STRINGSTRING
MUSK MUSK NTRK3 NTRK3 NRP1 NRP1 EGFR EGFR A0A5G2RBJ3_PIG A0A5G2RBJ3_PIG KIT KIT TWF1 TWF1 CSF1R CSF1R FLT1 FLT1 DSTYK DSTYK YES1 YES1 HCK HCK A0A287BQ46_PIG A0A287BQ46_PIG EPHB6 EPHB6 PTK2 PTK2 MELK MELK EPHA10 EPHA10 HMCN1 HMCN1 CLK4 CLK4 ABL1 ABL1 CLK3 CLK3 EPHA7 EPHA7 MATK MATK NRP2 NRP2 PDGFRA PDGFRA ABL2 ABL2 ROS1 ROS1 SLA2 SLA2 EFEMP1 EFEMP1 SRMS SRMS CLK2 CLK2 DYRK1A DYRK1A LCK LCK FGFR3 FGFR3 FGFRL1 FGFRL1 DCAF8 DCAF8 AXL AXL NTRK2 NTRK2 MERTK MERTK DYRK1B DYRK1B DYRK2 DYRK2 PTK6 PTK6 TYK2 TYK2 SYK SYK ITK ITK EPHA6 EPHA6 JAK1 JAK1 BAZ1B BAZ1B BLK BLK DDR1 DDR1 JAK3 JAK3 FGFR4 FGFR4 ZAP70 ZAP70 FGFR2 FGFR2 ALK ALK FGFR1 FGFR1 SRC SRC KDR KDR JAK2 JAK2 RIPK2 RIPK2 BMX BMX FLT3 FLT3 HIPK4 HIPK4 RPS6KA5 RPS6KA5 TNK1 TNK1 BTK BTK FER FER EPHA3 EPHA3 HIPK2 HIPK2 TNK2 TNK2 MST1R MST1R EPHB1 EPHB1 AATK AATK ERBB3 ERBB3 ERBB2 ERBB2 MAP2K6 MAP2K6 MET MET WEE2 WEE2 EPHA1 EPHA1 EPHA4 EPHA4 ERBB4 ERBB4 CLK1 CLK1 PDGFRB PDGFRB FLT4 FLT4 INSR INSR WEE1 WEE1 HIPK3 HIPK3 F1SPW0_PIG F1SPW0_PIG EPHB3 EPHB3 RET RET PTK2B PTK2B ROR2 ROR2 EPHA5 EPHA5 TEC TEC TXK TXK PKDCC PKDCC EPHB4 EPHB4 PDGFRL PDGFRL HIPK1 HIPK1 INSRR INSRR NTRK1 NTRK1 DDR2 DDR2 LYN LYN TEK TEK IGF1R IGF1R TYRO3 TYRO3 FRK FRK FYN FYN TIE1 TIE1 FGR FGR EPHB2 EPHB2 EPHA8 EPHA8 EPHA2 EPHA2 CSK CSK PEAK1 PEAK1 FES FES TTBK1 TTBK1 STYK1 STYK1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MUSKMuscle associated receptor tyrosine kinase. (869 aa)
NTRK3NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. (864 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (924 aa)
EGFRReceptor protein-tyrosine kinase. (1205 aa)
A0A5G2RBJ3_PIGTyrosine-protein kinase receptor. (542 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (975 aa)
TWF1Twinfilin actin binding protein 1. (366 aa)
CSF1RColony stimulating factor 1 receptor. (1053 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1302 aa)
DSTYKDual serine/threonine and tyrosine protein kinase. (1049 aa)
YES1Tyrosine-protein kinase. (553 aa)
HCKTyrosine-protein kinase. (527 aa)
A0A287BQ46_PIGUncharacterized protein. (229 aa)
EPHB6EPH receptor B6. (1006 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1119 aa)
MELKNon-specific serine/threonine protein kinase. (655 aa)
EPHA10EPH receptor A10. (1013 aa)
HMCN1Hemicentin-1. (5636 aa)
CLK4CDC like kinase 4; Belongs to the protein kinase superfamily. (481 aa)
ABL1Tyrosine-protein kinase. (1146 aa)
CLK3CDC like kinase 3; Belongs to the protein kinase superfamily. (495 aa)
EPHA7Ephrin type-A receptor 7 isoform 1. (998 aa)
MATKTyrosine-protein kinase. (485 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (920 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1088 aa)
ABL2Tyrosine-protein kinase. (1096 aa)
ROS1Tyrosine-protein kinase receptor. (2343 aa)
SLA2Uncharacterized protein. (561 aa)
EFEMP1EGF containing fibulin extracellular matrix protein 1. (512 aa)
SRMSTyrosine-protein kinase. (494 aa)
CLK2CDC like kinase 2. (529 aa)
DYRK1ADual specificity tyrosine phosphorylation regulated kinase 1A. (764 aa)
LCKTyrosine-protein kinase. (520 aa)
FGFR3Fibroblast growth factor receptor. (855 aa)
FGFRL1Fibroblast growth factor receptor like 1. (566 aa)
DCAF8DDB1 and CUL4 associated factor 8. (639 aa)
AXLUncharacterized protein. (871 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
MERTKMER proto-oncogene, tyrosine kinase. (998 aa)
DYRK1BDual specificity tyrosine phosphorylation regulated kinase 1B. (778 aa)
DYRK2Dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform 2. (601 aa)
PTK6Tyrosine-protein kinase. (449 aa)
TYK2Tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1226 aa)
SYK40 kDa tyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the recepto [...] (628 aa)
