aa)
NEO1Neogenin 1. (1465 aa)
PEX13Peroxisomal biogenesis factor 13. (403 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
SPOCK1SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1. (439 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
CRKCRK proto-oncogene, adaptor protein. (385 aa)
BBS1Bardet-Biedl syndrome 1 protein. (593 aa)
ADGRL3Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family. (1084 aa)
LRP12Low-density lipoprotein receptor-related protein 12 isoform X1. (840 aa)
FBXO45F-box protein 45. (273 aa)
FOXG1Forkhead box G1. (486 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2 isoform X1. (609 aa)
ELP3Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. (638 aa)
PLXNA1Plexin A1. (1909 aa)
DRGXDorsal root ganglia homeobox. (263 aa)
NAV1Neuron navigator 1. (2165 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
NEUROD4Neurogenic differentiation factor. (331 aa)
AXLUncharacterized protein. (871 aa)
DDIT4Uncharacterized protein. (231 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3. (444 aa)
USP9XPutative ubiquitin carboxyl-terminal hydrolase FAF-X isoform X4; Belongs to the peptidase C19 family. (2554 aa)
PEX5Peroxisomal biogenesis factor 5. (660 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
EMX2Empty spiracles homeobox 2. (252 aa)
CELSR2Cadherin EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family. (2917 aa)
UNKUnk zinc finger. (830 aa)
PEX7Peroxisomal biogenesis factor 7. (308 aa)
RHOATransforming protein RhoA isoform 1. (193 aa)
CHL1Cell adhesion molecule L1 like. (1225 aa)
RAC3Rac family small GTPase 3. (192 aa)
NDNNecdin. (325 aa)
GAS6Uncharacterized protein. (682 aa)
TUBB2BTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (465 aa)
DAB1Disabled homolog 1 isoform 1. (553 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (455 aa)
PCM1Pericentriolar material 1. (2184 aa)
POU4F1POU domain protein. (421 aa)
ASTN2Astrotactin 2. (1340 aa)
NDEL1NudE neurodevelopment protein 1 like 1. (394 aa)
DCCDCC netrin 1 receptor. (1423 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (920 aa)
NTN1Netrin-1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (By similarity). Involved in dorsal root ganglion axon projection towards the spinal cord (By similarity). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involve [...] (651 aa)
BBS4Uncharacterized protein. (826 aa)
ASTN1Astrotactin 1. (1269 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (3320 aa)
PHOX2BPaired like homeobox 2B. (314 aa)
FEZF1FEZ family zinc finger 1. (475 aa)
TUBGCP2Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family. (905 aa)
KIAA0319LKIAA0319-like protein. (1048 aa)
MDGA2MAM domain containing glycosylphosphatidylinositol anchor 2. (1025 aa)
CNTN2Contactin 2. (1038 aa)
VEGFAVascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (451 aa)
NKX2-1NK2 homeobox 1. (399 aa)
AUTS2Uncharacterized protein. (1255 aa)
KIAA0319KIAA0319. (1074 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1662 aa)
DCDC2Doublecortin domain containing 2. (474 aa)
MDGA1MAM domain-containing glycosylphosphatidylinositol anchor protein 1 preproprotein. (955 aa)
SRFSerum response factor. (512 aa)
NR2F2Nuclear receptor subfamily 2 group F member 2. (414 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (463 aa)
BAXTrans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family. (480 aa)
ACAP3ArfGAP with coiled-coil, ankyrin repeat and PH domains 3. (833 aa)
OLIG3Oligodendrocyte transcription factor 3. (272 aa)
CEP85LCentrosomal protein 85 like. (791 aa)
FYNTyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] (537 aa)
TYRO3TYRO3 protein tyrosine kinase. (913 aa)
BARHL1BarH like homeobox 1. (327 aa)
BARHL2BarH like homeobox 2. (384 aa)
SEPTIN14Septin 14; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (404 aa)
NDNFNeuron derived neurotrophic factor. (664 aa)
ATOH1Atonal bHLH transcription factor 1. (353 aa)
NKX6-1NK6 homeobox 1. (370 aa)
SH3RF1E3 ubiquitin-protein ligase SH3RF1 isoform X1. (849 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1065 aa)
VAX1Ventral anterior homeobox 1. (333 aa)
TOP2BDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1614 aa)
CCKCholecystokinin-58 desnonopeptide; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. (154 aa)
POMGNT2Protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-). (561 aa)
FEZF2FEZ family zinc finger 2. (503 aa)
CDC25CM-phase inducer phosphatase 3; Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. Directly dephosphorylates CDK1 and activates its kinase activity. When phosphorylated, highly effective in activating G2 cells into prophase (By similarity). (501 aa)
KIRREL3Kirre like nephrin family adhesion molecule 3. (794 aa)
SEMA3ESemaphorin-3E isoform 1; Belongs to the semaphorin family. (775 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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