STRINGSTRING
XCL1 XCL1 CCL25 CCL25 CCL4 CCL4 LGALS3 LGALS3 FLT1 FLT1 ANXA1 ANXA1 CCL11 CCL11 CCL2 CCL2 CCL17 CCL17 I3L9Z6_PIG I3L9Z6_PIG PTPRO PTPRO CCL5 CCL5 CCL20 CCL20 MSMP MSMP CCL24 CCL24 CCL8 CCL8 LOC100516039 LOC100516039 CCL21 CCL21 PDGFB PDGFB CCL14 CCL14 CCL26 CCL26 CCL16 CCL16 CCL1 CCL1 CCL19 CCL19 CCL22 CCL22 TNFSF11 TNFSF11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
XCL1Lymphotactin isoform X1. (110 aa)
CCL25C-C motif chemokine 25; Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 (By similarity); Belongs to the intercrine beta (chemokine CC) family. (220 aa)
CCL4C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. (96 aa)
LGALS3Galectin. (271 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1302 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (346 aa)
CCL11C-C motif chemokine. (97 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (99 aa)
CCL17C-C motif chemokine. (102 aa)
I3L9Z6_PIGUncharacterized protein. (335 aa)
PTPROProtein tyrosine phosphatase receptor type O. (1186 aa)
CCL5C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa)
CCL20C-C motif chemokine. (153 aa)
MSMPBeta-microseminoprotein. (156 aa)
CCL24SCY domain-containing protein. (183 aa)
CCL8C-C motif chemokine 8; Chemotactic factor that attracts monocytes. This protein can bind heparin. (99 aa)
LOC100516039C-C motif chemokine. (243 aa)
CCL21Putative CCL21 chemokine. (134 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (240 aa)
CCL14C-C motif chemokine. (99 aa)
CCL26C-C motif chemokine. (94 aa)
CCL16C-C motif chemokine. (120 aa)
CCL1C-C motif chemokine. (94 aa)
CCL19C-C motif chemokine. (100 aa)
CCL22C-C motif chemokine. (93 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (319 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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