ITKTyrosine-protein kinase. (598 aa)
EPHA6EPH receptor A6. (1153 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
BAZ1BBromodomain adjacent to zinc finger domain 1B. (1483 aa)
BLKTyrosine-protein kinase. (501 aa)
DDR1Tyrosine-protein kinase receptor. (1005 aa)
JAK3Tyrosine-protein kinase. (1103 aa)
FGFR4Fibroblast growth factor receptor. (903 aa)
ZAP70Tyrosine-protein kinase. (615 aa)
FGFR2Fibroblast growth factor receptor. (820 aa)
ALKUncharacterized protein. (1034 aa)
FGFR1Fibroblast growth factor receptor. (820 aa)
SRCTyrosine-protein kinase. (559 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1360 aa)
JAK2Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] (1131 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (533 aa)
BMXTyrosine-protein kinase. (706 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (990 aa)
HIPK4Homeodomain-interacting protein kinase 4. (617 aa)
RPS6KA5Non-specific serine/threonine protein kinase. (957 aa)
TNK1Tyrosine kinase non receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (788 aa)
BTKTyrosine-protein kinase. (659 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
EPHA3Ephrin type-A receptor 3 isoform X1. (984 aa)
HIPK2Homeodomain interacting protein kinase 2. (1208 aa)
TNK2Tyrosine kinase non receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1159 aa)
MST1RMacrophage stimulating 1 receptor. (1398 aa)
EPHB1Ephrin type-B receptor 1. (984 aa)
AATKApoptosis associated tyrosine kinase. (1410 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1342 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (339 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1381 aa)
WEE2Wee1-like protein kinase 2; Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation. (565 aa)
EPHA1Ephrin type-A receptor 1. (982 aa)
EPHA4EPH receptor A4. (986 aa)
ERBB4Receptor protein-tyrosine kinase. (1201 aa)
CLK1CDC-like kinase 1; Belongs to the protein kinase superfamily. (484 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1181 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1362 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
WEE1Wee1-like protein kinase. (646 aa)
HIPK3Homeodomain-interacting protein kinase 3 isoform X1. (1216 aa)
F1SPW0_PIGWD_REPEATS_REGION domain-containing protein. (604 aa)
EPHB3Ephrin type-B receptor 3. (999 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1111 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (940 aa)
EPHA5EPH receptor A5. (1041 aa)
TECTyrosine-protein kinase. (632 aa)
TXKTyrosine-protein kinase. (551 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (493 aa)
EPHB4EPH receptor B4. (935 aa)
PDGFRLPlatelet-derived growth factor receptor-like protein. (375 aa)
HIPK1Homeodomain-interacting protein kinase 1 isoform 1. (1210 aa)
INSRRTyrosine-protein kinase receptor. (1315 aa)
NTRK1Tyrosine-protein kinase receptor. (795 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (866 aa)
LYNTyrosine-protein kinase. (512 aa)
TEKTEK receptor tyrosine kinase. (1147 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
TYRO3TYRO3 protein tyrosine kinase. (913 aa)
FRKTyrosine-protein kinase. (511 aa)
FYNTyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] (537 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
FGRTyrosine-protein kinase. (537 aa)
EPHB2EPH receptor B2. (987 aa)
EPHA8EPH receptor A8. (930 aa)
EPHA2Ephrin type-A receptor 2 isoform 1. (975 aa)
CSKTyrosine-protein kinase. (474 aa)
PEAK1Pseudopodium enriched atypical kinase 1. (1748 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
TTBK1Tau tubulin kinase 1. (1305 aa)
STYK1Serine/threonine/tyrosine kinase 1. (424 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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