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| | IFN-ALPHA-8 | Uncharacterized protein. (226 aa) |
| | CSF2RB | Colony stimulating factor 2 receptor beta common subunit. (893 aa) |
| | CRACR2A | Calcium release activated channel regulator 2A. (872 aa) |
| | C2 | Uncharacterized protein; Belongs to the peptidase S1 family. (853 aa) |
| | HLA-DRA | Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (252 aa) |
| | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain. (277 aa) |
| | TAP2 | Uncharacterized protein. (726 aa) |
| | TAP1 | Transporter 1, ATP binding cassette subfamily B member. (718 aa) |
| | SLA-DMB | Major histocompatibility complex, class II, DM beta. (272 aa) |
| | SLA-DOA | Ig-like domain-containing protein; Belongs to the MHC class II family. (360 aa) |
| | DEF6 | Differentially expressed in FDCP 6 homolog. (631 aa) |
| | RAB44 | RAB44, member RAS oncogene family. (984 aa) |
| | IL17A | Interleukin-17A; Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines. Belongs to the IL-17 family. (153 aa) |
| | CTSH | Cathepsin H heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family. (335 aa) |
| | FES | Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa) |
| | CSK | Tyrosine-protein kinase. (474 aa) |
| | ARG2 | Arginase. (354 aa) |
| | EXOSC6 | Exosome component 6. (272 aa) |
| | LOC100515837 | Leukocyte associated immunoglobulin like receptor 1. (280 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa) |
| | FGR | Tyrosine-protein kinase. (537 aa) |
| | C8A | Complement C8 alpha chain. (589 aa) |
| | TRAF3IP2 | TRAF3 interacting protein 2. (574 aa) |
| | FYN | Tyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] (537 aa) |
| | FRK | Tyrosine-protein kinase. (511 aa) |
| | RORA | RAR related orphan receptor A. (530 aa) |
| | IFNE | Interferon epsilon; Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity); Belongs to the alpha/beta interferon family. (193 aa) |
| | IFN-DELTA-1 | Short type I interferon. (170 aa) |
| | IFNB1 | Interferon-beta-1. (186 aa) |
| | CD274 | CD274 molecule. (311 aa) |
| | ANXA1 | Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (346 aa) |
| | EXOSC3 | Exosome complex component RRP40 isoform 1. (275 aa) |
| | MORN5 | Uncharacterized protein. (188 aa) |
| | LYN | Tyrosine-protein kinase. (512 aa) |
| | SLAMF6 | SLAM family member 6. (321 aa) |
| | CTSS | Cathepsin S; Belongs to the peptidase C1 family. (341 aa) |
| | BCL10 | B-cell lymphoma/leukemia 10 isoform 1. (233 aa) |
| | JAG1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1211 aa) |
| | ZP3 | Processed zona pellucida sperm-binding protein 3; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for zona matrix formation. May not have a sperm- binding activity by itself but may increase sperm-binding activity of ZPB. (421 aa) |
| | IL21R | Interleukin 21 receptor. (547 aa) |
| | IL4R | Interleukin-4 receptor subunit alpha; Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 (By similarity). (830 aa) |
| | IL9R | Fibronectin type-III domain-containing protein. (290 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (920 aa) |
| | TXK | Tyrosine-protein kinase. (551 aa) |
| | TEC | Tyrosine-protein kinase. (632 aa) |
| | FGB | Fibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it i [...] (534 aa) |
| | FGA | Fibrinogen alpha chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it [...] (924 aa) |
| | LIG4 | DNA ligase. (910 aa) |
| | TNFSF13B | Tumor necrosis factor superfamily member 13b; Belongs to the tumor necrosis factor family. (233 aa) |
| | P2RX7 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa) |
| | UNG | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (430 aa) |
| | MARCHF8 | E3 ubiquitin-protein ligase MARCH8 isoform X1. (571 aa) |
