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ZMPSTE24 ZMPSTE24 UPF2 UPF2 PCK1 PCK1 RPGRIP1L RPGRIP1L CDK5RAP3 CDK5RAP3 CADM1 CADM1 SMAD3 SMAD3 FGL1 FGL1 CUL3 CUL3 CEBPG CEBPG PCK2 PCK2 FRZB FRZB RHBDD3 RHBDD3 BAAT BAAT JARID2 JARID2 CEBPB CEBPB HES1 HES1 NODAL NODAL EZH2 EZH2 XBP1 XBP1 NOTCH1 NOTCH1 HNF4A HNF4A E2F7 E2F7 PKD1 PKD1 CCND1 CCND1 ARF6 ARF6 E2F8 E2F8 GLI1 GLI1 NPHP3 NPHP3 PIK3CA PIK3CA PDX1 PDX1 MAN2A1 MAN2A1 HLX HLX ADA ADA HNF1B HNF1B ACADM ACADM PROX1 PROX1 ATF2 ATF2 DNAAF1 DNAAF1 LSR LSR GATA6 GATA6 CITED2 CITED2 LOC100511607 LOC100511607 LOC100512146 LOC100512146 SEC63 SEC63 ONECUT2 ONECUT2 ONECUT1 ONECUT1 ANXA1 ANXA1 NOTCH2 NOTCH2 SULF2 SULF2 GFER GFER TGFA TGFA PKD2 PKD2 TBX3 TBX3 HNF1A HNF1A SMARCB1 SMARCB1 CCDC39 CCDC39 ZIC3 ZIC3 RELA RELA PRKCSH PRKCSH HGF HGF F1SF13_PIG F1SF13_PIG SP3 SP3 MET MET SOX9 SOX9 MED1 MED1 NF1 NF1 CCDC40 CCDC40 TAF10 TAF10 RB1CC1 RB1CC1 PCSK9 PCSK9 IL6 IL6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
UPF2UPF2 regulator of nonsense mediated mRNA decay. (1270 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (841 aa)
RPGRIP1LProtein fantom isoform X1. (1270 aa)
CDK5RAP3CDK5 regulatory subunit associated protein 3. (513 aa)
CADM1Cell adhesion molecule 1. (473 aa)
SMAD3Mothers against decapentaplegic homolog. (434 aa)
FGL1Fibrinogen like 1. (315 aa)
CUL3Cullin 3; Belongs to the cullin family. (773 aa)
CEBPGCCAAT enhancer binding protein gamma. (164 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (673 aa)
FRZBSecreted frizzled-related protein 3. (325 aa)
RHBDD3Rhomboid domain-containing protein 3. (428 aa)
BAATBile acid-CoA:amino acid N-acyltransferase. (407 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1245 aa)
CEBPBCCAAT/enhancer-binding protein. (346 aa)
HES1Uncharacterized protein. (280 aa)
NODALNodal growth differentiation factor. (316 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (762 aa)
XBP1BZIP domain-containing protein. (378 aa)
NOTCH1Neurogenic locus notch homolog protein 1 preproprotein. (2560 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (505 aa)
E2F7E2F transcription factor 7. (908 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4383 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
ARF6ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling (By similarity). Required for normal completion of mitotic cytokinesis (By similarity). Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers (By similarity). Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension (By similarity). Plays an important role in membrane trafficking, during junctional remodeling and epithelial po [...] (175 aa)
E2F8E2F transcription factor 8. (859 aa)
GLI1Zinc finger protein GLI1 isoform X1. (1106 aa)
NPHP3TPR_REGION domain-containing protein. (1368 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PDX1Homeobox domain-containing protein. (284 aa)
MAN2A1Alpha-mannosidase. (1164 aa)
HLXH2.0 like homeobox. (556 aa)
ADAAdenosine deaminase. (409 aa)
HNF1BHepatocyte nuclear factor 1-beta; Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Binds to the PFC element in the UPA gene. (577 aa)
ACADMMedium-chain specific acyl-CoA dehydrogenase, mitochondrial; Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta-oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). (454 aa)
PROX1Prospero homeobox 1. (737 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
DNAAF1Dynein assembly factor 1, axonemal. (650 aa)
LSRLipolysis stimulated lipoprotein receptor. (598 aa)
GATA6Transcription factor GATA-6; Transcriptional activator that regulates SEMA3C and PLXNA2. May regulate genes that protect epithelial cells from bacterial infection. Involved in gene regulation specifically in the gastric epithelium. Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. (592 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
LOC100511607Uncharacterized protein. (340 aa)
LOC100512146Uncharacterized protein. (358 aa)
SEC63SEC63 homolog, protein translocation regulator. (760 aa)
ONECUT2One cut domain family member. (694 aa)
ONECUT1One cut domain family member. (465 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (346 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform 1 preproprotein. (2471 aa)
SULF2Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (906 aa)
GFERSulfhydryl oxidase. (365 aa)
TGFAProtransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. (160 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (970 aa)
TBX3T-box transcription factor TBX3 isoform 2. (745 aa)
HNF1AHepatocyte nuclear factor 1-alpha isoform 2. (631 aa)
SMARCB1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (385 aa)
CCDC39Coiled-coil domain-containing protein 39. (942 aa)
ZIC3Zic family member 3. (467 aa)
RELATranscription factor p65 isoform 1. (573 aa)
PRKCSHGlucosidase 2 subunit beta isoform X1. (537 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (814 aa)
F1SF13_PIGCobl domain-containing protein. (406 aa)
SP3Sp3 transcription factor. (789 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1381 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1517 aa)
NF1Neurofibromin 1. (2847 aa)
CCDC40Coiled-coil domain containing 40. (986 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (217 aa)
RB1CC1RB1 inducible coiled-coil 1. (1608 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9. (678 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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