STRINGSTRING
COMP COMP IMPAD1 IMPAD1 SMPD3 SMPD3 ACAN ACAN SFRP2 SFRP2 SULF1 SULF1 SULF2 SULF2 EXT1 EXT1 SERPINH1 SERPINH1 MEX3C MEX3C RARG RARG FGF18 FGF18 BMPR1B BMPR1B ECM1 ECM1 SHOX2 SHOX2 MATN1 MATN1 SOX9 SOX9 BMPR2 BMPR2 HOXA11 HOXA11 RUNX2 RUNX2 CHST11 CHST11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
COMPCartilage oligomeric matrix protein. (756 aa)
IMPAD1Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase; Exhibits 3'-nucleotidase activity toward adenosine 3',5'- bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate. May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, [...] (359 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (656 aa)
ACANAggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. (2434 aa)
SFRP2Uncharacterized protein. (294 aa)
SULF1Sulfatase 1. (1108 aa)
SULF2Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (906 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
SERPINH1SERPIN domain-containing protein; Belongs to the serpin family. (418 aa)
MEX3CRNA-binding E3 ubiquitin-protein ligase MEX3C. (655 aa)
RARGRetinoic acid receptor gamma. (554 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
BMPR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ECM1Extracellular matrix protein 1. (559 aa)
SHOX2Short stature homeobox 2. (321 aa)
MATN1Matrilin 1. (496 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1085 aa)
HOXA11Homeobox protein Hox-A11. (317 aa)
RUNX2Runt-related transcription factor 2 isoform a. (625 aa)
CHST11Carbohydrate sulfotransferase. (352 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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