| | ENTPD7 | Ectonucleoside triphosphate diphosphohydrolase 7; Belongs to the GDA1/CD39 NTPase family. (604 aa) |
| | NFKB2 | Nuclear factor NF-kappa-B p100 subunit isoform X1. (901 aa) |
| | IFNK | Interferon-kappa. (208 aa) |
| | RFTN1 | Raftlin, lipid raft linker 1. (566 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (323 aa) |
| | BCL6 | B-cell lymphoma 6 protein isoform X1. (706 aa) |
| | TFE3 | Transcription factor binding to IGHM enhancer 3. (575 aa) |
| | SH2D1A | SH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1. Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Ca [...] (128 aa) |
| | TCIRG1 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (862 aa) |
| | C3 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates (By similarity). [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. (1661 aa) |
| | MEF2C | Myocyte-specific enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex [...] (483 aa) |
| | CTSC | Cathepsin C; Belongs to the peptidase C1 family. (463 aa) |
| | CD3E | T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...] (267 aa) |
| | LAX1 | Lymphocyte transmembrane adaptor 1. (401 aa) |
| | F1S342_PIG | Uncharacterized protein. (332 aa) |
| | DBNL | Drebrin like. (429 aa) |
| | C9 | MACPF domain-containing protein. (575 aa) |
| | C7 | Complement component C7; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor. Belongs to the complement C6/C7/C8/C9 family. (841 aa) |
| | UNC13D | Unc-13 homolog D. (1090 aa) |
| | CD79B | CD79b molecule. (228 aa) |
| | STAT3 | Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] (772 aa) |
| | TBX21 | Uncharacterized protein. (535 aa) |
| | PHB | Prohibitin. (272 aa) |
| | CD4 | CD4 molecule. (494 aa) |
| | TREX1 | Three prime repair exonuclease 1. (314 aa) |
| | STAT6 | Signal transducer and activator of transcription. (847 aa) |
| | CD40LG | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (261 aa) |
| | ERAP2 | Aminopeptidase. (951 aa) |
| | CX3CR1 | CX3C chemokine receptor 1 isoform a; Belongs to the G-protein coupled receptor 1 family. (356 aa) |
| | CCR6 | C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (376 aa) |
| | FER | Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa) |
| | TRAT1 | T cell receptor associated transmembrane adaptor 1. (181 aa) |
| | BTK | Tyrosine-protein kinase. (659 aa) |
| | IFN-DELTA-6 | Uncharacterized protein. (184 aa) |
| | HAVCR2 | Hepatitis A virus cellular receptor 2. (283 aa) |
| | AIRE | Autoimmune regulator. (559 aa) |
| | CD1.1 | T-cell surface glycoprotein CD1a; Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. (339 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1363 aa) |
| | I3LV48_PIG | Uncharacterized protein. (181 aa) |
| | BMX | Tyrosine-protein kinase. (706 aa) |
| | MASP2 | Uncharacterized protein; Belongs to the peptidase S1 family. (823 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (533 aa) |
| | IL7R | Fibronectin type-III domain-containing protein. (458 aa) |
| | CD3D | T-cell surface glycoprotein CD3 delta chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of [...] (171 aa) |
| | PPP3CB | Serine/threonine-protein phosphatase. (527 aa) |
| | JAK2 | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] (1131 aa) |
| | IFN-DELTA-5 | Interferon-delta-5. (184 aa) |
| | TNFRSF11A | TNF receptor superfamily member 11a. (629 aa) |
| | IL18BP | Interleukin 18 binding protein. (188 aa) |
| | IFN-DELTA-9 | Interferon-delta-9. (184 aa) |
| | FCAMR | Uncharacterized protein. (479 aa) |
| | SRC | Tyrosine-protein kinase. (559 aa) |
| | ALCAM | Activated leukocyte cell adhesion molecule. (619 aa) |
| | TGFB1 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa) |
| | ZAP70 | Tyrosine-protein kinase. (615 aa) |
| | CD247 | T-cell surface glycoprotein CD3 zeta chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of d [...] (168 aa) |
