STRINGSTRING
IL17RC IL17RC IL17RD IL17RD CCR1 CCR1 CXCR6 CXCR6 CNTFR CNTFR GFRA2 GFRA2 IL1R2 IL1R2 IL9R IL9R IL4R IL4R IL21R IL21R IL22RA2 IL22RA2 IL12RB2 IL12RB2 IL17REL IL17REL CSF2RB CSF2RB CCR5 CCR5 IL23R IL23R GFRA4 GFRA4 IL6R IL6R IL1R1 IL1R1 IFNAR1 IFNAR1 CCRL2 CCRL2 CSF3R CSF3R ACKR2 ACKR2 PRLR PRLR IL12RB1 IL12RB1 IFNLR1 IFNLR1 FZD4 FZD4 IL20RA IL20RA CCR10 CCR10 LOC110257900 LOC110257900 CXCR4 CXCR4 IL18R1 IL18R1 IL1RL1 IL1RL1 CSF2RA CSF2RA IFNGR2 IFNGR2 IL1RAP IL1RAP CD74 CD74 IL22RA1 IL22RA1 CRLF2 CRLF2 IL12B IL12B GHR GHR GPR75 GPR75 CRLF1 CRLF1 IL17RB IL17RB IL2RA IL2RA CCR9 CCR9 GFRAL GFRAL IL10RB IL10RB CCR4 CCR4 LOC110257903 LOC110257903 LOC102161330 LOC102161330 IFNAR2 IFNAR2 IL17RA IL17RA IL6ST IL6ST IL13RA2 IL13RA2 MPL MPL IL27RA IL27RA CXCR3 CXCR3 LIFR LIFR IFNGR1 IFNGR1 IL7R IL7R XCR1 XCR1 IL15RA IL15RA CCR2 CCR2 CCR8 CCR8 LEPR LEPR IL1RL2 IL1RL2 CCR6 CCR6 CX3CR1 CX3CR1 CD4 CD4 CCR7 CCR7 IL31RA IL31RA OSMR OSMR ACKR3 ACKR3 CXCR2 CXCR2 F1SS05_PIG F1SS05_PIG CXCR5 CXCR5 IL10RA IL10RA CDC25C CDC25C EPOR EPOR EBI3 EBI3 CD44 CD44 IL13RA1 IL13RA1 IL2RG IL2RG ACKR4 ACKR4 IL5RA IL5RA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL17RCIL17_R_N domain-containing protein. (511 aa)
IL17RDInterleukin-17 receptor D isoform a. (737 aa)
CCR1Chemokine (C-C motif) receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
CXCR6Chemokine (C-X-C motif) receptor 6; Belongs to the G-protein coupled receptor 1 family. (341 aa)
CNTFRCiliary neurotrophic factor receptor. (438 aa)
GFRA2GDNF family receptor alpha-2; Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. (464 aa)
IL1R2Interleukin 1 receptor type 2. (413 aa)
IL9RFibronectin type-III domain-containing protein. (290 aa)
IL4RInterleukin-4 receptor subunit alpha; Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 (By similarity). (830 aa)
IL21RInterleukin 21 receptor. (547 aa)
IL22RA2Interleukin 22 receptor subunit alpha 2. (231 aa)
IL12RB2Interleukin-12 receptor subunit beta-2; Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway; Belongs to the type I cytokine receptor family. Type 2 subfamily. (861 aa)
IL17RELIL17_R_N domain-containing protein. (452 aa)
CSF2RBColony stimulating factor 2 receptor beta common subunit. (893 aa)
CCR5C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family. (361 aa)
IL23RInterleukin 23 receptor. (631 aa)
GFRA4Uncharacterized protein. (367 aa)
IL6RInterleukin-6 receptor subunit alpha; Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis; Belongs to the type I cytokine receptor family. Type 3 subfamily. (491 aa)
IL1R1Interleukin-1 receptor type 1 isoform 1. (572 aa)
IFNAR1Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). (617 aa)
CCRL2Chemokine C-C motif receptor-like 2; Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine- triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptor. Plays a critical role for the development of Th2 responses (By similarity). (350 aa)
CSF3RGranulocyte colony-stimulating factor receptor. (848 aa)
ACKR2Atypical chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (385 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (624 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (749 aa)
IFNLR1Interferon lambda receptor 1. (519 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (536 aa)
IL20RAInterleukin 20 receptor subunit alpha. (689 aa)
CCR10G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (375 aa)
LOC110257900Cytokine receptor-like factor 2. (368 aa)
CXCR4C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (353 aa)
IL18R1Interleukin 18 receptor 1. (539 aa)
IL1RL1Interleukin 1 receptor like 1. (573 aa)
CSF2RAFibronectin type-III domain-containing protein. (446 aa)
IFNGR2Interferon gamma receptor 2 isoform 1. (369 aa)
