STRINGSTRING
CAV1 CAV1 EPHA2 EPHA2 NOX5 NOX5 BMP4 BMP4 TEK TEK NRARP NRARP PROK1 PROK1 SCARB1 SCARB1 CAV2 CAV2 FGF10 FGF10 ERN1 ERN1 NF1 NF1 PROK2 PROK2 TGFBR1 TGFBR1 DLG1 DLG1 LOXL2 LOXL2 BMPR2 BMPR2 BMPER BMPER DLG2 DLG2 VSTM4 VSTM4 APOA1 APOA1 ITGB1BP1 ITGB1BP1 PRKX PRKX THAP1 THAP1 FGF2 FGF2 XBP1 XBP1 A0A287ANG8_PIG A0A287ANG8_PIG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (177 aa)
EPHA2Ephrin type-A receptor 2 isoform 1. (975 aa)
NOX5NADPH oxidase 5. (799 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
TEKTEK receptor tyrosine kinase. (1147 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
PROK1Prokineticin 1. (105 aa)
SCARB1Scavenger receptor class B member 1; Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB- containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. (509 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity); Belongs to the caveolin family. (162 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
ERN1Uncharacterized protein. (1029 aa)
NF1Neurofibromin 1. (2847 aa)
PROK2Prokineticin 2. (129 aa)
TGFBR1TGF-beta receptor type-1; Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinog [...] (560 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (939 aa)
LOXL2Lysyl oxidase like 2. (758 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1085 aa)
BMPERBMP binding endothelial regulator. (699 aa)
DLG2Discs large MAGUK scaffold protein 2. (1012 aa)
VSTM4V-set and transmembrane domain containing 4. (382 aa)
APOA1Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. (279 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (270 aa)
PRKXUncharacterized protein; Belongs to the protein kinase superfamily. (358 aa)
THAP1THAP domain-containing protein 1 isoform 1. (213 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (316 aa)
XBP1BZIP domain-containing protein. (378 aa)
A0A287ANG8_PIGProtein kinase domain-containing protein. (183 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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