| | K7GSB8_PIG | Ig-like domain-containing protein. (331 aa) |
| | JAK3 | Tyrosine-protein kinase. (1103 aa) |
| | BCL3 | ANK_REP_REGION domain-containing protein. (453 aa) |
| | SLA-DMA | Ig-like domain-containing protein; Belongs to the MHC class II family. (290 aa) |
| | CTLA4 | Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. (223 aa) |
| | BLK | Tyrosine-protein kinase. (501 aa) |
| | A0A286ZKB7_PIG | Ig-like domain-containing protein. (259 aa) |
| | LOC110258710 | C-type lectin domain-containing protein. (212 aa) |
| | JAK1 | Tyrosine-protein kinase. (1154 aa) |
| | CD55 | Uncharacterized protein. (609 aa) |
| | ITK | Tyrosine-protein kinase. (598 aa) |
| | SYK | 40 kDa tyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the recepto [...] (628 aa) |
| | BACH2 | Transcription regulator protein BACH2 isoform X2. (843 aa) |
| | LEF1 | Lymphoid enhancer binding factor 1. (429 aa) |
| | TRAF6 | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (541 aa) |
| | RELB | RELB proto-oncogene, NF-kB subunit. (574 aa) |
| | C1QC | Complement C1q subcomponent subunit C isoform 1. (245 aa) |
| | KLRK1 | NKG2-D type II integral membrane protein; Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-exp [...] (221 aa) |
| | TYK2 | Tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1226 aa) |
| | A0A286ZVL9_PIG | RING-type domain-containing protein. (137 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa) |
| | FGL1 | Fibrinogen like 1. (315 aa) |
| | PTK6 | Tyrosine-protein kinase. (449 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa) |
| | EMP2 | Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa) |
| | CARD9 | Caspase recruitment domain family member 9. (560 aa) |
| | IRF4 | Interferon regulatory factor 4. (451 aa) |
| | CD19 | CD19 molecule. (645 aa) |
| | MYO1G | Myosin IG; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (983 aa) |
| | CD8A | CD8a molecule. (237 aa) |
| | A0A287AAB9_PIG | Ig-like domain-containing protein. (252 aa) |
| | INPP5D | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X1. (1199 aa) |
| | RAB27A | Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. (221 aa) |
| | HPRT1 | Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). (224 aa) |
| | GZMM | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (497 aa) |
| | C8G | Complement C8 gamma chain. (257 aa) |
| | CD46 | Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. May act as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. (381 aa) |
| | CD3G | T-cell surface glycoprotein CD3 gamma chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of [...] (176 aa) |
| | LCK | Tyrosine-protein kinase. (520 aa) |
| | C5 | Complement C5a anaphylatoxin; Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation. (1677 aa) |
| | TRAV3 | T cell receptor alpha variable 3 (gene/pseudogene). (164 aa) |
| | C4BPB | Complement component 4 binding protein beta. (263 aa) |
| | SEMA4A | Semaphorin-4A isoform X2; Belongs to the semaphorin family. (791 aa) |
| | SRMS | Tyrosine-protein kinase. (494 aa) |
| | A0A287ANX9_PIG | Uncharacterized protein. (472 aa) |
| | C8B | MACPF domain-containing protein. (648 aa) |
| | IFN-ALPHA-15 | Uncharacterized protein. (225 aa) |
| | ABL2 | Tyrosine-protein kinase. (1096 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (752 aa) |
| | LOC110260749 | C-type lectin domain family 4 member A isoform 1. (212 aa) |
| | PRF1 | Perforin 1. (555 aa) |
| | TNFRSF21 | TNF receptor superfamily member 21. (813 aa) |
| | FOXP3 | Forkhead box protein P3 isoform a. (475 aa) |
| | A0A287B199_PIG | Ig-like domain-containing protein. (313 aa) |
| | NOTCH1 | Neurogenic locus notch homolog protein 1 preproprotein. (2560 aa) |
| | CD74 | Thyroglobulin type-1 domain-containing protein. (347 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | CD40 | Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). (278 aa) |