IL1RAPInterleukin-1 receptor accessory protein isoform 3. (685 aa)
CD74Thyroglobulin type-1 domain-containing protein. (347 aa)
IL22RA1Interleukin 22 receptor subunit alpha 1. (660 aa)
CRLF2Cytokine receptor-like factor 2. (368 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (324 aa)
GHRGrowth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway. (660 aa)
GPR75Putative G-protein coupled receptor 75. (540 aa)
CRLF1Cytokine receptor like factor 1. (421 aa)
IL17RBInterleukin 17 receptor B. (477 aa)
IL2RAInterleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. (283 aa)
CCR9Chemokine (C-C motif) receptor 9 isoform A; Belongs to the G-protein coupled receptor 1 family. (369 aa)
GFRALGDNF family receptor alpha like. (457 aa)
IL10RBInterleukin-10 receptor subunit beta. (362 aa)
CCR4C-C chemokine receptor type 4 isoform X1; Belongs to the G-protein coupled receptor 1 family. (360 aa)
LOC110257903Fibronectin type-III domain-containing protein. (388 aa)
LOC102161330Fibronectin type-III domain-containing protein. (407 aa)
IFNAR2Uncharacterized protein. (574 aa)
IL17RAInterleukin 17 receptor A. (845 aa)
IL6STInterleukin 6 signal transducer. (938 aa)
IL13RA2Interleukin 13 receptor subunit alpha 2. (387 aa)
MPLMPL proto-oncogene, thrombopoietin receptor. (630 aa)
IL27RAUncharacterized protein. (683 aa)
CXCR3C-X-C chemokine receptor type 3 isoform 1; Belongs to the G-protein coupled receptor 1 family. (361 aa)
LIFRLIF receptor subunit alpha. (1170 aa)
IFNGR1Interferon gamma receptor 1. (470 aa)
IL7RFibronectin type-III domain-containing protein. (458 aa)
XCR1Chemokine XC receptor 1 isoform X1; Belongs to the G-protein coupled receptor 1 family. (333 aa)
IL15RASushi domain-containing protein. (305 aa)
CCR2C-C chemokine receptor type 2 isoform B; Belongs to the G-protein coupled receptor 1 family. (373 aa)
CCR8C-C motif chemokine receptor 8; Belongs to the G-protein coupled receptor 1 family. (379 aa)
LEPRLeptin receptor; Receptor for hormone LEP/leptin (By similarity). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductiv [...] (1165 aa)
IL1RL2Interleukin 1 receptor like 2. (644 aa)
CCR6C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (376 aa)
CX3CR1CX3C chemokine receptor 1 isoform a; Belongs to the G-protein coupled receptor 1 family. (356 aa)
CD4CD4 molecule. (494 aa)
CCR7G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (477 aa)
IL31RAInterleukin-31 receptor subunit alpha isoform 2. (717 aa)
OSMROncostatin-M-specific receptor subunit beta isoform X1. (977 aa)
ACKR3Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (362 aa)
CXCR2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (382 aa)
F1SS05_PIGG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (343 aa)
CXCR5C-X-C chemokine receptor type 5 isoform 1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
IL10RAInterleukin 10 receptor subunit alpha. (576 aa)
CDC25CM-phase inducer phosphatase 3; Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. Directly dephosphorylates CDK1 and activates its kinase activity. When phosphorylated, highly effective in activating G2 cells into prophase (By similarity). (501 aa)
EPORErythropoietin receptor; Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate LYN tyrosine kinase (By similarity). (509 aa)
EBI3Epstein-Barr virus induced 3. (228 aa)
CD44CD44 molecule (Indian blood group). (767 aa)
IL13RA1Uncharacterized protein. (421 aa)
IL2RGCytokine receptor common subunit gamma. (395 aa)
ACKR4Chemokine (C-C motif) receptor-like protein 1; Belongs to the G-protein coupled receptor 1 family. (350 aa)
IL5RAInterleukin 5 receptor subunit alpha. (420 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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