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| | BFAR | Bifunctional apoptosis regulator isoform 1. (450 aa) |
| | A2M | Alpha-2-macroglobulin. (1504 aa) |
| | A2ML1 | Alpha-2-macroglobulin like 1. (1457 aa) |
| | VWF | Von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity). (2940 aa) |
| | SLC2A13 | Solute carrier family 2 member 13; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (649 aa) |
| | BAG6 | Large proline-rich protein BAG6; ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endo [...] (1163 aa) |
| | POLG | DNA polymerase gamma, catalytic subunit. (1224 aa) |
| | LONP2 | Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta- oxidation through degradation of the self-processed forms of TYSND1. (852 aa) |
| | CD177 | CD177 molecule. (438 aa) |
| | PARK7 | DJ-1 protein. (189 aa) |
| | PINK1 | PTEN induced kinase 1. (588 aa) |
| | SELENOS | Selenoprotein S; Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination (By similarity). (190 aa) |
| | ADAMTS4 | ADAM metallopeptidase with thrombospondin type 1 motif 4. (872 aa) |
| | ANXA9 | Annexin. (360 aa) |
| | BCL10 | B-cell lymphoma/leukemia 10 isoform 1. (233 aa) |
| | PSAPL1 | Proactivator polypeptide-like 1; May activate the lysosomal degradation of sphingolipids. (518 aa) |
| | MIF | Macrophage migration inhibitory factor; Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (By simi [...] (115 aa) |
| | TYSND1 | Trypsin domain containing 1. (624 aa) |
| | TIMP1 | Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity). (207 aa) |
| | INSL3 | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity); Belongs to the insulin family. (131 aa) |
| | COMP | Cartilage oligomeric matrix protein. (756 aa) |
| | SRI | Sorcin isoform A. (199 aa) |
| | COL1A2 | Fibrillar collagen NC1 domain-containing protein. (1135 aa) |
| | CDK5R1 | Cyclin-dependent kinase 5 activator. (315 aa) |
| | ECM1 | Extracellular matrix protein 1. (559 aa) |
| | CSTB | Cystatin-B; This is an intracellular thiol proteinase inhibitor; Belongs to the cystatin family. (98 aa) |
| | F3 | Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (292 aa) |
| | ELANE | Elastase, neutrophil expressed; Belongs to the peptidase S1 family. (271 aa) |
| | BDKRB2 | B2 bradykinin receptor; Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). (440 aa) |
| | TWNK | Twinkle protein, mitochondrial isoform A. (684 aa) |
| | DVL3 | Segment polarity protein dishevelled homolog DVL-3 isoform X1. (716 aa) |
| | SERPINE1 | Plasminogen activator inhibitor 1; Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase- type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. I [...] (401 aa) |
| | RNF139 | E3 ubiquitin-protein ligase RNF139. (665 aa) |
| | BRCA2 | Tower domain-containing protein. (1163 aa) |
| | ITGA3 | Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1085 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (533 aa) |
| | FLOT1 | Flotillin-1; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. (427 aa) |
| | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1. (850 aa) |
| | FAP | Fibroblast activation protein alpha; Belongs to the peptidase S9B family. (760 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa) |
| | ITGB1 | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (853 aa) |
| | TNFAIP3 | Tumor necrosis factor alpha-induced protein 3 isoform X1. (785 aa) |
| | CTLA4 | Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. (223 aa) |
| | ITGAV | Integrin subunit alpha V; Belongs to the integrin alpha chain family. (1052 aa) |
| | ANXA2 | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. (414 aa) |
| | DERL1 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (251 aa) |
| | COL3A1 | Collagen alpha-1(III) chain preproprotein. (1471 aa) |
| | THAP5 | THAP domain containing 5. (393 aa) |
| | LOC110261265 | NTR domain-containing protein. (239 aa) |
| | SYVN1 | Synoviolin 1. (613 aa) |
| | PSAP | Saposin-B-Val; Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta- galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha- galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. (573 aa) |
| | SART3 | Spliceosome associated factor 3, U4/U6 recycling protein. (972 aa) |
| | LCOR | Ligand dependent nuclear receptor corepressor. (1695 aa) |
| | FBXO45 | F-box protein 45. (273 aa) |
| | TIMP3 | TIMP metallopeptidase inhibitor 3. (211 aa) |
| | CFLAR | CASP8 and FADD-like apoptosis regulator isoform 1; Belongs to the peptidase C14A family. (509 aa) |
| | TRIP4 | Thyroid hormone receptor interactor 4. (649 aa) |
| | NTRK2 | Tyrosine-protein kinase receptor. (838 aa) |
| | AMFR | Autocrine motility factor receptor. (731 aa) |
| | INS | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa) |
| | FLOT2 | Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa) |
| | SERPINB13 | Serpin family B member 13; Belongs to the serpin family. (390 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (414 aa) |
| | RAD23A | RAD23 homolog A, nucleotide excision repair protein. (417 aa) |
| | CHL1 | Cell adhesion molecule L1 like. (1225 aa) |
| | BIN1 | Bridging integrator 1. (588 aa) |
| | SPATA2 | Spermatogenesis-associated protein 2. (520 aa) |
| | ADAMTSL4 | ADAMTS like 4. (1079 aa) |
| | PYCARD | Apoptosis-associated speck-like protein containing a CARD isoform a. (196 aa) |
| | TIMP4 | TIMP metallopeptidase inhibitor 4. (224 aa) |
| | NOL3 | Nucleolar protein 3. (237 aa) |
| | RIOK3 | Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. (519 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (442 aa) |
| | A0A287B8J8_PIG | Uncharacterized protein. (617 aa) |
| | SERPINF2 | Alpha-2-antiplasmin isoform X2; Belongs to the serpin family. (563 aa) |
| | RFFL | Uncharacterized protein. (799 aa) |
| | ADRM1 | Adhesion regulating molecule 1. (423 aa) |
| | FURIN | Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (797 aa) |
| | PZP | Uncharacterized protein. (1416 aa) |
| | PDZD3 | Na(+)/H(+) exchange regulatory cofactor NHE-RF4 isoform 1. (506 aa) |
| | DPP4 | Dipeptidyl peptidase 4 membrane form; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T- cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the mi [...] (833 aa) |
| | MBP | Myelin basic protein; Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity). (295 aa) |
| | PRKN | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (461 aa) |
| | ATP9A | Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1617 aa) |
| | LOC100627067 | Uncharacterized protein. (518 aa) |
| | CLTC | Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1702 aa) |
| | SELL | Selectin L. (399 aa) |
| | COL1A1 | Collagen type I alpha 1 chain. (1477 aa) |
| | KIT | Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (975 aa) |
| | BANK1 | B cell scaffold protein with ankyrin repeats 1. (780 aa) |
| | TIMP2 | Uncharacterized protein. (257 aa) |
| | SERPINC1 | SERPIN domain-containing protein; Belongs to the serpin family. (431 aa) |
| | IL1R1 | Interleukin-1 receptor type 1 isoform 1. (572 aa) |
| | YIPF5 | Protein YIPF. (257 aa) |
| | LDLR | Low-density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. (878 aa) |
| | NFRKB | Nuclear factor related to kappaB binding protein. (1333 aa) |
| | CD28 | IGv domain-containing protein. (222 aa) |
| | CCBE1 | Collagen and calcium binding EGF domains 1. (407 aa) |
| | ITGB3 | Integrin beta; Belongs to the integrin beta chain family. (835 aa) |
| | MARCHF6 | Membrane associated ring-CH-type finger 6. (910 aa) |
| | CHMP3 | Uncharacterized protein. (251 aa) |