| | MATK | Tyrosine-protein kinase. (485 aa) |
| | ABL1 | Tyrosine-protein kinase. (1146 aa) |
| | PRKCD | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (723 aa) |
| | A0A287BCD2_PIG | Uncharacterized protein. (164 aa) |
| | KLHL6 | BTB domain-containing protein. (620 aa) |
| | HMGB1 | High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...] (241 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1891 aa) |
| | FCGR1A | Uncharacterized protein. (362 aa) |
| | SLA-DRB1 | Ig-like domain-containing protein. (307 aa) |
| | THEMIS | Thymocyte selection associated. (640 aa) |
| | KIAA1841 | KIAA1841. (731 aa) |
| | IL18R1 | Interleukin 18 receptor 1. (539 aa) |
| | CD7 | Ig-like domain-containing protein. (206 aa) |
| | EPHB6 | EPH receptor B6. (1006 aa) |
| | C1QA | Complement C1q subcomponent subunit A; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. (266 aa) |
| | LAC_PIG | Ig lambda chain C region. (380 aa) |
| | A0A287BQB1_PIG | zf-C3HC4 domain-containing protein. (282 aa) |
| | JCHAIN | Joining chain of multimeric IgA and IgM. (186 aa) |
| | TMEM98 | Transmembrane protein 98. (226 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa) |
| | A0A287BRG1_PIG | Uncharacterized protein. (210 aa) |
| | HCK | Tyrosine-protein kinase. (527 aa) |
| | CD79A | Ig-like domain-containing protein. (234 aa) |
| | AKIRIN2 | Akirin 2. (213 aa) |
| | SWAP70 | Switching B cell complex subunit SWAP70. (585 aa) |
| | IFN-DELTA-8 | Interferon-delta-8. (167 aa) |
| | LOC100517145 | Uncharacterized protein. (1670 aa) |
| | YES1 | Tyrosine-protein kinase. (553 aa) |
| | C4A | Uncharacterized protein. (1758 aa) |
| | SLA-DQB1 | SLA class II histocompatibility antigen, DQ haplotype C beta chain. (271 aa) |
| | RAG1 | V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1049 aa) |
| | MBL2 | Mannose-binding protein C; Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. According to some authors, it only binds mannose. (239 aa) |
| | C1QB | Complement C1q B chain. (295 aa) |
| | IFN-ALPHA-9 | Interferon-alpha-9. (189 aa) |
| | A0A5G2QNP5_PIG | Uncharacterized protein. (271 aa) |
| | IFNA1 | Uncharacterized protein. (189 aa) |
| | A0A5G2QJW8_PIG | Ig_C17orf99 domain-containing protein. (318 aa) |
| | C1QBP | Mitochondrial complement component 1 Q subcomponent-binding protein. (281 aa) |
| | GPR183 | G-protein coupled receptor 183 isoform X1; Belongs to the G-protein coupled receptor 1 family. (356 aa) |
| | NTN1 | Netrin-1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (By similarity). Involved in dorsal root ganglion axon projection towards the spinal cord (By similarity). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involve [...] (651 aa) |
| | A0A5G2QZT5_PIG | Uncharacterized protein. (178 aa) |
| | IFN-ALPHA-4 | Interferon alpha-1; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (189 aa) |
| | AICDA | Activation induced cytidine deaminase. (224 aa) |
| | IL6R | Interleukin-6 receptor subunit alpha; Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis; Belongs to the type I cytokine receptor family. Type 3 subfamily. (491 aa) |
| | CLEC4G | C-type lectin domain-containing protein. (358 aa) |
| | SLA-DQA1 | SLA class II histocompatibility antigen, DQ haplotype D alpha chain. (255 aa) |
| | ADA | Adenosine deaminase. (409 aa) |
| | LOC100736569 | Uncharacterized protein. (428 aa) |
| | C6 | Uncharacterized protein. (927 aa) |
| | TREM1 | Triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock (By similarity). (252 aa) |
| | HLX | H2.0 like homeobox. (556 aa) |
| | EXO1 | Exonuclease 1. (836 aa) |
| | TSC1 | TSC complex subunit 1. (1166 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (575 aa) |
| | CD81 | Tetraspanin. (258 aa) |
